Development of a natural preservative system using the mixture of chitosan‐<i>Inula helenium</i> L. extract

Seo, Sang Bong; Ryu, Chang-Suk; Ahn, Gwang-Hwan; Kim, H.-B.; Jo, Byoung-Kee; Kim, S.-H.; Lee, J.-D.; Kajiuchi, Toshio

doi:10.1046/j.1467-2494.2002.00139.x

Cited by 21 publications

(13 citation statements)

References 15 publications

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“…The results of this work are also consistent with the studies of Seo et al (2002). These authors developed a preservative system that consisted of a mixture of chitosan and Inula helenium L extract, whose results presented excellent antimicrobial effect in cosmetic and transdermal formulations in the challenge test against strains of A. niger, C. albicans, E. coli, P. aeruginosa and S. aureus.…”

Section: Evaluation Of a Preservative System In A Gel Containing Hydrsupporting

confidence: 88%

Evaluation of a preservative system in a gel containing hydroalcoholic extract of Schinus terebinthifolius

Moura¹,

Raffin²,

Santos³

2011

Rev. bras. farmacogn.

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Currently, microbial contamination is one of the major problems faced by the phytomedicine industry with respect to the quality of the raw materials. The objective of this study was to evaluate the effectiveness of a preservative system in a formulation with hydrogel containing hydroalcoholic extract of Schinus terebinthifolius Raddi, Anacardiaceae ("aroeira" or "Brazilian Peppertree"), through the challenge test. The extracts were prepared by maceration at a ratio of 1:10 plant/solvent in 40% alcohol. Gel samples were artificially contaminated with separate inocula of Aspergillus niger, Candida albicans, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa and the number of viable microorganisms determined in triplicate by the "pour plate" method for counting colonies at 0, 24 and 48h, 7, 14, 21 and 28 days. The addition of the preservatives (methyl and propylparaben) in the "aroeira" gel proved to be effective against the studied species when the samples were evaluated using the challenge test. According to the criterion A of the European Pharmacopoeia, it was verified that the hydrogel product showed good conservation in a 28 days period.

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Section: Evaluation Of a Preservative System In A Gel Containing Hydrsupporting

confidence: 88%

Evaluation of a preservative system in a gel containing hydroalcoholic extract of Schinus terebinthifolius

Moura¹,

Raffin²,

Santos³

2011

Rev. bras. farmacogn.

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“…In both examined emulsions, extract was effective against P. aeruginosa, B. cepacia, S. aureus and E. coli, presenting a lethal effect at 2 days after inoculation and maintained for 28 days of incubation. In other studies, the preservative efficacy of chitosan and Inula helenium was evaluated [29]. The mixture of chitosan powder and Inula helenium extract powder in the ratio 1:3 was incorporated at concentrations of 5-10 % (w/w) in O/W emulsion formulas and tonic lotion.…”

Section: Discussionmentioning

confidence: 99%

Essential Oils and Herbal Extracts as Antimicrobial Agents in Cosmetic Emulsion

et al. 2012

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The cosmetic industry adapts to the needs of consumers seeking to limit the use of preservatives and develop of preservative-free or self-preserving cosmetics, where preservatives are replaced by raw materials of plant origin. The aim of study was a comparison of the antimicrobial activity of extracts (Matricaria chamomilla, Aloe vera, Calendula officinalis) and essential oils (Lavandulla officinallis, Melaleuca alternifolia, Cinnamomum zeylanicum) with methylparaben. Extracts (2.5 %), essential oils (2.5 %) and methylparaben (0.4 %) were tested against Pseudomonas aeruginosa ATCC 27853, Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 29213, Candida albicans ATCC 14053. Essentials oils showed higher inhibitory activity against tested microorganism strain than extracts and methylparaben. Depending on tested microorganism strain, all tested extracts and essential oils show antimicrobial activity 0.8-1.7 and 1-3.5 times stronger than methylparaben, respectively. This shows that tested extracts and essential oils could replace use of methylparaben, at the same time giving a guarantee of microbiological purity of the cosmetic under its use and storage.

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“…In others studies, Seo et al (2002) developed a preservative system that consisted of a mixture of chitosan and Inula helenium extract at 10% (w/w). These results presented an excellent antimicrobial effect in cosmetic formulations against strains of A. niger, C. albicans, E. coli, P. aeruginosa and S. aureus.…”

Section: Discussionmentioning

confidence: 99%

“…Efforts have been directed to the development of natural preservatives with antimicrobial properties to reduce or even replace the synthetic preservative. Among these natural compounds, plant derivatives such as extracts and essential oils (Maccioni et al 2002;Seo et al 2002;Nostro et al 2004;Ostrosky et al 2011) are widely used because of their antimicrobial activities and, therefore, have been proposed as alternative synthetic preservative agents.…”

Section: Introductionmentioning

confidence: 99%

Development of Natural Preservative from Silene vulgaris Extract in Topical Formulation under a Challenge Test and its Stability Stud

2017

J App Pharma Sci

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The development of natural preservatives provides a way of substituting or decreasing the amount of synthetic preservatives normally used in pharmaceutical and cosmetic products. The purpose of this research was to evaluate the Silene vulgaris extract efficiency as a natural preservative in topical cream formulation. The antimicrobial activity of S. vulgaris extract was assayed for determination of the minimum inhibitory concentration. The in-vitro stability was studied for the cream formulation stored at different temperatures 4°C, 25°C and 37°C. However the effectiveness of antimicrobial effect of extracts at concentrations (2-20%) in topical cream was assayed by using a microbial challenge test. This test was performed following the standard procedure proposed by The European Pharmacopoeia, using reference strains: Staphylococcus aureus ATCC 29213, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Candida albicans ATCC 10231 and Aspergillus brasiliensis ATCC 16404. The results demonstrated that S. vulgaris extract at10% and 20% (w/w) reduced the bacteria and fungi inocula, according to the criterion A of the European Pharmacopoeia, with a significant conservation during a period of 28 days compared to phenoxyethanol as a synthetic preservative. Our study indicate that under the tests conditions, Silene vulgaris extract has antimicrobial activity and could be considered as an alternative preservative for cosmetic formulations.

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Development of a natural preservative system using the mixture of chitosan‐Inula helenium L. extract

Cited by 21 publications

References 15 publications

Evaluation of a preservative system in a gel containing hydroalcoholic extract of Schinus terebinthifolius

Evaluation of a preservative system in a gel containing hydroalcoholic extract of Schinus terebinthifolius

Essential Oils and Herbal Extracts as Antimicrobial Agents in Cosmetic Emulsion

Development of Natural Preservative from Silene vulgaris Extract in Topical Formulation under a Challenge Test and its Stability Stud

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