Novel dual-function near-infrared II fluorescence and PET probe for tumor delineation and image-guided surgery

Sun, Yao; Zeng, Xiaodong; Xiao, Yuling; Liu, Changhao; Zhu, Hua; Zhou, Hui; Chen, Ziyang; Xu, Fuchun; Wang, Jule; Zhu, Mengyue; Wu, Junzhu; Tian, Mei; Zhang, Hong; Deng, Zixin; Cheng, Zhen; Hong, Xuechuan

doi:10.1039/c7sc04774f

Cited by 154 publications

(107 citation statements)

References 43 publications

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“…[31,33,42,81,[123][124][125][126] Besides the abovementioned CH1055-PEG and CH-4T, [35,81] this team reported a series of other CH1055 derivative materials, including CQS1000, H1, silk xanthan hydrogel (SXH), and succinate dehydrogenase (SDH) NPs ( Figure 5). [31,33,42,81,[123][124][125][126] Besides the abovementioned CH1055-PEG and CH-4T, [35,81] this team reported a series of other CH1055 derivative materials, including CQS1000, H1, silk xanthan hydrogel (SXH), and succinate dehydrogenase (SDH) NPs ( Figure 5).…”

Section: Fluorescence Imagingmentioning

confidence: 99%

“…They also tested PET-SERRS NPs via intravenous administration for liver cancer delineation with indirect imaging (distinct filling defects signals in liver representing tumors), due to its high accumulation in normal RES tissue with significantly low uptake in cancer. [42] Cerenkov luminescence (CL), an emerging optical imaging technique, is the visualization of Cerenkov radiation that can be acquired from PET radiotracers. Cheng's team reported an α v β 3 integrin-targeted PET/NIR II nanoprobe ( 68 Ga-SCH2) for tumor delineation and targeting IGS.…”

Section: Pet/spect/ct-based Multimodal Imagingmentioning

confidence: 99%

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Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

et al. 2019

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Surgical resection is the primary and most effective treatment for most patients with solid tumors. However, patients suffer from postoperative recurrence and metastasis. In the past years, emerging nanotechnology has led the way to minimally invasive, precision and intelligent oncological surgery after the rapid development of minimally invasive surgical technology. Advanced nanotechnology in the construction of nanomaterials (NMs) for precision imaging-guided surgery (IGS) as well as surgery-assisted synergistic therapy is summarized, thereby unlocking the advantages of nanotechnology in multimodal IGS-assisted precision synergistic cancer therapy. First, mechanisms and principles of NMs to surgical targets are briefly introduced. Multimodal imaging based on molecular imaging technologies provides a practical method to achieve intraoperative visualization with high resolution and deep tissue penetration. Moreover, multifunctional NMs synergize surgery with adjuvant therapy (e.g., chemotherapy, immunotherapy, phototherapy) to eliminate residual lesions. Finally, key issues in the development of ideal theranostic NMs associated with surgical applications and challenges of clinical transformation are discussed to push forward further development of NMs for multimodal IGS-assisted precision synergistic cancer therapy.

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Section: Fluorescence Imagingmentioning

confidence: 99%

Section: Pet/spect/ct-based Multimodal Imagingmentioning

confidence: 99%

Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

et al. 2019

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“…Anti-EGFR Affibody [30] ICG 782/880-1450 0.9 Imaging of vasculature and imaging-guided PDT Non-specific, RGD [54,64] 68 Ga-CHS2 808/1050 0.2 Image-guided tumor surgery RGD [65] SXH, SDH, and H1 NPs 808/1100 2.0 Tumor vessel imaging and image-guided SLN surgery RGD peptide [66] CQS1000 NPs 808/1000 -Imaging of tumor angiogenesis and Image-guided tumor surgery and SLN biopsy…”

Section: Conclusion and Perspectivementioning

confidence: 99%

Advanced NIR‐II Fluorescence Imaging Technology for In Vivo Precision Tumor Theranostics

Wang

2019

Advanced Therapeutics

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As a cutting-edge imaging technology, fluorescence imaging in the second near-infrared (NIR-II, 1000-1700 nm) window has attracted tremendous attention. Compared to the classical fluorescence imaging in the visible (400-650 nm) and NIR-I (650-950 nm) window, the NIR-II fluorescence imaging greatly improves photon penetration in living bodies with high fidelity due to its minimized tissue absorption, scattering, and autofluorescence. It is considered to be the next-generation intravital fluorescence imaging technique which has great potential for biomedical research and clinical practice. Herein, the progress of NIR-II fluorescence imaging in tumor theranostics is summarized. The recent advances in tumor diagnosis and therapeutic evaluation using this novel imaging technique are highlighted, and its current challenges and future perspectives are discussed.Fluorescence imaging technology opens a new era of biomedical research, which provides a straightforward visible approach

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“…By contrast, positron emission tomography (PET) with virtually unlimited tissue penetrating depth, high sensitivity, and quantitative effect can eliminate the above defects of NIR‐II imaging in tumor diagnosis and therapy . However, PET suffers from its own drawbacks such as low spatial revolution, time consuming process, and difficulty for application in intraoperative guidance . These drawbacks of PET seem likely to be overcome by NIR‐II imaging.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, our group has made successful attempts in the development of PET and NIR‐II dual modal probe based on a small‐molecule platform . Specifically, a small‐molecule NIR‐II dye (CH1055) has been conjugated with a radiolabeling chelator (1,4,7‐triazacyclononane‐1,4,7‐triacetic acid, NOTA) and a α v β 3 receptor targeting peptide (RGD) via base‐catalyzed thiol addition chemistry.…”

Section: Introductionmentioning

confidence: 99%

Hierarchically Nanostructured Hybrid Platform for Tumor Delineation and Image‐Guided Surgery via NIR‐II Fluorescence and PET Bimodal Imaging

Zhang

Zhou

Chen

et al. 2019

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Bimodal imaging with fluorescence in the second near infrared window (NIR‐II) and positron emission tomography (PET) has important significance for tumor diagnosis and management because of complementary advantages. It remains challenging to develop NIR‐II/PET bimodal probes with high fluorescent brightness. Herein, bioinspired nanomaterials (melanin dot, mesoporous silica nanoparticle, and supported lipid bilayer), NIR‐II dye CH‐4T, and PET radionuclide 64Cu are integrated into a hybrid NIR‐II/PET bimodal nanoprobe. The resultant nanoprobe exhibits attractive properties such as highly uniform tunable size, effective payload encapsulation, high stability, dispersibility, and biocompatibility. Interestingly, the incorporation of CH‐4T into the nanoparticle leads to 4.27‐fold fluorescence enhancement, resulting in brighter NIR‐II imaging for phantoms in vitro and in situ. Benefiting from the fluorescence enhancement, NIR‐II imaging with the nanoprobe is carried out to precisely delineate and resect tumors. Additionally, the nanoprobe is successfully applied in tumor PET imaging, showing the accumulation of the nanoprobe in a tumor with a clear contrast from 2 to 24 h postinjection. Overall, this hierarchically nanostructured platform is able to dramatically enhance fluorescent brightness of NIR‐II dye, detect tumors with NIR‐II/PET imaging, and guide intraoperative resection. The NIR‐II/PET bimodal nanoprobe has high potential for sensitive preoperative tumor diagnosis and precise intraoperative image‐guided surgery.

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Novel dual-function near-infrared II fluorescence and PET probe for tumor delineation and image-guided surgery

Abstract: The first small-molecule based αvβ3-targeted NIR-II/PET dual-modal probes via base-catalyzed thiol-addition chemistry were concisely assembled and evaluated.

Cited by 154 publications

References 43 publications

Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

Advanced NIR‐II Fluorescence Imaging Technology for In Vivo Precision Tumor Theranostics

Hierarchically Nanostructured Hybrid Platform for Tumor Delineation and Image‐Guided Surgery via NIR‐II Fluorescence and PET Bimodal Imaging

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