Electrochemical Sensor Based on Poly-L-Tyrosine/AuNCs/PDA-CNTs Nanocomposites for the Detection of 17β-Estradiol in Wastewater

Guo, Miao; Cui, Xia; Wang, Lu; Yang, Ke; Xu, Jiameng; Yu, Liangwei; Luo, Zhimin; Zeng, Aiguo; Zhang, Jia; Fu, Qiang

doi:10.1149/1945-7111/ac9bde

Cited by 5 publications

(2 citation statements)

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“…Integrating AuNCs with other materials and nanostructures is an interesting route in designing high-performance electroanalysis devices. In these procedures, the excellent electrocatalytic properties of AuNCs combine with other materials for enhanced detection efficiency. , These strategies are usually based on the synergistic effects between AuNCs and other materials to enhance the electrocatalytic activity of AuNCs. Liu et al used BSA-AuCNs/MXene for electrochemical sensing of homocysteine (Hcy) in serum and rat lung cancer cell lysates.…”

Section: Metal Ncsmentioning

confidence: 99%

Metal Nanoclusters in Point-of-Care Sensing and Biosensing Applications

Nasrollahpour

Jurado‐Sánchez

Moradi

2023

ACS Appl. Nano Mater.

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Nanoclusters are nanostructures consisting of few to tens of atoms which have attracted great interest from the scientific community due to their applications in a myriad of fields, from catalysis to biomedical applications. Due to the discrete energy levels resulting from their ultrasmall size, nanoclusters exhibit distinctly different chemical, optical, and electrical properties compared with their larger nanoparticle counterparts. Unlike previously reported nanostructures with larger dimensions (1–10 nm), which typically have a single advantage (for example, high conductivity or optical properties), nanoclusters can be used as signaling and/or reaction-accelerating materials in almost all sensing assays with enhanced properties. Nanoclusters are among the most promising luminescent emitters (electrochemiluminescent, fluorescent, chemiluminescent, and colorimetry) with high quantum yield and better biocompatibility than conventional emitters. Considering their excelent biocompatibility, tailored modification, and desirable electrochemical and optical tunability, nanoclusters have opened new horizons in designing high-performance sensing and biosensing devices. In addition, they represent excellent electrochemical and photoelectrochemical behaviors with improved functionality and environmentally friendly properties compared to traditional compounds. This review discusses the recent advances in nanoclusters, their applications in sensing and biosensing, current limitations, and prospects to overcome these challenges. The present study gives a much brighter vision of nanoclusters that discusses one by one their particular advantages and role in developing sensing frameworks.

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Section: Metal Ncsmentioning

confidence: 99%

Metal Nanoclusters in Point-of-Care Sensing and Biosensing Applications

Nasrollahpour

Jurado‐Sánchez

Moradi

2023

ACS Appl. Nano Mater.

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“…Recently, the human-urine-based detection of E2 for its early diagnosis is gaining more popularity due to its patient-friendly and comfortable assay in comparison with serum-based assays [17][18][19][20][21], despite the fact that the E2 concentration present in human urine is much smaller than that in human serum [22]. As solutions to the aforementioned challenges associated with the limited sensitivity available from existing sensor strategies, attempts have been made with various detection mechanisms, such as plasmonic-nanoparticle-based sensors [23][24][25][26][27], fluorescence sensors [28][29][30][31][32], Raman-based sensors [33][34][35][36][37][38], electrochemical sensors [39][40][41][42][43][44][45][46][47][48][49], enzyme immunosensors [50,51], and others [52][53][54][55][56][57][58][59]. To achieve a limit of detection (LOD) of E2 comparable or lower than 1 pg/mL, most of the ultrahigh-sensitivity E2 sensors have employed signal amplification mechanisms t...…”

Section: Introductionmentioning

confidence: 99%

Ultrahigh-Sensitivity Detection of 17β-Estradiol

Seok,

2024

Chemosensors

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17β-estradiol (E2), a vital female sex hormone, plays a crucial role in female reproductive cycles and secondary sexual characteristics. The quantification of E2 concentration in human blood and urine samples is essential because a deviation from physiological levels of E2 indicates the development of diseases and abnormalities such as precocious puberty, breast cancer, weight gain, abnormal menstruation, osteoporosis, and infertility. In addition, the detection of E2 in food and the environment has gained widespread interest because of its role as an endocrine disruptor (environmental hormone) that can perturb physiological processes. E2 is used as a drug for hormone therapy. Various E2 detection technologies for diagnosing relevant human diseases, drug screening, and environmental monitoring have been demonstrated in studies. In this article, we have reviewed technological strategies developed for E2 detection with ultrahigh sensitivity, with a limit of detection comparable to several pg/mL or lower. We observed that gold nanoparticles (AuNPs) were used as nanoplatforms for signal amplification, which enabled ultrahigh sensitivity in most studies. Signal amplification was facilitated by AuNP characteristics such as the versatility of surface biochemistry, exceedingly large surface-to-volume ratio, surface plasmonic activity, luminescence quenching ability, and biocompatibility. These techniques have been used to detect E2 in food, water, human serum, and urine with ultrahigh sensitivity. We summarize the working principles of E2 detection strategies that allow ultrahigh sensitivity and provide an approach for future work required for the elucidation of practical applications of these technologies.

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Key role of adsorption site abundance in the direct electrochemical co-detection of estradiol and dopamine

Delmo,

Pande,

Peltola

2024

Discover Nano

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Estradiol (E2) is a hormone that influences various aspects of women’s health. Beyond its reproductive functions, E2 impacts neurotransmitter systems such as dopamine (DA). Vertically aligned carbon nanofibers (VACNFs) have shown good sensitivity, selectivity against ascorbic acid (AA) and uric acid (UA), biocompatibility, and reduced fouling in DA sensing. In this study, we explore the use of Ti-Ni-CNF electrodes with CNFs grown for 5 min and 30 min for the direct electrochemical co-detection of E2 and DA. The longer growth time led to a 142% increase in average CNF length and a 36% larger electroactive surface area. In E2 detection, the electrodes demonstrate a wide linear range of 0.05–10 µM and sensitivity of 0.016 and 0.020 µA/µM for Ti-Ni-CNF-5 min and Ti-Ni-CNF-30 min, respectively. The sensor performance remains largely unaffected even in the presence of other steroid hormones such as progesterone and testosterone. Co-detection of equimolar E2 and DA shows promising peak separation of 0.34 ± 0.01 V and repeatability after 10 measurements. A notable improvement in the E2/DA peak current ratio, from 0.53 ± 0.07 to 0.81 ± 0.16, was achieved with the increased CNF length. Our results demonstrate the influence of adsorption sites in electrochemical detection, especially for analytes such as E2 and DA that both rely on adsorption for oxidation. While detecting small and fluctuating physiological concentrations remains a challenge, these findings can be used in choosing and fabricating electrode materials for more accurate and accessible continuous hormone measurements, including the possibility of multianalyte sensing platforms. Graphic abstract

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Electrochemical Sensor Based on Poly-L-Tyrosine/AuNCs/PDA-CNTs Nanocomposites for the Detection of 17β-Estradiol in Wastewater

Cited by 5 publications

References 50 publications

Metal Nanoclusters in Point-of-Care Sensing and Biosensing Applications

Metal Nanoclusters in Point-of-Care Sensing and Biosensing Applications

Ultrahigh-Sensitivity Detection of 17β-Estradiol

Key role of adsorption site abundance in the direct electrochemical co-detection of estradiol and dopamine

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