Artificial Biomimetic Electrochemical Assemblies

Zidarič, Tanja; Finšgar, Matjaž; Maver, Uroš; Maver, Tina

doi:10.3390/bios12010044

Cited by 16 publications

(16 citation statements)

References 172 publications

(479 reference statements)

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“…When added to the target, the target binds specifically to the cavity, enabling detection of the target [ 109 ]. The greatest advantage of MIPs over biomolecules is their ability to maintain functional stability in relatively harsh environments [ 110 ], and the use of MIPs enables the capture of a wide range of targets, from small molecules to large molecular entities, such as pathogens and whole cells [ 111 , 112 , 113 ]. Therefore, the demand for MIPs in the field of biosensors development is increasing recently and there is a significant improvement.…”

Section: New Strategies For Biosensormentioning

confidence: 99%

A Review of Biosensors for Detecting Tumor Markers in Breast Cancer

Hong

Sun

et al. 2022

Life

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Breast cancer has the highest cancer incidence rate in women. Early screening of breast cancer can effectively improve the treatment effect of patients. However, the main diagnostic techniques available for the detection of breast cancer require the corresponding equipment, professional practitioners, and expert analysis, and the detection cost is high. Tumor markers are a kind of active substance that can indicate the existence and growth of the tumor. The detection of tumor markers can effectively assist the diagnosis and treatment of breast cancer. The conventional detection methods of tumor markers have some shortcomings, such as insufficient sensitivity, expensive equipment, and complicated operations. Compared with these methods, biosensors have the advantages of high sensitivity, simple operation, low equipment cost, and can quantitatively detect all kinds of tumor markers. This review summarizes the biosensors (2013–2021) for the detection of breast cancer biomarkers. Firstly, the various reported tumor markers of breast cancer are introduced. Then, the development of biosensors designed for the sensitive, stable, and selective recognition of breast cancer biomarkers was systematically discussed, with special attention to the main clinical biomarkers, such as human epidermal growth factor receptor-2 (HER2) and estrogen receptor (ER). Finally, the opportunities and challenges of developing efficient biosensors in breast cancer diagnosis and treatment are discussed.

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Section: New Strategies For Biosensormentioning

confidence: 99%

A Review of Biosensors for Detecting Tumor Markers in Breast Cancer

Hong

Sun

et al. 2022

Life

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“…In addition, they are widely used in the field of clinical drug analysis and biomimetic sensing [ 12 ]. Recently, it has been used as artificial biomimetic material, such as artificial antibodies (plastibodies), enzymes and other biological molecules [ 13 , 14 , 15 , 16 ]. The basic principle of molecular imprinting is mainly based on Pauling’s theory of bioimprinting and the lock-and-key concept [ 17 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Application of Molecularly Imprinted Polymers for Flavonoids: Review and Perspective

Yang

Shen

2022

Molecules

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The separation and detection of flavonoids from various natural products have attracted increasing attention in the field of natural product research and development. Depending on the high specificity of molecularly imprinted polymers (MIPs), MIPs are proposed as efficient adsorbents for the selective extraction and separation of flavonoids from complex samples. At present, a comprehensive review article to summarize the separation and purification of flavonoids using molecular imprinting, and the employment of MIP-based sensors for the detection of flavonoids is still lacking. Here, we reviewed the general preparation methods of MIPs towards flavonoids, including bulk polymerization, precipitation polymerization, surface imprinting and emulsion polymerization. Additionally, a variety of applications of MIPs towards flavonoids are summarized, such as the different forms of MIP-based solid phase extraction (SPE) for the separation of flavonoids, and the MIP-based sensors for the detection of flavonoids. Finally, we discussed the advantages and disadvantages of the current synthetic methods for preparing MIPs of flavonoids and prospected the approaches for detecting flavonoids in the future. The purpose of this review is to provide helpful suggestions for the novel preparation methods of MIPs for the extraction of flavonoids and emerging applications of MIPs for the detection of flavonoids from natural products and biological samples.

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“…When MIP technology is combined with electrochemical detection, the development of inexpensive and portable sensor devices is possible. In the literature, different monomer systems for imprinting IDP have been evaluated, including the conventional polyacrylate polymer system [ 27 ] and chitosan [ 28 , 29 ]. However, these MIP polymers impede electrochemical detection due to their electrically insulative properties.…”

Section: Introductionmentioning

confidence: 99%

Molecularly Imprinted Polymer-Modified Microneedle Sensor for the Detection of Imidacloprid Pesticides in Food Samples

Mugo¹,

Lu²,

Robertson³

2022

Sensors

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A portable, molecularly imprinted polymer (MIP)-based microneedle (MN) sensor for the electrochemical detection of imidacloprid (IDP) has been demonstrated. The MN sensor was fabricated via layer-by-layer (LbL) in-tube coating using a carbon nanotube (CNT)/cellulose nanocrystal (CNC) composite, and an IDP-imprinted polyaniline layer co-polymerized with imidazole-functionalized CNCs (PANI-co-CNC-Im) as the biomimetic receptor film. The sensor, termed MIP@CNT/CNC MN, was analyzed using both cyclic voltammetry (CV) and differential pulse voltammetry (DPV) and showed excellent electrochemical performance for the detection of IDP. The CV detection range for IDP was 2.0–99 µM, with limits of detection (LOD) of 0.35 µM, while the DPV detection range was 0.20–92 µM with an LOD of 0.06 µM. Additionally, the MIP@CNT/CNC MN sensor showed excellent reusability and could be used up to nine times with a 1.4 % relative standard deviation (% RSD) between uses. Lastly, the MIP@CNT/CNC MN sensor successfully demonstrated the quantification of IDP in a honey sample.

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Artificial Biomimetic Electrochemical Assemblies

Cited by 16 publications

References 172 publications

A Review of Biosensors for Detecting Tumor Markers in Breast Cancer

A Review of Biosensors for Detecting Tumor Markers in Breast Cancer

Preparation and Application of Molecularly Imprinted Polymers for Flavonoids: Review and Perspective

Molecularly Imprinted Polymer-Modified Microneedle Sensor for the Detection of Imidacloprid Pesticides in Food Samples

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