Development of a gas chromatography method for the determination of isotretinoin and its degradation products in pharmaceuticals

Lima, Eliana Martins; Diniz, Danielle Guimarães Almeida; Filho, Nelson Roberto Antoniosi

doi:10.1016/j.jpba.2005.02.015

Cited by 17 publications

(7 citation statements)

References 28 publications

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“…Para tanto, foi preparada uma solução de 50 µg/ml de tretinoína em balão volumétrico âmbar de 10 ml com metanol. (LIMA et al, 2005). Muitos autores utilizam a análise cromatográfica por CLAE para determinação da isotretinoína e seus metabólitos, sendo mais comum a separação em fase reversa (tabela 3).…”

Section: Perfil Cromatográfico Da Tretinoína (Principal Isômero)unclassified

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Biopharmaceutics of 13-cis-retinoic acid (isotretinoin) formulated with modified β-cyclodextrins

Lin¹,

Leong²,

Yang³

et al. 2007

International Journal of Pharmaceutics

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13-cis-Retinoic acid (13-cis-RA), also known as isotretinoin, is commonly used in the management of severe acne. Its clinical efficacy in oncology has also been documented. As a vitamin A derivative, it is not soluble in water. This solubility barrier not only affects its oral absorption but also makes parenteral delivery difficult. Recently, water-soluble formulations of 13-cis-RA have been attempted with 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) and randomly methylated-beta-cyclodextrin (RM-beta-CD). In this study, the pharmacokinetic profiles of these two formulations were assessed in Sprague-Dawley rats after single intravenous or oral administration. We found that 13-cis-RA was eliminated from the body through a dose-independent process after intravenous injection of either sodium salt or the HP-beta-CD formulation within the tested dosage range (2.0-7.5mg/kg). Furthermore, HP-beta-CD did not alter the kinetic profile of 13-cis-RA after intravenous administration in comparison with 13-cis-RA sodium salt. We also found that RM-beta-CD dramatically enhanced the oral absorption of 13-cis-RA. At 10.0mg/kg, the bioavailability of 13-cis-RA formulated with RM-beta-CD was about three-fold higher than that of the control (13-cis-RA suspended in 0.5% carboxymethylcellulose (CMC)). Similarly, the oral absorption of 13-cis-RA was not saturated within our tested range (2.5-10.0mg/kg) and the bioavailability remained unchanged. These results demonstrated that HP-beta-CD and RM-beta-CD were suitable excipients for the delivery of 13-cis-RA.

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Section: Perfil Cromatográfico Da Tretinoína (Principal Isômero)unclassified

“…Tabela 3 -Exemplos de métodos cromatográficos para quantificação da isotretinoína por CLAE (LIMA et al, 2005. ).…”

Section: Perfil Cromatográfico Da Tretinoína (Principal Isômero)unclassified

Biopharmaceutics of 13-cis-retinoic acid (isotretinoin) formulated with modified β-cyclodextrins

Lin¹,

Leong²,

Yang³

et al. 2007

International Journal of Pharmaceutics

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“…18,19 Various voltammetry methods: cyclic, differential pulse, and square wave are the most widely used, many reports attest to their importance in detection of pharmaceutical compounds. Other sophisticated methods which are quantitative and qualitative for HIV drugs in biological samples such as chromatography 20 (HPLC, TLC, and GC) immunoassays, photometric (nuclear magnetic resonance and ultraviolet-visible) 21 have been reported in literature.…”

Section: Anti-hiv Drugsmentioning

confidence: 99%

Review—Nanostructured Electrochemical Sensors for Determination of the First Generation of the NNRTIs for HIV-1

Silwana

Matoetoe²

2022

ECS Adv.

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Since the 1980s, the HIV/AIDS pandemic has been a global concern and remains despite the tremendous efforts and successes in the development of antiviral drugs. The drug development and formulation process are not without challenges. However, the effective use of excipients can allow formulators to circumvent or at least minimize the impact of these challenges. Some of the challenges include ensuring a high quality of actives, free from impurities, and ensuring administration in appropriate quantities. Incorrect dosing can have a detrimental impact on the body. Evaluation of the quality and physiological function of these drugs in pharmaceutical and biological samples is vital. We explore the application of electrochemical methods for the detection of these drugs. Electrochemical methods are versatile and cheaper in comparison to conventional techniques. This review paper provides the latest developments and new trends in electroanalysis of the first generation of nonnucleoside reverse transcriptase inhibitors drugs. Furthermore, we highlight several phenomena occurring on bare solid electrodes and modified electrodes, including underlying mechanisms. Recent data shows that modified electrodes based on nanoparticles present substantial advantages over their non-modified counterparts enabling portability, higher selectivity, and multiple detection capabilities. These characteristics make nanoparticles promising candidates for the design of sensors.

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“…1. For determination of retinoids in dermatological formulations, there are few UV-Visible spectroscopic methods reported [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17], but there are several other methods have been reported for the determination like chromatography [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34]12]. However, most of these methods are complicated and not available at most laboratories.…”

Section: Introductionmentioning

confidence: 99%

Spectrophotometric Micro Determination of Tretinoin, Isotretinoin using Iodine and Tazarotene micro determination via Reaction with Rose-Bengal Reagent

Zayed

Basset

2017

Egypt. J. Chem.

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Development of a gas chromatography method for the determination of isotretinoin and its degradation products in pharmaceuticals

Cited by 17 publications

References 28 publications

Biopharmaceutics of 13-cis-retinoic acid (isotretinoin) formulated with modified β-cyclodextrins

Biopharmaceutics of 13-cis-retinoic acid (isotretinoin) formulated with modified β-cyclodextrins

Review—Nanostructured Electrochemical Sensors for Determination of the First Generation of the NNRTIs for HIV-1

Spectrophotometric Micro Determination of Tretinoin, Isotretinoin using Iodine and Tazarotene micro determination via Reaction with Rose-Bengal Reagent

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