Development of a green synthesized silver nanoparticle-based antioxidant capacity method using carob extract

Beğiç, Nilay; Bener, Mustafa; Apak, Reşat

doi:10.1007/s40097-020-00374-6

Cited by 13 publications

(5 citation statements)

References 47 publications

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“…To eliminate interference from trace amounts of Yb‐DOBDC in the supernatant, a relationship was established between the characteristic UV absorption peaks of Yb‐DOBDC and the absorbance at 200 nm (Figure S15, Supporting Information), based on the additivity of absorbance at low concentrations. [ 17 ] The accuracy and reliability of this method were confirmed through repeated experiments (Figure S16, Supporting Information).The adsorption kinetics of L‐Arg on Yb‐DOBDC were investigated at a concentration of 0.9 mM. As indicated in Figure S17 (Supporting Information), the adsorption process was characterized by a rapid uptake in the initial phase, where the adsorption rate reached 94% within 25 min, demonstrating a high affinity between L‐Arg and the active sites of Yb‐DOBDC.…”

Section: Resultsmentioning

confidence: 99%

High‐Loading L‐Arginine Stabilized in an Oxygen‐Rich Lanthanide Metal–Organic Framework Capable of NO Release and Self‐Quantifying Luminescence Detection

Xu,

Wang,

et al. 2024

Advanced Optical Materials

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Exogenous supplementation of L‐arginine (L‐Arg) facilitates the release of nitric oxide (NO) for gas therapy applications in tumor microenvironments rich in H2O2. However, direct administration inevitably leads to the premature release of hydrophilic L‐Arg in the bloodstream, potentially resulting in unstable plasma L‐Arg concentrations and subsequent adverse reactions. Therefore, it is crucial to identify efficient and stable high‐dose L‐Arg delivery carriers, albeit challenging. Here, the study has achieved high (≈94 mg g−1) and stable L‐Arg loading within a 12‐coordinated Yb‐based lanthanide metal‐organic framework (named Yb‐DOBDC, where DOBDC is 2,5‐dihydroxyterephthalic acid). Yb‐DOBDC features size‐matched apertures and oxygen‐rich pore microenvironments, securely entrapping L‐Arg through electrostatic interactions and conjugation effects, thereby enhancing the biostability of the drug during delivery. In vitro experiments demonstrate that L‐Arg‐loaded Yb‐DOBDC (L‐Arg@Yb‐DOBDC) promotes NO release upon H2O2 stimulation, and the Yb‐DOBDC framework exhibits good biocompatibility within cells. More interestingly, the near‐infrared‐luminescence‐emitting Yb‐DOBDC exhibits a “turn‐off” behavior upon gradual loading of L‐Arg, enabling self‐quantifying luminescence detection during the encapsulation process. Consequently, the L‐Arg@Yb‐DOBDC system designed in this work, with its high/stable loading capacity and self‐quantifying luminescence detection capability, holds theoretical research value and potential practical application prospects.

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Section: Resultsmentioning

confidence: 99%

High‐Loading L‐Arginine Stabilized in an Oxygen‐Rich Lanthanide Metal–Organic Framework Capable of NO Release and Self‐Quantifying Luminescence Detection

Xu,

Wang,

et al. 2024

Advanced Optical Materials

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“…Usually, the best results were obtained with basic pH. 1,[46][47][48] AgNPs synthesis reaction performed at acidic pH (ranging from 2 to 5) resulted in immediate precipitation of the reaction mixture thus failing to formed AgNPs. The yield of the reaction improved at pH 6; however, NPs aggregation occurred within 4 days as conrmed by electron microscopy (Fig.…”

Section: Synthesis Of Agnps From S Asoca Aqueous Leaf Extractmentioning

confidence: 99%

Effect of the physicochemical changes in the antimicrobial durability of green synthesized silver nanoparticles during their long-term storage

et al. 2022

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“…21,22 Among various scaffold materials, apatite-based nanomaterials are considered an ideal drug delivery system for the regenerative therapy of periodontal tissue due to their chemical and biomechanical similarity to the mineral phase of natural bone tissue. [23][24][25][26] However, traditional drug-loading approaches such as physical adsorption and chemical bonding cannot endow apatite nanomaterials with the capacity to release therapeutic cargo in response to external stimuli. 27 Moreover, synthetic apatite nanocrystals with irregular size, morphology, and crystallinity are susceptible to induce a foreign body reaction characterized by local chronic inflammation, imposing a negative impact on tissue repair.…”

Section: Introductionmentioning

confidence: 99%

A Biomimetic Smart Nanoplatform as “Inflammation Scavenger” for Regenerative Therapy of Periodontal Tissue

Chen¹,

Zhang²,

He³

et al. 2022

IJN

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The functional reconstruction of periodontal tissue defects remains a clinical challenge due to excessive and prolonged host response to various endogenous and exogenous pro-inflammatory stimuli. Thus, a biomimetic nanoplatform with the capability of modulating inflammatory response in a microenvironment-responsive manner is attractive for regenerative therapy of periodontal tissue. Methods: Herein, a facile and green design of engineered bone graft materials was developed by integrating a biomimetic apatite nanocomposite with a smart-release coating, which could realize inflammatory modulation by "on-demand" delivery of the antiinflammatory agent through a pH-sensing mechanism. Results: In vitro and in vivo experiments demonstrated that this biocompatible nanoplatform could facilitate the clearance of reactive oxygen species in human periodontal ligament stem cells under inflammatory conditions via inhibiting the production of endogenous proinflammatory mediators, in turn contributing to the enhanced healing efficacy of periodontal tissue. Moreover, this system exhibited effective antimicrobial activity against common pathogenic bacteria in the oral cavity, which is beneficial for the elimination of exogenous pro-inflammatory factors from bacterial infection during healing of periodontal tissue. Conclusion:The proposed strategy provides a versatile apatite nanocomposite as a promising "inflammation scavenger" and propels the development of intelligent bone graft materials for periodontal and orthopedic applications.

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Development of a green synthesized silver nanoparticle-based antioxidant capacity method using carob extract

Cited by 13 publications

References 47 publications

High‐Loading L‐Arginine Stabilized in an Oxygen‐Rich Lanthanide Metal–Organic Framework Capable of NO Release and Self‐Quantifying Luminescence Detection

High‐Loading L‐Arginine Stabilized in an Oxygen‐Rich Lanthanide Metal–Organic Framework Capable of NO Release and Self‐Quantifying Luminescence Detection

Effect of the physicochemical changes in the antimicrobial durability of green synthesized silver nanoparticles during their long-term storage

A Biomimetic Smart Nanoplatform as “Inflammation Scavenger” for Regenerative Therapy of Periodontal Tissue

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