DEVELOPMENT OF A HIGHLY INFECTIVE <i>BABESIA BIGEMINA</i> VACCINE OF REDUCED VIRULENCE

Dalgliesh, R.J.; Callow, L. L.; Mellors, L.T.; Mcgregor, W. S.

doi:10.1111/j.1751-0813.1981.tb07075.x

Cited by 67 publications

(18 citation statements)

References 8 publications

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“…Vaccination with attenuated live parasites has been demonstrated to be the most effective control measure against babesiosis. 61‐64 The vaccine produced from blood of infected cattle contains live B. bovis 65 or B. bigemina , 62 attenuated by rapid or by slow passages, respectively, in splenectomized calves. Although highly effective and satisfactory in many respects, these calf‐derived vaccines present serious drawbacks.…”

Section: Culture‐grown Babesia Sppmentioning

confidence: 99%

Culture‐Derived Parasites in Vaccination of Cattle against Tick‐Borne Diseases

Shkap¹,

Pipano²

2000

Annals of the New York Academy of Sciences

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The major economically important tick‐borne diseases of cattle are theileriosis, babesiosis, anaplasmosis, and cowdriosis. Culture‐derived attenuated schizonts of Theileria annulata have proved to be safe for all types of cattle and they protect against tick‐borne theileriosis. T. parva was also successfully grown in vitro; however, inoculation of cattle with allogeneic schizont‐infected cells resulted in rejection and destruction of the parasites together with the host cells. The number of schizont‐infected cells needed for immunization is greater than for T. annulata theileriosis. Culture‐propagated Babesia bovis and B. bigemina were used for large scale vaccination in the field. An avirulent population of Babesia spp. was obtained by in vitro cloning; inoculation of cattle did not induce clinical babesiosis, but produced specific antibodies. Culture‐derived exoantigens of Babesia spp. proved to be completely safe for cattle, however, they conferred less protection than live parasites. Cell‐cultured Cowdria ruminantium was highly infective for susceptible animals but, attenuated in vitro, could offer a potential source for vaccination. Anaplasma marginale, successfully grown in tick cell culture, may be developed for vaccines. Factors that should be considered in the developing of vaccines against tick‐borne diseases include: the protective immune response to the pathogenic parasite developmental stages, virulence, immunological strain differences, and antigenic variations in cattle and in culture.

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Section: Culture‐grown Babesia Sppmentioning

confidence: 99%

Culture‐Derived Parasites in Vaccination of Cattle against Tick‐Borne Diseases

Shkap¹,

Pipano²

2000

Annals of the New York Academy of Sciences

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“…The first attempts were directed in animals that were infected on purpose and healed from babesiosis as a strategy to avoid nondesirable infections [63]. Some studies were focused on trying to find a way to reduce the virulence of high infective B. bigemina strains through inoculum passages in several animals [64], and some even tried to immunize calves in utero [65]. As we know now, the development of a of an effective and low-cost vaccine is more complex than initially thought.…”

Section: Babesia Bigeminamentioning

confidence: 99%

Genome-Based Vaccinology Applied to Bovine Babesiosis

Mosqueda¹,

Hernández-Silva²,

MarioHidalgo-Ruiz³

2018

Farm Animals Diseases, Recent Omic Trends and New Strategies of Treatment

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Genomics approaches in veterinary research have been a very useful tool to identify candidates with potential to be used in prevention of animal diseases. In Babesia, genome information analysis has elucidated a wide variety of protein families and some members are described in this chapter. Here, we present some of the most recent studies about B. bovis and B. bigemina genomes where some proteins have been identified with potential to prevent infections by these parasites.

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“…This characteristic has been exploited to obtain avirulent strains by splenectomizing latently infected calves and using the resulting relapse parasites to repeat the procedure [36]. Both Babesia spp.…”

Section: Protective Immune Mechanismsmentioning

confidence: 99%