Prewetting process can reduce the contact angle between the droplet and the leaf blade, so that the droplet can more easily wet and spread, thereby increasing the quantity of deposition. To improve the effectiveness of pesticides on cotton leaves, prewetting by single-rotor electric unmanned aerial vehicles (UAV) was studied, focusing on the effects of pesticide deposition on cotton leaves during the flowering period. Cotton leaves in 0°-30°, 30°-60°, 60°-90°leaf blade angle ranges (angle between the leaf blade and the horizontal plane) were examined. In the first experiment, four different prewetting volumes (0, 1.6, 3.2 and 4.8 L) were sprayed by a singlerotor electric UAV on four cotton plots (plots A-D) each with an area of 120 m 2 , and then each area was sprayed with a 0.8% (w/v) ponceau 2R solution by another singlerotor electric UAV. The results revealed that with no prewetting, droplet deposition quantity decreased with increasing leaf blade inclination. After prewetting, the mean droplet deposition quantity on plots B, C and D increased by 39.8%, 9.7% and 24.9%, respectively. The prewetting rate of 1.6 L per 120 m 2 had the most significant effect on improving the deposition of droplets. It was also found that the mean droplet deposition quantity in each leaf blade angle range increased after prewetting. For the leaf blade angle range 60°-90°, this increase was the most pronounced, with 0.043, 0.062, 0.057 and 0.048 mL$cm -2 in plots A-D, respectively. Also, droplet deposition uniformity in the leaf blade angle range 60°-90°was better after prewetting. These results should provide a valuable reference for future research and practice to improve the effectiveness of pesticides applied to cotton by aerial applications.