Development of a high resolution three-dimensional surgical atlas of the murine head for strains 129S1/SvImJ and C57Bl/6J using magnetic resonance imaging and micro-computed tomography

Chan, Elisa K.; Kovacevic, Natasha; Ho, S.K.Y.; Henkelman, R. Mark; Henderson, Jeffrey T.

doi:10.1016/j.neuroscience.2006.08.080

Cited by 65 publications

(50 citation statements)

References 17 publications

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“…1 A). In accordance with previously published findings (Chan et al, 2007), we found that the vascular landmarks are more consistent than the bony bregma landmark between individual animals since they act as landmarks of the brain vasculature itself (Fig. 1 B) (RCSbregma coefficient of variation, 6.3%; RCS-LS coefficient of variation, 2.2%; n ϭ 46 mice).…”

Section: Localization Of the Longitudinal Hippocampal Arterysupporting

confidence: 92%

“…To assess the position of the artery we used two recently developed three-dimensional (3-D) digital mouse brain atlases (Chan et al, 2007;Dorr et al, 2007). We determined an optimal set of landmarks through the mouse skull, the lambda sinus (LS), and the rostral confluence of the nasal sinus (RCS), caudal to the olfactory bulb.…”

Section: Localization Of the Longitudinal Hippocampal Arterymentioning

confidence: 99%

“…1 B) (RCSbregma coefficient of variation, 6.3%; RCS-LS coefficient of variation, 2.2%; n ϭ 46 mice). To further optimize the stereotaxic coordinates, we individualized the coordinates by counting a ratio between the measured RCS-LS distance and the RCS-LS distance found in the 3-D digital mouse atlas (Chan et al, 2007;Dorr et al, 2007). The resulting factor served to optimize the stereotaxic coordinates in each individual experiment.…”

Section: Localization Of the Longitudinal Hippocampal Arterymentioning

confidence: 99%

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Changes in Hippocampal Neuronal Activity During and After Unilateral Selective Hippocampal IschemiaIn Vivo

Barth¹,

Módy²

2011

J. Neurosci.

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The hippocampal formation is one of the brain regions most sensitive to ischemic damage. However, there are no studies about changes in hippocampal neuronal activity during and after a selective unilateral hippocampal ischemia. We developed a novel unilateral cerebrovascular ischemia model in mice that selectively shuts down blood supply to the ipsilateral hippocampal formation. Using a modified version of the photothrombotic method, we stereotaxically targeted the initial ascending part of the longitudinal hippocampal artery in urethane anesthetized and rose bengal-injected mice. To block blood flow in the targeted artery, we photoactivated the rose bengal by illuminating the longitudinal hippocampal artery through an optical fiber inserted into the brain. In vivo field potential recordings in the CA1 region of the hippocampus before, during and after the induction of ischemia demonstrated a high-frequency discharge (HFD) reaching frequencies of Ͼ300 Hz and lasting 7-24 s during the illumination consistent with a massive synchronous neuronal activity. The HFD was invariably followed by a DC voltage shift and a decreased activity at both low (30 -57 Hz)-and high (63-119 Hz)-gamma frequencies. This decrease in gamma activity lasted for the entire duration of the recordings (ϳ160 min) following ischemia. The contralateral hippocampus displayed HFDs but with different frequency spectra and without DC voltage shifts or long-lasting decreases in gamma oscillations. Our findings reveal for the first time the acute effects of unilateral hippocampal ischemia on ensemble hippocampal neuronal activities.

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Section: Localization Of the Longitudinal Hippocampal Arterysupporting

confidence: 92%

Section: Localization Of the Longitudinal Hippocampal Arterymentioning

confidence: 99%

Section: Localization Of the Longitudinal Hippocampal Arterymentioning

confidence: 99%

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Changes in Hippocampal Neuronal Activity During and After Unilateral Selective Hippocampal IschemiaIn Vivo

Barth¹,

Módy²

2011

J. Neurosci.

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“…AMIRA (Mercury computer systems, Berlin, Germany) is a 3D modelling and visualisation system widely used for observation and quantification in several scientific disciplines [23][24][25] and physical anthropology [26][27][28][29][30][31][32][33][34][35][36]. It offers two kinds of surface extraction: one using an isosurface algorithm and the other using a segmented surface algorithm.…”

Section: Methodsmentioning

confidence: 99%

Three-dimensional computer-assisted craniometrics: A comparison of the uncertainty in measurement induced by surface reconstruction performed by two computer programs

Guyomarc’h¹,

Santos²,

Dutailly³

et al. 2012

Forensic Science International

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“…Such a tool enables group studies and makes possible the extraction of a huge amount of information from large dataset improving their analysis and comparison. Perspectives of this work will be the use of anatomical atlases [8] to treat massively large dataset and the possibility to integrate complementary information acquired post mortem (autoradiography, histology) [9,10] or in vivo (MRI high resolution) [11] in 3 dimensions.…”

Section: Discussionmentioning

confidence: 99%

Fully Automated and Adaptive Detection of Amyloid Plaques in Stained Brain Sections of Alzheimer Transgenic Mice

Feki

Teboul

Dubois³

et al.

Medical Image Computing and Computer-Assisted Intervention – MICCAI 2007

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Abstract. Automated detection of amyloid plaques (AP) in post mortem brain sections of patients with Alzheimer disease (AD) or in mouse models of the disease is a major issue to improve quantitative, standardized and accurate assessment of neuropathological lesions as well as of their modulation by treatment. We propose a new segmentation method to automatically detect amyloid plaques in Congo Red stained sections based on adaptive thresholds and a dedicated amyloid plaque/tissue modelling. A set of histological sections focusing on anatomical structures was used to validate the method in comparison to expert segmentation. Original information concerning global amyloid load have been derived from 6 mouse brains which opens new perspectives for the extensive analysis of such a data in 3-D and the possibility to integrate in vivo-post mortem information for diagnosis purposes.

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Development of a high resolution three-dimensional surgical atlas of the murine head for strains 129S1/SvImJ and C57Bl/6J using magnetic resonance imaging and micro-computed tomography

Cited by 65 publications

References 17 publications

Changes in Hippocampal Neuronal Activity During and After Unilateral Selective Hippocampal IschemiaIn Vivo

Changes in Hippocampal Neuronal Activity During and After Unilateral Selective Hippocampal IschemiaIn Vivo

Three-dimensional computer-assisted craniometrics: A comparison of the uncertainty in measurement induced by surface reconstruction performed by two computer programs

Fully Automated and Adaptive Detection of Amyloid Plaques in Stained Brain Sections of Alzheimer Transgenic Mice

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