Development of a hydrophilic molecularly imprinted polymer for the detection of hydrophilic targets using quartz crystal microbalance

Dayal, Hiranya; Ng, Wan Yi; Lin, Xuan; Li, Sam Fong Yau

doi:10.1016/j.snb.2019.127044

Cited by 18 publications

(8 citation statements)

References 62 publications

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“…A scheme of a QCM chip and the corresponding sensogram are shown in Scheme 2a. QCM sensors have been widely used for the detection of steroid hormones such as nandrolone [78] and neurotransmitters such as catecholamines [79], as well as for other analytes like the β-blocking drug (S)propranolol [80], caffeine [81], trichlorfon [82], α-amanitin [83], N-hexanoyl-L-homoserine lactone [84], and L-tryptophan [85]. The experimental characteristics of the sensors detecting these analytes are summarized in Table 2.…”

Section: Qcm Sensorsmentioning

confidence: 99%

“…The experimental characteristics of the sensors detecting these analytes are summarized in Table 2. Molecularly imprinted films on top of a QCM can be made using the drop-casting by embedding the preformed MIP nanoparticles (NPs) into a polymer matrix [78,79], covalent immobilizing via coupling reactions [84], in situ polymerizing [80], or imprinting onto preformed polymers [81,82]. 1 Crushed and sieved particles and film; 2 Crushed and sieved particles embedded in a PVC matrix.…”

Section: Qcm Sensorsmentioning

confidence: 99%

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Molecularly Imprinted Polymers for Chemical Sensing: A Tutorial Review

et al. 2021

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The field of molecularly imprinted polymer (MIP)-based chemosensors has been experiencing constant growth for several decades. Since the beginning, their continuous development has been driven by the need for simple devices with optimum selectivity for the detection of various compounds in fields such as medical diagnosis, environmental and industrial monitoring, food and toxicological analysis, and, more recently, the detection of traces of explosives or their precursors. This review presents an overview of the main research efforts made so far for the development of MIP-based chemosensors, critically discusses the pros and cons, and gives perspectives for further developments in this field.

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Section: Qcm Sensorsmentioning

confidence: 99%

Section: Qcm Sensorsmentioning

confidence: 99%

Molecularly Imprinted Polymers for Chemical Sensing: A Tutorial Review

et al. 2021

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“…Investigators recently described a unique sensor fabrication obviating the tedium of polymerization (205). This is achieved with commercially available poly(vinylidene difluoride) (PVDF) and chemically modifying it from its native hydrophobicity for compatibility with the hydrophilic trichlorfon (TCF) analyte, a dangerous pesticide requiring food monitoring.…”

Section: Gravimetric Transductionmentioning

confidence: 99%

Point-of-Care Diagnostics: Molecularly Imprinted Polymers and Nanomaterials for Enhanced Biosensor Selectivity and Transduction

Denmark

Mohapatra

2020

The EuroBiotech Journal

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Significant healthcare disparities resulting from personal wealth, circumstances of birth, education level, and more are internationally prevalent. As such, advances in biomedical science overwhelmingly benefit a minority of the global population. Point-of-Care Testing (POCT) can contribute to societal equilibrium by making medical diagnostics affordable, convenient, and fast. Unfortunately, conventional POCT appears stagnant in terms of achieving significant advances. This is attributed to the high cost and instability associated with conventional biorecognition: primarily antibodies, but nucleic acids, cells, enzymes, and aptamers have also been used. Instead, state-of-the-art biosensor researchers are increasingly leveraging molecularly imprinted polymers (MIPs) for their high selectivity, excellent stability, and amenability to a variety of physical and chemical manipulations. Besides the elimination of conventional bioreceptors, the incorporation of nanomaterials has further improved the sensitivity of biosensors. Herein, modern nanobiosensors employing MIPs for selectivity and nanomaterials for improved transduction are systematically reviewed. First, a brief synopsis of fabrication and wide-spread challenges with selectivity demonstration are presented. Afterward, the discussion turns to an analysis of relevant case studies published in the last five years. The analysis is given through two lenses: MIP-based biosensors employing specific nanomaterials and those adopting particular transduction strategies. Finally, conclusions are presented along with a look to the future through recommendations for advancing the field. It is hoped that this work will accelerate successful efforts in the field, orient new researchers, and contribute to equitable health care for all.

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“…The idea of integrating MIPs as selective recognition layers in sensing devices and assays emerged in the 90 s, coupling MIPs to traditional biosensor readout technologies that act as transducers translating molecular binding into a measurable signal [ 42 , 43 ]. Advancements in MIP synthesis procedures, micro-electronics and computation have accelerated this evolution over the past twenty years, with many new sensor and assay platforms emerging [ [44] , [45] , [46] ]. A variety of approaches ensued, with readout methods including but not limited to quartz crystal microbalances (QCM), electrochemical sensors (e.g.…”

Section: Introductionmentioning

confidence: 99%

MIPs for commercial application in low-cost sensors and assays – An overview of the current status quo

Lowdon

Diliën

Singla

et al. 2020

Sensors and Actuators B: Chemical

183

103

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Highlights The review aims to summarize recent commercially interesting innovations in MIP-based sensor design. In addition to sensors, commercially viable assays based on MIPs are analysed and recent advances are summarized and discussed. The review also analyses how commercial MIP companies could contribute to a next step in the commercialization of MIP-based detection systems. The review contains a critical analysis and discussion on MIP-based sensors and assay commercialization as well as an outlook/recommendation for the future.

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Development of a hydrophilic molecularly imprinted polymer for the detection of hydrophilic targets using quartz crystal microbalance

Cited by 18 publications

References 62 publications

Molecularly Imprinted Polymers for Chemical Sensing: A Tutorial Review

Molecularly Imprinted Polymers for Chemical Sensing: A Tutorial Review

Point-of-Care Diagnostics: Molecularly Imprinted Polymers and Nanomaterials for Enhanced Biosensor Selectivity and Transduction

MIPs for commercial application in low-cost sensors and assays – An overview of the current status quo

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