Development of a new method for small bowel transit study

Hung, Guang-Uei; Tsai, C H; Lin, Wan‐Yu

doi:10.1007/bf03027373

Cited by 13 publications

(8 citation statements)

References 26 publications

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“…Though the measurement of orocaecal transit times is rarely performed in clinical routine, a reliable assessment of the intestinal transit is desirable, particularly in pharmacological trials. Emerging technologies of enteral drug delivery systems require an exact definition of the delivery site within the intestine to warrant pharmacokinetic and dynamic actions that have been predicted in ex vivo models [12,13,17–20]. The therapeutic consequences of intestinal transit testing for routine purposes still remains to be determined.…”

Section: Discussionmentioning

confidence: 99%

The inulin hydrogen breath test accurately reflects orocaecal transit time

Schneider

Jepp

Murczynski

et al. 2007

Eur J Clin Investigation

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Section: Discussionmentioning

confidence: 99%

The inulin hydrogen breath test accurately reflects orocaecal transit time

Schneider

Jepp

Murczynski

et al. 2007

Eur J Clin Investigation

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“…The small intestine can be divided into three segments: duodenum, jejunum, and ileum [ 102 ]. The transit time of the small intestine was found to be between 30 min and 4.5 h [ 103 ]. Once the gastric content enters the duodenum, it is neutralized by bicarbonate derived from the pancreas, liver, and duodenal mucosa, causing pH fluctuations [ 104 ].…”

Section: Akkermansia Muciniphila Along the Humamentioning

confidence: 99%

Akkermansia muciniphila in the Human Gastrointestinal Tract: When, Where, and How?

et al. 2018

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Akkermansia muciniphila is a mucin-degrading bacterium of the phylum Verrucomicrobia. Its abundance in the human intestinal tract is inversely correlated to several disease states. A. muciniphila resides in the mucus layer of the large intestine, where it is involved in maintaining intestinal integrity. We explore the presence of Akkermansia-like spp. based on its 16S rRNA sequence and metagenomic signatures in the human body so as to understand its colonization pattern in time and space. A. muciniphila signatures were detected in colonic samples as early as a few weeks after birth and likely could be maintained throughout life. The sites where Akkermansia-like sequences (including Verrucomicrobia phylum and/or Akkermansia spp. sequences found in the literature) were detected apart from the colon included human milk, the oral cavity, the pancreas, the biliary system, the small intestine, and the appendix. The function of Akkermansia-like spp. in these sites may differ from that in the mucosal layer of the colon. A. muciniphila present in the appendix or in human milk could play a role in the re-colonization of the colon or breast-fed infants, respectively. In conclusion, even though A. muciniphila is most abundantly present in the colon, the presence of Akkermansia-like spp. along the digestive tract indicates that this bacterium might have more functions than those currently known.

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“…Radiopaque markers are mainly suitable for the study of colonic and whole gut transit. Hydrogen breath test measures orocecal transit time rather than the pure small intestinal transit time, and its results may be misinterpreted in the presence of SIBO ( 1 , 3 ).…”

Section: Introductionmentioning

confidence: 99%

Video Capsule Endoscopy: A Tool for the Assessment of Small Bowel Transit Time

et al. 2016

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PurposeVideo capsule endoscopy (VCE) is a procedure that uses a wireless camera to take pictures of the gastrointestinal (GI) tract. A wireless motility capsule (WMC) of a similar size has been developed, which measures pH, pressure, and temperature and can be used to assess regional and total GI transit times. VCE could also potentially be used as a tool for measuring small bowel transit time (SBTT).MethodsThis study was designed to obtain SBTT from VCE and compare it with historical data generated by WMC. Gastric transit time (GTT) was also measured. Patients were included if the indication for VCE was either iron deficiency anemia (IDA) or overt obscure GI bleed (OOGIB), and they did not have any known motility disorder. Results from VCE were also compared in diabetic vs. non-diabetic patients.ResultsThere were a total of 147 VCE studies performed, including 42 for OOGIB and 105 for IDA. Median GTT and SBTT were 0.3 and 3.6 h, respectively. The overall median GTT and SBTT were 0.3 and 3.6 h, respectively, in the IDA group compared with 0.3 and 3.4 h in the OOGIB group. When compared with WMC, the GTT and SBTT were significantly faster in both groups (GTT: 3.6 h and SBTT: 4.6 h). The median GTT and SBTT were not significantly different in diabetics vs. non-diabetics [GTT: 17.5 vs. 18.0 min (P = 0.86) and SBTT: 3.9 h (237 min) vs. 3.8 h (230 min), respectively (P = 0.90)].ConclusionSBTT as measured using VCE is not significantly different in OOGIB compared with IDA. Both GTT and SBTT are significantly faster as assessed by VCE, which is initiated in the fasting state, compared with WMC measurement, which is initiated after a standard meal. In summary, VCE could potentially be used for measuring SBTT in the fasting state.

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Development of a new method for small bowel transit study

Abstract: We consider activated charcoal labeled with Tc-99m pertechnetate using an enteric capsule as the carrier to be a potential radioactive marker for small bowel transit study.

Cited by 13 publications

References 26 publications

The inulin hydrogen breath test accurately reflects orocaecal transit time

The inulin hydrogen breath test accurately reflects orocaecal transit time

Akkermansia muciniphila in the Human Gastrointestinal Tract: When, Where, and How?

Video Capsule Endoscopy: A Tool for the Assessment of Small Bowel Transit Time

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