Development of a new 3D bioprinted antibiotic delivery system based on a cross-linked gelatin–alginate hydrogel

Mirek, A.; Belaid, Habib; Barranger, Fanny; Grzeczkowicz, Marcin; Bouden, Yasmine; Cavaillès, Vincent; Lewińska, Dorota; Bechelany, Mikhaël

doi:10.1039/d2tb01268e

Cited by 17 publications

(7 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This property was used to design the physically self-healing hydrogels via the self-assembling mechanism of monomers in an aqueous medium. A popular technique for creating hydrophobic bond-based self-healing hydrogels is micellar polymerization [ 50 ]. At a temperature of 25 °C, a hydrogel sample was cut into two parts, and then 3 mL DI water was sprayed to wet the surfaces so that the cutting surfaces could stick together easily.…”

Section: Resultsmentioning

confidence: 99%

Highly Conductive and Reusable Cellulose Hydrogels for Supercapacitor Applications

et al. 2023

View full text Add to dashboard Cite

We report Na-Alginate-based hydrogels with high ionic conductivity and water content fabrication using poly (3,4-ethylene dioxythiophene) (PEDOT): poly (4-styrene sulfonic acid) (PSS) and a hydrogel matrix based on dimethyl sulfoxide (DMSO). DMSO was incorporated within the PEDOT:PSS hydrogel. A hydrogel with higher conductivity was created through the in-situ synthesis of intra-Na-Alginate, which was then improved upon by H2SO4 treatment. Field emission scanning electron microscopy (FESEM) was used to examine the surface morphology of the pure and synthetic hydrogel. Structural analysis was performed using Fourier-transform infrared spectroscopy (FTIR). Thermogravimetric analysis (TGA), which examines thermal properties, was also used. A specific capacitance of 312 F/g at 80 mV/s (energy density of 40.58 W/kg at a power density of 402.20 W/kg) at 100 DC mA/g was achieved by the symmetric Na-Alginate/PEDOT:PSS based flexible supercapacitor. The electrolyte achieved a higher ionic conductivity of 9.82 × 10−2 and 7.6 × 10−2 Scm−1 of Na-Alginate and a composite of Na-Alginate/PEDOT:PSS at 25 °C. Furthermore, the supercapacitor Na-Alginate/PEDOT:PSS//AC had excellent electrochemical stability by showing a capacity retention of 92.5% after 3000 continuous charge–discharge cycles at 10 mA current density. The Na- Alginate/PEDOT:PSS hydrogel displayed excellent flexibility and self-healing after re-contacting the two cut hydrogel samples of electrolyte for 90 min because of the dynamic cross-linking network efficiently dissipated energy. The illumination of a light-emitting diode (LED) verified the hydrogel’s capacity for self-healing.

show abstract

Section: Resultsmentioning

confidence: 99%

Highly Conductive and Reusable Cellulose Hydrogels for Supercapacitor Applications

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Its printing temperature (37 • C) renders it compatible with living cells and heat-sensitive substances, including drugs. While it is solid at room temperature, the solidification process can be accelerated by reducing the temperature of the collector [46]. A combination of gelatin-based hydrogel with gelatin methacryloyl can undergo photo-crosslinking in the presence of a water-soluble photo-initiator under blue-light irradiation [47].…”

Section: Hydrogels Used With Calcium Phosphates In 3d Bioprintingmentioning

confidence: 99%

Calcium Phosphate Biomaterials for 3D Bioprinting in Bone Tissue Engineering

Tolmacheva,

Bhattacharyya,

Noh

2024

Biomimetics

View full text Add to dashboard Cite

Three-dimensional bioprinting is a promising technology for bone tissue engineering. However, most hydrogel bioinks lack the mechanical and post-printing fidelity properties suitable for such hard tissue regeneration. To overcome these weak properties, calcium phosphates can be employed in a bioink to compensate for the lack of certain characteristics. Further, the extracellular matrix of natural bone contains this mineral, resulting in its structural robustness. Thus, calcium phosphates are necessary components of bioink for bone tissue engineering. This review paper examines different recently explored calcium phosphates, as a component of potential bioinks, for the biological, mechanical and structural properties required of 3D bioprinted scaffolds, exploring their distinctive properties that render them favorable biomaterials for bone tissue engineering. The discussion encompasses recent applications and adaptations of 3D-printed scaffolds built with calcium phosphates, delving into the scientific reasons behind the prevalence of certain types of calcium phosphates over others. Additionally, this paper elucidates their interactions with polymer hydrogels for 3D bioprinting applications. Overall, the current status of calcium phosphate/hydrogel bioinks for 3D bioprinting in bone tissue engineering has been investigated.

show abstract

“…13,14 The gelatin molecule consists mainly of a repeating sequence of the glycine-proline-hydroxyproline triplet, 15 and it has the advantage of strong gelation ability that makes it an important candidate for biomedical materials and tissue engineering. 16,17 However, gelatin is unstable through the network structure formed by hydrogen bonding, lacks sufficient mechanical strength, and dissolves relatively quickly at higher temperatures and a sol-gel transition occurs. 18 When they are used as drug delivery carriers and immersed in simulated human body fluids, leakage of the loaded drug occurs.…”

Section: Introductionmentioning

confidence: 99%

The fabrication of stretchable dual network P(HEMA-AM)/gelatin hydrogels as potential delivery carriers

Xu,

Liu,

Wang

et al. 2024

New J. Chem.

View full text Add to dashboard Cite

show abstract

Development of a new 3D bioprinted antibiotic delivery system based on a cross-linked gelatin–alginate hydrogel

Abstract: 3D bioprinting uses bioink deposited directly on a collector to create any previously designed 3D model. One of the most common and the easiest to operate bioinks is gelatin-alginate hydrogel....

Cited by 17 publications

References 43 publications

Highly Conductive and Reusable Cellulose Hydrogels for Supercapacitor Applications

Highly Conductive and Reusable Cellulose Hydrogels for Supercapacitor Applications

Calcium Phosphate Biomaterials for 3D Bioprinting in Bone Tissue Engineering

The fabrication of stretchable dual network P(HEMA-AM)/gelatin hydrogels as potential delivery carriers

Contact Info

Product

Resources

About