Development of a FPW allergy biosensor for human IgE detection by MEMS and cystamine-based SAM technologies

Huang, I‐Yu; Lee, M.-C.

doi:10.1016/j.snb.2008.01.048

Cited by 75 publications

(59 citation statements)

References 21 publications

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“…Compared to our previous research, 18 as shown in Table 4, the proposed FPW device has demonstrated a lower insertion loss (−40.854 dB), lower operating frequency (6.388 MHz), and higher quality factor (206) than conventional FPW devices with Si-based thin plate and without RGS design. Calculated by Eq.…”

Section: Characterization Of the Proposed Fpw-afp Biosensormentioning

confidence: 69%

“…Conventional FPW devices are constructed by Si 3 N 4 ∕Si∕Au∕ZnO multilayer and their phase velocities are about 900 to 1000 m∕s. 18 To reduce the phase velocity and operating frequency of FPW, this work replaces the silicon thin plate material by silicon dioxide. The finite element model of the proposed thin floating plates is shown in Fig.…”

Section: Propagation Properties Modeling Of Fpwmentioning

confidence: 99%

“…Combined with the essential specificity of antigen-antibody reactions, some of these immunosensors have gained attention as methods for clinical diagnosis. [7][8][9][10][11][12][13][14][15][16][17][18][19] In general, the performance of an immunosensor is measured by its capability to detect molecular layers deposited on a surface. For instance, the loading mass on the sensing surface of conventional acoustic sensors can affect some propagating properties of the acoustic wave.…”

Section: Introductionmentioning

confidence: 99%

“…Any small changes in the mass of floating thin plate of the FPW transducer resulting in a change of the acoustic wave velocity can be measured indirectly as a change in center frequency of the FPW-based biosensor. [9][10][11][12][13][14][15][16][17][18][19] However, the high insertion loss and low quality factor of conventional FPW-based biosensors have limited their applications. To enhance the quality factor and reduce the insertion loss and phase velocity of a FPW-based biosensor, this paper introduces a novel groove-type reflective grating structure (RGS) and adopts a low phase velocity insulator membrane (5-μm-thick SiO 2 ) to replace the conventional silicon-based membrane.…”

Section: Introductionmentioning

confidence: 99%

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Improvement of insertion loss and quality factor of flexural plate-wave-based alpha-fetoprotein biosensor using groove-type reflective grating structures

Lin

Huang

Lan

2013

J. Micro/Nanolith. MEMS MOEMS

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Abstract. Conventional flexural plate-wave (FPW) transducers have limited applications in biomedical sensing due to their disadvantages such as high insertion loss and low quality factor. To overcome these shortcomings, we propose a FPW transducer on a low phase velocity insulator membrane (5-μm-thick SiO 2 ) with a novel groove-type reflective grating structure design. Additionally, a cystamine self-assembly monolayer and a glutaraldehyde cross-linking layer are implemented on the backside of the FPW device to immobilize alpha-fetoprotein (AFP) antibody. A FPWbased AFP biosensor with low detection limit (5 ng∕mL) can be achieved and used to measure the extreme low concentration of AFP antigen in human serum for early detection of hepatocellular carcinoma. The proposed FPW-based AFP biosensor also demonstrates a very high quality factor (206), low insertion loss (−40.854 dB), low operating frequency (6.388 MHz), and high sensing linearity (90.7%). © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Section: Characterization Of the Proposed Fpw-afp Biosensormentioning

confidence: 69%

Section: Propagation Properties Modeling Of Fpwmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Improvement of insertion loss and quality factor of flexural plate-wave-based alpha-fetoprotein biosensor using groove-type reflective grating structures

Lin

Huang

Lan

2013

J. Micro/Nanolith. MEMS MOEMS

View full text Add to dashboard Cite

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“…7 cm 2 /g at a wave frequency of 9MHz was reported for the ZnO based Lamb wave sensor during detection human IgE based on conventional cystamine SAM technology (133).…”

Section: Recent Achievements In Zno Nanocrystal Based Biosensorsmentioning

confidence: 99%