Development of a Highly Sensitive Imprinted Electrochemical Sensor for the Detection of Hydrocortisone in Wastewater

Cui, Xia; Han, Jili; Chen, Guoning; Wang, Lu; Luo, Zhimin; Chang, Chun; Zhang, Jia; Fu, Qiang

doi:10.1149/1945-7111/abfe42

Cited by 14 publications

(4 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For a miniature sensor device, it is possible to integrate fluidics capable of actuating the delivery of the redox probe liquid to the sensing site [41]. A convenient approach to circumvent the need for a fluidic delivery system is by embedding a redox probe within the MIP scaffold during the electropolymerization process [42,43].…”

Section: Introductionmentioning

confidence: 99%

Molecularly imprinted polymer on roll-to-roll printed electrodes as a single use sensor for monitoring of cortisol in sweat

Gillan

Jansson

2022

Flex. Print. Electron.

View full text Add to dashboard Cite

Cortisol is involved in regulating many human physiological functions, with cortisol imbalance capable of causing adverse mental and physical health conditions. Existing tools for monitoring of cortisol can assist in alerting the need for mediation strategies, but these typically require time consuming processes such as sample preparation followed by laboratory analysis. This work demonstrates a miniature flexible sensor patch incorporating electrode structures produced by high throughput roll-to-roll rotary screen-printing process, which are subsequently functionalized by electropolymerization of a polypyrrole/Prussian blue molecularly imprinted polymer for measuring cortisol by chronoamperometry. The developed single use sensor patch provides acceptable selectivity for cortisol and operates in artificial eccrine perspiration across a broad concentration range of 0.1-10000 ng/mL (R 2 = 0.916). In the application of measuring thermally induced sweat, the sensor provided results in agreement with the natural circadian rhythm of fluctuating cortisol.

show abstract

Section: Introductionmentioning

confidence: 99%

Molecularly imprinted polymer on roll-to-roll printed electrodes as a single use sensor for monitoring of cortisol in sweat

Gillan

Jansson

2022

Flex. Print. Electron.

View full text Add to dashboard Cite

show abstract

“…Studies have shown that the discharge of industrial sewage is considered to be one of the main sources of estrogen pollutant in the aquatic environment. 3,4 Among these, 17β-estradiol (E2), as one type of endocrine-disrupting chemical (EDC), has been detected in environment from different countries such as the United States, Germany, Italy, Brazil and China. [5][6][7] Therefore, the pollution of E2 in water environment has become a global pollution problem.…”

mentioning

confidence: 99%

Electrochemical Sensor Based on Poly-L-Tyrosine/AuNCs/PDA-CNTs Nanocomposites for the Detection of 17β-Estradiol in Wastewater

Guo¹,

Cui²,

Wang³

et al. 2022

J. Electrochem. Soc.

Self Cite

View full text Add to dashboard Cite

Achieving direct electrochemical detection of 17β-estradiol (E2) at low concentrations remains a challenge due to the weak electrochemical activity of E2. In this study, we report a simple, cheap, and sensitive electrochemical sensor based on nanocomposite for the direct detection of E2 in wastewater. The nanocomposite sensing electrode was developed by electrochemical in-situ polymerization. Due to the π-π stacking and hydrogen bonding between poly-L-tyrosine (P(L-tyr)) with E2, we prepared P(L-tyr) electrode based on dopamine-modified multi-walled carbon nanotubes (PDA-CNTs) and gold nanoclusters (AuNCs). Then P(L-tyr)/AuNCs/PDA-CNTs/GCE sensing system was obtained. Meanwhile, the synergistic effect of fast electron transfer of AuNCs and the signal amplification effect of PDA-CNTs enables sensitive and direct detection of E2. The results showed that P(L-tyr)/AuNCs/PDA-CNTs/GCE sensor had a linear response to E2 concentration from 0.05 to 10 μmol·L−1 with a detection limit of 7.1 nmol·L−1. Then, the trace amount of E2 in pharmaceutical wastewater samples can be directly detected against several interferences from complex matrix, with recoveries from 91.0 to 107.5%. P(L-tyr)/AuNCs/PDA-CNTs/GCE showed good stability when placed at room temperature. Therefore, it can meet the requirements of the sensitive detection of E2 in complex matrix.

show abstract

“…Our previous research has also reported a sensitive imprinted electrochemical sensor for the detection of HC with much low LOD of 0.006 nM. 37 However, DXM and HC were usually co-existed in aquatic matrices. Due to the weak electro-activity and similar structure of them, it remains a challenge to achieve simultaneous determination of DXM and HC using electrochemical sensing analysis.…”

mentioning

confidence: 99%

Development of Poly(L-arginine)/PSSA/QDs Modified Biosensor for Simultaneous Detection of Different Glucocorticoids in Wastewater

Luo¹,

He²,

Chen³

et al. 2022

J. Electrochem. Soc.

Self Cite

View full text Add to dashboard Cite

Due to poor electro-active and less structural differences of glucocorticoids, it is still a challenge to realize simultaneous electrochemical detection of different glucocorticoids in wastewater. Here an electrochemical biosensing platform was constructed through electrochemical in situ polymerization. A poly(sulphosalicylic acid) (PSSA) composite electrode was prepared based on polymerized L-arginine (Arg) doped with carbon quantum dots (QDs) and GCE-Arg-PSSA-QD sensor was obtained. Transmission electron microscopy, scanning electron microscopy, and an energy dispersive spectrometer were used to characterize the morphology and physical property of obtained electrodes. The PSSA layer mimics the sulfonated metabolism of glucocorticoids in vivo, allowing for direct reduction of glucocorticoids on the surface of electrode, thus enabling the capture of different glucocorticoids. Meanwhile, the fast electron transfer of QDs and the signal magnification effect of Arg allow a sensitive and direct detection of dexamethasone (DXM) and hydrocortisone (HC) simultaneously. Differential pulse voltammetry was used to investigate the analytical properties of prepared biosensing platform. The results show that GCE-Arg-PSSA-QD sensor delivered an analytical performance for both DXM and HC with a limit of detection of 9 nM and 37 nM. Then, the method was utilized for simultaneous detection of DXM and HC in real wastewater samples with favorable results.

show abstract

Development of a Highly Sensitive Imprinted Electrochemical Sensor for the Detection of Hydrocortisone in Wastewater

Cited by 14 publications

References 36 publications

Molecularly imprinted polymer on roll-to-roll printed electrodes as a single use sensor for monitoring of cortisol in sweat

Molecularly imprinted polymer on roll-to-roll printed electrodes as a single use sensor for monitoring of cortisol in sweat

Electrochemical Sensor Based on Poly-L-Tyrosine/AuNCs/PDA-CNTs Nanocomposites for the Detection of 17β-Estradiol in Wastewater

Development of Poly(L-arginine)/PSSA/QDs Modified Biosensor for Simultaneous Detection of Different Glucocorticoids in Wastewater

Contact Info

Product

Resources

About