Development of a molecular K+ probe for colorimetric/fluorescent/photoacoustic detection of K+

Highly K+ Selective Probes with Fluorescence Emission Wavelengths Higher than 500 nm in Water

“…( K d =88 mM, φ f =0.005 (in the presence of 140 mM K + ), λ f =650 nm) [2b] and to the lariat ether fluorescent probe by Tian et al . ( φ f =0.021 (in the presence of 150 mM K + ), λ f =670 nm) [5d] . However, the K + NIR fluorescent probes by Klimant et al .…”

“…Recently, we synthesized easily accessible and highly K + /Na + selective fluorescent probes based on a N ‐(2‐methoxyethoxyphenyl)aza‐18‐crown‐6 lariat ionophore [3a–c] by using Cu(I)‐catalyzed 1,3‐dipolar azide alkyne cycloaddition (CuAAC) reactions [4a,b] . Nowadays, this lariat ionophore is part of a set of highly K + selective indicators [5a–e] …”

Potassium Ion Fluorescence Probes: Structures, Properties and Bioimaging

“…Accordingly, the selection and modification of the ion‐selective receptor is the lynchpin for selectivity. Meanwhile, the excitation and emission spectra of K + probes need to be further extended into longer wavelengths to facilitate in vivo studies and potentially be employed in multi‐mode detection [54] . Moreover, ratiometric measurements of K + [55] are desirable when the ratio of fluorescence intensities at separable wavelengths can provide relatively precise measurements of K + concentration, mitigating potential effects of the fluoroionophore contrast agent spatial concentration and incident light intensity.…”

Targeted contrast agents and activatable probes for photoacoustic imaging of cancer

“…It is worth noting that in addition to the aforementioned Cu probes, a number of groups have developed PA imaging agents for detection of Li + , 212 K + , 213,214 Ca 2+ 215–218 and Zn 2+ . 219,220 Although these have yet to be applied to track metal ions in cancer models, we anticipate this will be an exciting avenue to pursue in future studies.…”