Development of a micro dosing system for fine powder using a vibrating capillary. Part 1: The investigation of factors influencing on the dosing performance

Chen, Xiaolong; Seyfang, Karlheinz; Steckel, Hartwig

doi:10.1016/j.ijpharm.2012.04.068

Cited by 15 publications

(5 citation statements)

References 16 publications

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“…Combining several nozzles equipped with different hoppers filled with various powder materials enables the arbitrary deposition of powders into the build chamber [19]. By adjusting the piezoelectric excitation, powder flow properties, surface quality of the sliding surface of the nozzle, cone angle, and orifice diameter, continuous flow and a valve-like start and stop function can be achieved [18,20,21]. However, according to [22], the processing efficiency of nozzle-based powder application processes is relatively low.…”

Section: Laser-based Additive Manufacturing Of Thermoplastic Multi-ma...mentioning

confidence: 99%

Innovative Process Strategies in Powder-Based Multi-Material Additive Manufacturing

Setter

Hafenecker

Rothfelder

et al. 2023

JMMP

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Multi-material additive manufacturing (AM) attempts to utilize the full benefits of complex part production with a comprehensive and complementary material spectrum. In this context, this research article presents new processing strategies in the field of polymer- and metal-based multi-material AM. The investigation highlights the current progress in powder-based multi-material AM based on three successfully utilized technological approaches: additive and formative manufacturing of hybrid metal parts with locally adapted and tailored properties, material-efficient AM of multi-material polymer parts through electrophotography, and the implementation of UV-curable thermosets within the laser-based powder bed fusion of plastics. Owing to the complex requirements for the mechanical testing of multi-material parts with an emphasis on the transition area, this research targets an experimental shear testing set-up as a universal method for both metal- and polymer-based processes. The method was selected based on the common need of all technologies for the sufficient characterization of the bonding behavior between the individual materials.

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Section: Laser-based Additive Manufacturing Of Thermoplastic Multi-ma...mentioning

confidence: 99%

Innovative Process Strategies in Powder-Based Multi-Material Additive Manufacturing

Setter

Hafenecker

Rothfelder

et al. 2023

JMMP

View full text Add to dashboard Cite

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“…However, low‐dose capsule filling is not trivial and only a few systems exist that have reached the technical maturity. They are typically not used for routine manufacturing but are rather applied in small‐scale clinical studies and during development phases that typically involve vibrating capillaries . Examples include the Capsugel Xcelodose micro‐dosing system and the micro‐dosing system by MG2.…”

Section: Perspective To Future Process Philosophymentioning

confidence: 99%

“…They are typically not used for routine manufacturing but are rather applied in small-scale clinical studies and during development phases that typically involve vibrating capillaries. 314,315 Examples include the Capsugel Xcelodose micro-dosing system and the micro-dosing system by MG2. In both cases, vibrations are used to dose small amounts of powder.…”

Section: Future Manufacturing Technologiesmentioning

confidence: 99%

The Future of Pharmaceutical Manufacturing Sciences

Rantanen

Khinast

2015

Journal of Pharmaceutical Sciences

362

152

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The entire pharmaceutical sector is in an urgent need of both innovative technological solutions and fundamental scientific work, enabling the production of highly engineered drug products. Commercial‐scale manufacturing of complex drug delivery systems (DDSs) using the existing technologies is challenging. This review covers important elements of manufacturing sciences, beginning with risk management strategies and design of experiments (DoE) techniques. Experimental techniques should, where possible, be supported by computational approaches. With that regard, state‐of‐art mechanistic process modeling techniques are described in detail. Implementation of materials science tools paves the way to molecular‐based processing of future DDSs. A snapshot of some of the existing tools is presented. Additionally, general engineering principles are discussed covering process measurement and process control solutions. Last part of the review addresses future manufacturing solutions, covering continuous processing and, specifically, hot‐melt processing and printing‐based technologies. Finally, challenges related to implementing these technologies as a part of future health care systems are discussed. © 2015 The Authors. Journal of Pharmaceutical Sciences published by Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 104:3612–3638, 2015

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“…An agitating device [9], an oscillating sieve [10], or vibrations were applied to dose the desired amount of powder. To avoid bridging and blocking, feeding through capillaries was performed using vibrations either via acoustic or ultrasound generation [11][12][13][14][15]. The feed rate is controlled by the orifice diameter and the frequency and amplitude of the oscillation.…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of a Novel Micro-feeder and Loss-in-weight Feeders

2021

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Purpose Accurate and reliable feeding of small quantities of powder is crucial in many industries. It is particularly true in the case of pharmaceutical manufacturing. First, the exact dosage of highly potent active pharmaceutical ingredients (APIs) is essential. Second, due to the shift towards continuous manufacturing, processing agents must be supplied continuously. Last, with regard to personalized medicine products, small doses of API have to be processed with high flexibility. In all these applications, a few grams of powder or less per hour have to be fed, which makes processing very challenging. The common route of pre-blending causes additional effort in processing and quality control compared to direct continuous feeding, while material properties influence the performance of conventional feeders with conveying screw elements. Methods In this study, a novel micro-feeding system based on active volumetric displacement is investigated and compared to commercial LIW feeders of various scales. In the micro-feeder, the powder is filled into a cylindrical cartridge and pushed towards the process by a piston in a controlled manner. Tests are carried out with a free-flowing grade of lactose and croscarmellose sodium as an example of cohesive powder. Results At feed rates of a few grams per hour, for the investigated materials, the system has at least the same performance as conventional feeders at significantly higher feed rates. Especially at low feed rates, less fluctuations are obvious and accuracy and precision of the micro-feeder are at the same level as for the established feeding technology at rates ten times higher. Conclusion For the two types of investigated materials (free-flowing and cohesive), the micro-feeding system shows similar or better performance than conventional and commercially applied LIW feeders. The technology offers the potential for highly accurate, continuous feeding in the low-dose range.

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Development of a micro dosing system for fine powder using a vibrating capillary. Part 1: The investigation of factors influencing on the dosing performance

Cited by 15 publications

References 16 publications

Innovative Process Strategies in Powder-Based Multi-Material Additive Manufacturing

Innovative Process Strategies in Powder-Based Multi-Material Additive Manufacturing

The Future of Pharmaceutical Manufacturing Sciences

Comparative Study of a Novel Micro-feeder and Loss-in-weight Feeders

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