Development of a multi-residue analytical method, based on liquid chromatography–tandem mass spectrometry, for the simultaneous determination of 46 micro-contaminants in aqueous samples

Nödler, Karsten; Licha, Tobias; Bester, Kai; Sauter, Martin

doi:10.1016/j.chroma.2010.08.048

Cited by 187 publications

(106 citation statements)

References 54 publications

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“…In Taiwan coastal waters, the concentrations of diclofenac and ibuprofen were also in the same order of magnitude of those reported herein, though ketoprofen was detected at lower levels, not exceeding 7 ng L − 1 (Fang et al, 2012). Nevertheless, Nödler et al (2010) were not able to detect diclofenac, ibuprofen, naproxen and acetaminophen in the Baltic Sea (German coastal area) (Nödler et al, 2010).…”

Section: Occurrence Of Pharmaceuticals In Portuguese Seawaters: Geogrmentioning

confidence: 64%

“…Several therapeutic groups were studied, including, for example, non-steroidal anti-inflammatory drugs (NSAIDs) Wille et al, 2010), analgesics Nödler et al, 2010), antibiotics (Nebot et al, 2007;Wille et al, 2010), β-blockers Wille et al, 2010), lipid regulators (Fang et al, 2012;Gros et al, 2012) and psychiatric drugs Wille et al, 2010). Diclofenac (Rodriguez-Navas et al, 2013), ibuprofen (Loos et al, 2013b), naproxen , ketoprofen , salicylic acid (Wille et al, 2010), acetaminophen and codeine are among the most de-tected NSAIDs/analgesics in seawaters of the North, Mediterranean and Adriatic Seas and even in the Pacific and Indian Oceans at levels up to few hundred ng L −1 .…”

Section: Introductionmentioning

confidence: 99%

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Assessment of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawaters of North of Portugal: Occurrence and environmental risk

Lolić

Paíga

Santos

et al. 2015

Science of The Total Environment

178

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A B S T R A C TThe occurrence of seven pharmaceuticals and two metabolites belonging to non-steroidal anti-inflammatory drugs and analgesics therapeutic classes was studied in seawaters. A total of 101 samples covering fourteen beaches and five cities were evaluated in order to assess the spatial distribution of pharmaceuticals among north Portuguese coast. Seawaters were selected in order to embrace different bathing water quality (excellent, good and sufficient). Acetaminophen, ketoprofen and the metabolite hydroxyibuprofen were detected in all the seawater samples at maximum concentrations of 584, 89.7 and 287 ng L −1 , respectively. Carboxyibuprofen had the highest seawater concentration (1227 ng L −1 ). The temporal distribution of the selected pharmaceuticals during the bathing season showed that, in general, higher concentrations were detected in August and Septem-ber. The environmental risk posed by the pharmaceuticals detected in seawaters towards different trophic levels (fish, daphnids and algae) was also assessed. Only diclofenac showed hazard quotients above one for fish, representing a potential risk for aquatic organisms. These results were observed in seawaters classified as excellent bathing water. Additional data is needed in order to support the identification and prioritization of risks posed by pharmaceuticals in marine environment.

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Section: Occurrence Of Pharmaceuticals In Portuguese Seawaters: Geogrmentioning

confidence: 64%

Section: Introductionmentioning

confidence: 99%

Assessment of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawaters of North of Portugal: Occurrence and environmental risk

Lolić

Paíga

Santos

et al. 2015

Science of The Total Environment

178

View full text Add to dashboard Cite

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“…The measured concentrations were in the range of 27 to 27,386 ng L −1 confirming the existence of raw sewage discharge. The caffeine contamination was detected globally, in Germany surface waters was measured 101 ng L −1 [8] and in Atibaia River was in the range of 6000 to 32,000 ng L −1 [16].…”

Section: Resultsmentioning

confidence: 99%

Guarapiranga Reservoir—Pharmaceuticals and Historical Urban Occupation in a Water Source

Shihomatsu¹,

Martins²,

Cotrim³

et al. 2017

GEP

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The pharmaceutical compounds were analyzed in 14 sampling sites and pointed out the pollution sources related to raw sewage input and urban drainage discharge. Five medicine compounds, one illicit drug, and its metabolite were the higher measured content using analytical improvements tailored to identify and quantify organic compounds in low water content. The use of SPE cartridges followed by liquid chromatography with tandem mass spectrometry (LC-ESI-MS/MS) points out the Guavirutuba tributary as the primary water pollution source with higher concentrations in 2011 for pharmaceuticals, cocaine, and benzoylecgonine (metabolite) in the range of 6.7 ± 0.9 ng L −1 to 27.386 ± 142 ng L −1. The Jaceguay stream also located in Guarapiranga was the most preserved area and provided analytical values correspondent which lowered contamination content. Such concentrations mean a possible and feasible water restoration target. The most common compounds (above 90% samples) were: caffeine, atenolol, carbamazepine, cocaine, and benzoylecgonine. The integrated risk index for aquatic chemical pollution (IRICAP) confirms the higher contamination near Guavirutuba stream and the lower near the Jaceguay stream. Published results of cocaine and benzoylecgonine content in Guarapiranga basin corroborated with the analytical results.

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“…14 Theobromine was detected at above 100 ng/L (n = 4) in effluents of several WWTPs, 49 and 1-methylxanthine was detected at 61 ng/L in river samples 50 . During the A2O process, removal efficiencies of caffeine derivatives were effective (above 95%) except for xanthine (-5.4%).…”

Section: Application To Wastewater Samplesmentioning

confidence: 99%

Determination of Caffeine and Its Metabolites in Wastewater Treatment Plants Using Solid-Phase Extraction and Liquid Chromatography–Tandem Mass Spectrometry

Echigo

Itoh

2018

ANAL. SCI.

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For caffeine and its seven major metabolites (i.e., theobromine, theophylline, paraxanthine, 1-methylxanthine, 3-methylxanthine, 7-methylxanthine, and xanthine), an optimized analytical method using liquid chromatography-tandem mass spectrometry (LC-MS/MS) for their detection in wastewater samples was developed in this study. Extraction of these compounds (recoveries ranged from 60.3 to 83.2%) was made possible by combining universal polymeric reversedphase cartridge and polymeric strong cation exchange cartridge. This method was applied to the determination of caffeine and its metabolites in the influent and effluent of an anaerobic-anoxic-oxic (A2O) process. In the A2O influent, caffeine and its metabolites (except xanthine) ranged from 1.39 to 5.45 μg/L, and their concentrations in the A2O effluent ranged from 10.2 to 171.3 ng/L. The mass load of caffeine was 14.9 g/day/1000 inhabitants, considering the population served by the target wastewater treatment plant (WWTP). The concentration of caffeine derivatives in wastewater influent is a tool for estimating the population size in the area served by WWTPs.

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Development of a multi-residue analytical method, based on liquid chromatography–tandem mass spectrometry, for the simultaneous determination of 46 micro-contaminants in aqueous samples

Cited by 187 publications

References 54 publications

Assessment of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawaters of North of Portugal: Occurrence and environmental risk

Assessment of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawaters of North of Portugal: Occurrence and environmental risk

Guarapiranga Reservoir—Pharmaceuticals and Historical Urban Occupation in a Water Source

Determination of Caffeine and Its Metabolites in Wastewater Treatment Plants Using Solid-Phase Extraction and Liquid Chromatography–Tandem Mass Spectrometry

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