Development of a hybrid peptide dendrimer micellar carrier system and its application in the reformulation of a hydrophobic therapeutic agent derived from traditional Chinese medicine

Abstract

A novel amphiphilic peptide dendrimer-based delivery system was developed for a cane toad poison-derived steroid. The methodology to incorporate lipid into asymmetric dendrimers generated self-assembled micelles.

Advances on Delivery System of Active Ingredients of Dried Toad Skin and Toad Venom

“…Therefore, polymer micelles are of great interest in TDDS. 76–78 Jing et al 50 prepared BU-micelle inclusion complex by co-precipitation, which is an amphiphilic dendritic polymer-based delivery system that can solve the problems of poor water solubility and tissue deposition characteristics of BU. The critical micelle concentration was determined to be 105.38 μ·mol −1 , with micelle size of 130 nm.…”

Self-assembly of Peptide dendrimers and their bio-applications in theranostics

“…The arginine-rich dendritic lipopeptides could be further integrated with the hydrophobic drugs to increase their solubility. In detail, the lipidated Arg4 + dendrimers were assembled into discrete micelles in an aqueous environment, and the bufalin-micelle inclusion complex was prepared by the co-precipitation method [ 57 ]. These peptide-dendrimer hybrids are of fundamental interest to investigate the role of polymer architecture on self-assembly, and can exhibit advantages in applications.…”

“…Parekh et al. designed an arginine-terminated lipid dendrimers for encapsulation of the negatively charged bufalin to improve its solubility [ 57 ]. The self-assembled bufalin-containing micelles showed a more than threefold increase in the aqueous solubility (142.9 ​μg ​mL −1 ) of bufalin, when compared with a saturated bufalin aqueous solution (42.4 ​μg ​mL −1 ).…”