Development of a New Coated Platinum Selective Electrode for Moxifloxacin Determination

Abstract

the construction of a new moxifloxacin hydrochloride (MOX) coated platinum selective electrode based on moxifloxacin-tetraphenylborate (MOX-TPB) as electroactive material is described. Plasticized polymeric membranes with a composition of PVC:o-NPPE:MOX-TPB:KTCPB in the percentage ratio of 30:66:2:2 (%, w:w:w) was selected. The sensor displayed rapid, stable and near-Nernstian response, 57.6 ± 0.6 mV.decade −1 , over the concentration range of 2.0 × 10 -6 to 1.0 × 10 -2 mol.L -1 . The pH does not affect the performances of the proposed electrode within the pH range 3.0-5.5. The electrode is proved to have a good selectivity for moxifloxacin hydrochloride over some inorganic and organic compounds. The constructed electrode was proved to be successful for the potentiometric titration of moxifloxacin cation with tetraphenylborate solution in raw material and in reconstituted powders containing MOX. The results were validated by comparison with a capillary electrophoresis method.

Moxifloxacin Hydrochloride Electrochemical Detection at Gold Nanoparticles Modified Screen-Printed Electrode

“…The limit of detection (LOD = 3 σ/m) and limit of quantification (LOQ = 10 σ/m), where, σ is the standard deviation and m is the calibration plot slope were obtained as 11.6 µM and 38.6 µM, respectively. Comparing the obtained data for Moxi determination by GNMSPE against others analytical or methods [7,60,61] or electrochemical techniques [12][13][14] shows acceptable performance of the proposed novel sensor, offering opportunities for on-site analyses thanks to the possible mass production of low-cost screen-printed electrodes and the suggested electrochemical sensor for Moxi detection also compared with others [17,[62][63][64][65][66][67] in terms of detection limits, as shown in Table 1.…”