Molecularly Imprinted Polymers for Chemical Sensing: A Tutorial Review

Leibl, Nadja; Haupt, Karsten; Gonzato, Carlo; Duma, Luminita

doi:10.3390/chemosensors9060123

Cited by 124 publications

(70 citation statements)

References 148 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this context, a wealth of different synthetic strategies were presented to facilitate the design of efficient, imprinted materials for the application of interest. More detailed explanations of the synthesis, application, and limitations of MIPs can be found recent reviews [ 2 , 12 , 14 , 17 , 24 , 27 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 ].…”

Section: Introductionmentioning

confidence: 99%

Artificial Biomimetic Electrochemical Assemblies

et al. 2022

View full text Add to dashboard Cite

Rapid, selective, and cost-effective detection and determination of clinically relevant biomolecule analytes for a better understanding of biological and physiological functions are becoming increasingly prominent. In this regard, biosensors represent a powerful tool to meet these requirements. Recent decades have seen biosensors gaining popularity due to their ability to design sensor platforms that are selective to determine target analytes. Naturally generated receptor units have a high affinity for their targets, which provides the selectivity of a device. However, such receptors are subject to instability under harsh environmental conditions and have consequently low durability. By applying principles of supramolecular chemistry, molecularly imprinted polymers (MIPs) can successfully replace natural receptors to circumvent these shortcomings. This review summarizes the recent achievements and analytical applications of electrosynthesized MIPs, in particular, for the detection of protein-based biomarkers. The scope of this review also includes the background behind electrochemical readouts and the origin of the gate effect in MIP-based biosensors.

show abstract

Section: Introductionmentioning

confidence: 99%

Artificial Biomimetic Electrochemical Assemblies

et al. 2022

View full text Add to dashboard Cite

show abstract

“…MIPs are characterized by very interesting properties such as physical resistance, robustness, resistance to high pressures and temperatures and high inertia towards various chemicals. In addition, MIPs have high affinity and selectivity towards target molecules; they are comparable to natural receptors [13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Mathematical Modelling of Glyphosate Molecularly Imprinted Polymer-Based Microsensor with Multiple Phenomena

et al. 2022

View full text Add to dashboard Cite

The massive and careless use of glyphosate (GLY) in agricultural production raises many questions regarding environmental pollution and health risks, it is then important to develop simple methods to detect it. Electrochemical impedance spectroscopy (EIS) is an effective analytical tool for characterizing properties at the electrode/electrolyte interface. It is useful as an analytical procedure, but it can also help in the interpretation of the involved fundamental electrochemical and electronic processes. In this study, the impedance data obtained experimentally for a microsensor based on molecularly imprinted chitosan graft on 4-aminophenylacetic acid for the detection of glyphosate was analyzed using an exact mathematical model based on physical theories. The procedure for modeling experimental responses is well explained. The analysis of the observed impedance response leads to estimations of the microscopic parameters linked to the faradic and capacitive current. The interaction of glyphosate molecules with the imprinted sites of the CS-MIPs film is observed in the high frequency range. The relative variation of the charge transfer resistance is proportional to the log of the concentration of glyphosate. The capacitance decreases as the concentration of glyphosate increases, which is explained by the discharging of the charged imprinted sites when the glyphosate molecule interacts with the imprinted sites through electrostatic interactions. The phenomenon of adsorption of the ions in the CMA film is observed in the low frequency range, this phenomenon being balanced by the electrostatic interaction of glyphosate with the imprinted sites in the CS-MIPs film.

show abstract

“…Molecularly imprinted polymers (MIPs) are prepared using the target molecules as templates to produce receptor sites. After removing the template, the target molecules can be selectively captured [17][18][19][20][21]. Castro-Grijalba et al developed a SERS sensor through spin-coating MIP to form thin film for polycyclic aromatic hydrocarbons (PAHs) detection [22].…”

Section: Introductionmentioning

confidence: 99%

SERS Gas Sensors Based on Multiple Polymer Films with High Design Flexibility for Gas Recognition

Chen

Guo

Sassa

et al. 2021

Sensors

View full text Add to dashboard Cite

The Surface-Enhanced Raman Scattering (SERS) technique is utilized to fabricate sensors for gas detection due to its rapid detection speed and high sensitivity. However, gases with similar molecular structures are difficult to directly discriminate using SERS gas sensors because there are characteristic peak overlaps in the Raman spectra. Here, we proposed a multiple SERS gas sensor matrix via a spin-coating functional polymer to enhance the gas recognition capability. Poly (acrylic acid) (PAA), Poly (methyl methacrylate) (PMMA) and Polydimethylsiloxane (PDMS) were employed to fabricate the polymer film. The high design flexibility of the two-layer film was realized by the layer-by-layer method with 2 one-layer films. The SERS gas sensor coated by different polymer films showed a distinct affinity to target gases. The principle component analysis (PCA) algorithm was used for the further clustering of gas molecules. Three target gases, phenethyl alcohol, acetophenone and anethole, were perfectly discriminated, as the characteristic variables in the response matrix constructed by the combination of gas responses obtained 3 one-layer and 3 two-layer film-coated sensors. This research provides a new SERS sensing approach for recognizing gases with similar molecular structures.

show abstract

Molecularly Imprinted Polymers for Chemical Sensing: A Tutorial Review

Cited by 124 publications

References 148 publications

Artificial Biomimetic Electrochemical Assemblies

Artificial Biomimetic Electrochemical Assemblies

Mathematical Modelling of Glyphosate Molecularly Imprinted Polymer-Based Microsensor with Multiple Phenomena

SERS Gas Sensors Based on Multiple Polymer Films with High Design Flexibility for Gas Recognition

Contact Info

Product

Resources

About