Development of a Graphene-Based Surface Plasmon Resonance Optical Sensor Chip for Potential Biomedical Application

Abstract

The emergence of unintentional poisoning and uncontrolled vector diseases have contributed to sensor technologies development, leading to the more effective detection of diseases. In this study, we present the combination of graphene-based material with surface plasmon resonance technique. Two different graphene-based material sensor chips were prepared for rapid and quantitative detection of dengue virus (DENV) and cobalt ion (Co2+) as an example of typical metal ions. As the fundamental concept of surface plasmon resonance (SPR) sensor that relies on the refractive index of the sensor chip surface, this research focused on the SPR signal when the DENV and Co2+ interact with the graphene-based material sensor chip. The results demonstrated that the proposed sensor-based graphene layer was able to detect DENV and Co2+ as low as 0.1 pM and 0.1 ppm respectively. Further details in the detection and quantification of analyte were also discussed in terms of sensitivity, affinity, and selectivity of the sensor.

Recent Advances in Electrochemical and Optical Sensing of Dopamine

“…As powerful analytical tools that have enjoyed widespread attention over the past two decades, SPR sensors have been developed in several configurations to detect several analytes. These sensors serve in different fields such as medical diagnostics [318][319][320][321][322], food quality [323,324], environmental protection [325][326][327][328][329][330][331] and others. SPR, a refractive index-based detection technique has emerged as a promising sensing platform for sensitive detection of NTs, especially DA due to its substantial advantages.…”

Nanostructured Chitosan/Maghemite Composites Thin Film for Potential Optical Detection of Mercury Ion by Surface Plasmon Resonance Investigation

“…Since enormous efforts devoted to creating sensors with high sensitivity to Hg 2+ are greatly needed currently, selection of the metallic layer such as the gold layer is an important aid in producing higher sensor sensitivity in SPR [41]. Over the last decade, the surface SPR technique has emerged as an effective optical technique for various applications including detection of heavy metal ions [42][43][44][45][46][47][48][49][50][51]. Unfortunately, the main problem to detect optically the heavy metal ions solution is the similar refractive indices of heavy metal ions for lowest concentration, which eventually becomes the goal of researchers.…”

Lab-on-a-Chip Systems for Aptamer-Based Biosensing

“…Surface plasmon resonance (SPR)-based sensing has received increased popularity not only in gas sensing, but also in many other applications including in medical diagnostics, food safety, and biology [105] due to its advantages that enable label-free detection, real-time detection, high sensitivity as well as its ease of preparation [106]. SPR is an optical technique that relies on the change in the refractive index of a metal surface on which the target molecules are immobilized.…”

“…In addition, graphene enables efficient adsorption of biomolecules on its surface due to its high surface-to-volume ratio and the π-π stacking interactions with the biomolecules. Furthermore, an external gate voltage can be used to modulate the frequency of the surface plasmonics in the infrared spectrum easily [106]. Wei et al proposed a cavity-enhanced infrared sensor based on graphene surface plasmonics [119], wherein a continuous and non-patterned graphene that excites the surface plasmon on its surface was used as the sensing medium.…”