Development of a new model of subcoronary valvular aortic stenosis to create ventricular hypertrophy

Roper, Keith; Levitsky, Sidney; Vorachek, Mary A.; Wright, Robin M.; Eckner, Friedrich A. O.; Feinberg, Harold

doi:10.1016/0022-4804(78)90096-3

Cited by 11 publications

(1 citation statement)

References 14 publications

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“…These findings indicate that experimentally induced aortic stenosis produces functional and metabolic changes at variance with clinical observations of patients presenting with aortic valvular stenosis. Roper et al (1978) reported an experimental model of sub-coronary aortic stenosis which was induced by placating the non-coronary sinus of Valsalva. Using a similar approach, we created sub-coronary aortic stenosis in puppies.…”

Section: Discussionmentioning

confidence: 99%

Biochemical and hemodynamic changes in the hypertrophied dog heart subjected to chronic protein-calorie malnutrition.

Tabayashi

Iguchi

Arai

et al. 1987

Tohoku J. Exp. Med.

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Biochemical and hemodynamic changes were assessed in 13 dogs subjected to sub-coronary valvular aortic stenosis and chronic protein-calorie malnutrition (PCM). Red blood cell, hemoglobin, serum albumin, free fatty acids, blood glucose, cholinesterase and blood amino acid levels were measured. The dynamic geometry of the left ventricle (LV) was assessed with chronically implanted sonomicrometric piezoelectric crystals. Cardiac function was evaluated by mean velocity of circumferential fiber shortening (mean VcF) and the relationship between LV end-systolic pressure (LVESP) or LV wall stress (LVWst) and LV end-systolic diameter (LVESD). The following results were obtained : 1) A decrease in body weight and increases in free fatty acids and 3-Methylhistidine were observed following long-term PCM. 2) Mean VcF was not depressed in dogs subjected to PCM. 3) The relationship between LVESP or LVWst and LVESD shipted downward and to the right after PCM, indicating reduced myocardial contractility. These findings suggest that the left ventricle in hypertrophied dog hearts subjected to PCM retains normal pump function, despite a low state in the myocardium.protein-calorie malnutrition ; sub-coronary aortic stenosis ; free acid ; 3-Methylhistidine ; myocardial contractility

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Section: Discussionmentioning

confidence: 99%