Development of a fast proton range radiography system for quality assurance in hadrontherapy

Bucciantonio, M.; Amaldi, U.; Kieffer, R.; Sauli, F.; Watts, D.

doi:10.1016/j.nima.2013.05.110

Cited by 28 publications

(26 citation statements)

References 9 publications

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“…The most extensively investigated single particle tracking configuration relies on fast performing position sensitive detectors, e.g., scintillating fiber hodoscopes 8,14 , gas-based electron multiplying detectors such as GEM (Gas-Electron-Multiplier) 17 or micromegas 18 , or silicon strip detectors 7,18 , placed before and after the imaging object. The tracking system is synchronized with the residual energy or range measurement in a single calorimeter 8 or a stack of detectors, such as plastic scintillators 14,17,19 (figure 1a) or even solid state detectors 20 . This way, a so called list mode of events is created, containing the individual ion entrance and exit positions (and possibly directions, depending on the number of tracking planes) with associated residual energy/range after the traversed object.…”

Section: General Purpose Techniquesmentioning

confidence: 99%

In vivo range verification in particle therapy

2018

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Exploitation of the full potential offered by ion beams in clinical practice is still hampered by several sources of treatment uncertainties, particularly related to limitations of our ability to locate the position of the Bragg peak in the tumour. To this end, several efforts are ongoing to improve the characterization of patient position, anatomy and tissue stopping power properties prior to treatment, as well as to enable in-vivo verification of the actual dose delivery, or at least beam range, during or shortly after treatment. This contribution critically reviews methods under development or clinical testing for verification of ion therapy, based on pre-treatment range and tissue probing as well as detection of secondary emissions or physiological changes during and after treatment, trying to disentangle approaches of general applicability from those more specific to certain anatomical locations. Moreover, it discusses future directions, which could benefit from integration of multiple modalities or address novel exploitation of the measurable signals for biologically adapted therapy.

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Section: General Purpose Techniquesmentioning

confidence: 99%

In vivo range verification in particle therapy

2018

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“…An energy-specific calibration curve was constructed for the imaging system to calculate the WET of any phantom being imaged. The calibration curve was plotted by stacking 8 plastic water slabs of known physical thicknesses (5,10,20,40,60,80, 100, and 110 mm) in front of the scintillator volume. The slabs were positioned in the x-y plane (see figure 1) such that their thicknesses were along the z-axis.…”

Section: Calibration Curvementioning

confidence: 99%

A proton imaging system using a volumetric liquid scintillator: a preliminary study

Darne

Alsanea

Robertson

et al. 2019

Biomed. Phys. Eng. Express

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With the expansion of proton radiotherapy for cancer treatments, it has become important to explore proton-based imaging technologies to increase the accuracy of proton treatment planning, alignment, and verification. The purpose of this study is to demonstrate the feasibility of using a volumetric liquid scintillator to generate proton radiographs at a clinically relevant energy (180 MeV) using an integrating detector approach. The volumetric scintillator detector is capable of capturing a wide distribution of residual proton beam energies from a single beam irradiation. It has the potential to reduce acquisition time and imaging dose compared to other proton radiography methods. The imaging system design is comprised of a volumetric (20 × 20 × 20 cm 3 ) organic liquid scintillator working as a residual-range detector and a charge-coupled device (CCD) placed along the beams'-eye-view for capturing radiographic projections. The scintillation light produced within the scintillator volume in response to a 3-dimensional distribution of residual proton beam energies is captured by the CCD as a 2-dimensional grayscale image. A light intensity-to-water equivalent thickness (WET) curve provided WET values based on measured light intensities. The imaging properties of the system, including its contrast, signal-to-noise ratio, and spatial resolution (0.19 line-pairs/mm) were determined. WET values for selected Gammex phantom inserts including solid water, acrylic, and cortical bone were calculated from the radiographs with a relative accuracy of −0.82%, 0.91%, and −2.43%, respectively. Image blurring introduced by system optics was accounted for, resulting in sharper image features. Finally, the system's ability to reconstruct proton CT images from radiographic projections was demonstrated

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“… 56 Proton range radiography was one of the stated objectives and this led to the construction of their PRR30 system. 57 – 59 The full-scale system was demonstrated using X-ray beams in 2013. The primary goal of the project was radiography rather than tomography and we are not aware of any use of the PRR30 as a CT acquisition system.…”

Section: The Modern Eramentioning

confidence: 99%

“… 33 , 69 These numbers were calculated based on elemental radiation lengths 78 and typical compositions. It has been suggested that GEM detectors typically have a thickness of 1% of radiation length, 59 which gives comparable scatter.…”

Section: General Design Considerationsmentioning

confidence: 99%

Proton radiography and tomography with application to proton therapy

Poludniowski¹,

Allinson²,

Evans³

2015

BJR

149

163

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Proton radiography and tomography have long promised benefit for proton therapy. Their first suggestion was in the early 1960s and the first published proton radiographs and CT images appeared in the late 1960s and 1970s, respectively. More than just providing anatomical images, proton transmission imaging provides the potential for the more accurate estimation of stopping-power ratio inside a patient and hence improved treatment planning and verification. With the recent explosion in growth of clinical proton therapy facilities, the time is perhaps ripe for the imaging modality to come to the fore. Yet many technical challenges remain to be solved before proton CT scanners become commonplace in the clinic. Research and development in this field is currently more active than at any time with several prototype designs emerging. This review introduces the principles of proton radiography and tomography, their historical developments, the raft of modern prototype systems and the primary design issues.

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Development of a fast proton range radiography system for quality assurance in hadrontherapy

Cited by 28 publications

References 9 publications

In vivo range verification in particle therapy

In vivo range verification in particle therapy

A proton imaging system using a volumetric liquid scintillator: a preliminary study

Proton radiography and tomography with application to proton therapy

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