Development of a high quantum yield dye for tumour imaging

Abstract

An easily accessible fluorescent dye, FEB, which has a high fluorescence quantum yield and is suitable for in vivo tumour imaging is reported.

Comparative study of one-step and two-step quantitative fluorescence photoacoustic tomography

“…(3) becomes significant and, neglecting that, in the reconstructions yields erroneous results. We note that, of late, fluorescent markers having high quantum efficiencies while having low toxicity are reported to be under development [5].…”

“…Fluorescent markers have been widely employed to enhance the PA signals and hence assist in deep photoacoustic (PA) imaging [3,4]. Fluorescent markers having high quantum efficiencies while having low toxicity are reported to be under development [5]. Major progress has been made in diseasespecific fluorescent markers, experimental setups, and reconstruction algorithms of FOT [6,7].…”

Recent advances in near-infrared II fluorophores for multifunctional biomedical imaging

“… 81 , 82 In order to enhance the QY, Dai and Liang's group introduced a shielding unit (S) to the D–A–D scaffold and the side chains of the shielding units extend out of the conjugated backbone, excluding the continuous intermolecular interactions. 82 – 85 Moreover, the utilization of a 3,4-ethylenedioxy thiophene (EDOT) donor, replacing thiophene, could manifestly increase the quantum yield. 82 , 83 Thus, several optimized NIR-II organic fluorophores based on the S–D–A–D–S scaffold with improved fluorescent characteristics have been established and the elevated fluorescence brightness facilitated multifunctional NIR-II bioimaging, such as dynamic vascular changes in a traumatic brain injury mouse model and multicolor molecular 3D imaging of histological brain tissues.…”

Novel dual-function near-infrared II fluorescence and PET probe for tumor delineation and image-guided surgery

“…NIR-II probes possess high spatial resolution and deep-tissue penetration due to reduced photon scattering and diminished auto-fluorescence. 8 – 13 At present, several classes of fluorescent NIR-II probes including small molecules, 14 – 17 carbon nanotubes, 18 , 19 Ag 2 S dots 20 , 21 and polymers 22 have been actively employed for NIR-II fluorescence for superior vascular imaging, cerebral imaging, lymphatic imaging and imaging-guided surgery. 23 , 24 …”