Development of a New Pulsatile Extracorporeal Life Support Device Incorporating a Dual Pulsatile Blood Pump

Choi, Suji; Nam, Kyoung Won; Chung, Jin Wook; Lee, J. C.; Hwang, Chang Mo; Won, Yong Sung; Sun, Kyung; Min, Byoung Goo

doi:10.1177/039139880602900607

Cited by 5 publications

(9 citation statements)

References 20 publications

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“…Because its weight is only 35 kg and is powered by an internal rechargeable lithium ion battery, it can be a portable blood pump. Moreover, the automatic priming function and the intelligent flow rates control algorithm enable the machine to be prepared quickly in emergency cases (5). On the contrary, the AK90 has a height, width, and thickness of 1270, 350, and 420 mm, respectively.…”

Section: Discussionmentioning

confidence: 99%

Comparison of a Pulsatile Blood Pump and a Peristaltic Roller Pump During Hemoperfusion Treatment in a Canine Model of Paraquat Poisoning

et al. 2008

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This study examined the treatment efficacy and the damage to the blood during hemoperfusion for treating paraquat poisoning using two blood pump mechanisms. Paraquat-poisoned animal models were prepared. A conventional hemodialysis machine, AK90, with a peristaltic roller pump and a cardiopulmonary support system, T-PLS, with a pulsatile blood pump were used during the animal experiments. A total of 12 dogs were treated with hemoperfusion using a charcoal column. Six dogs were treated with hemoperfusion and T-PLS, and the other six were treated with AK90. A paraquat dose of 30 mg/kg was administrated by an intravenous injection. Both pumps maintained blood flow rates of 125 mL/min measured by an ultrasonic flowmeter. For anticoagulation, heparin was administrated by an initial bolus (250 IU/kg) and a continuous injection (100 IU/kg/h). During the experiments, T-PLS and AK90 showed a similar toxin removal efficacy. Both devices decreased the plasma paraquat concentration to 10% of the initial dose within 4-h hemoperfusion. The two pumps showed similar hemolysis properties with acceptable levels. Although T-PLS was developed as a cardiopulmonary bypass system, it can also be used as a hemoperfusion treatment device.

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Section: Discussionmentioning

confidence: 99%

Comparison of a Pulsatile Blood Pump and a Peristaltic Roller Pump During Hemoperfusion Treatment in a Canine Model of Paraquat Poisoning

et al. 2008

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“…The T-PLS is composed of two PU tubes, four valves, and a reciprocating actuator that runs between the two tubes (1). When the actuator presses on a PU tube, the blood in the tube flows out through the outlet valve.…”

Section: T-pls Structurementioning

confidence: 99%

“…The prevention of vein collapse is essential to maintaining the proper blood inflow and reliable operation of pulsatile extracorporeal life support (ECLS) (1)(2)(3). Blood inflow is determined from the blood flow resistance along the inlet path and the blood pressure difference between the vein and the ECLS inlet port.…”

mentioning

confidence: 99%

“…Blood inflow is determined from the blood flow resistance along the inlet path and the blood pressure difference between the vein and the ECLS inlet port. Because of the high flow resistance of the long and narrow catheter and cannula, the prepump pressure can fall to a very low level, for example, below -180 mm Hg (1,(4)(5)(6). However, such extremely low prepump pressures cause the venous blood pressure near the tip of the inlet catheter to decrease to a level that poses a risk of vein collapse (7)(8)(9).…”

mentioning

confidence: 99%

“…The recently developed pulsatile ECLS (T-PLS, Newheartbio Co. Ltd., Seoul, Korea) supplies pulsatile blood flow via a mechanical actuator and a polyurethane (PU) tube (1,10,11). The volume change of the PU tube in a T-PLS can be measured indirectly from the actuator movement data during the period in the device pulsation cycle when the consumed current is high.…”

mentioning

confidence: 99%

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Venous Pressure Regulation During Pulsatile Extracorporeal Life Support

Choi

Nam

2008

Artificial Organs

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During the use of pulsatile extracorporeal life support (pulsatile-ECLS), the patient's venous pressure near the inlet venous catheter tip must be monitored to maintain sufficient blood flow and to prevent vein collapse. However, direct measurement of the venous pressure and the estimate of suction using measured blood inflow and prepump pressure are not practical because of setup difficulties during emergency treatments and in cardiovascular operations. In this article, we describe a new method for estimating the venous pressure that can be implemented in the controller of the pulsatile-ECLS system, the T-PLS. It uses real-time measurement of the electric current and actuator motion. The current waveform of the T-PLS is used to determine the outflow amount and the volume remaining in the pulsatile pumps. Previously measured values of the pulsatile-ECLS compliance and the hemodynamic resistance along the inflow path are used to evaluate venous pressure with estimated blood flow. Estimated prepump pressure, inflow, and venous pressure were compared to the measured data in a series of in vitro experiments. The estimated venous pressure was used to avoid vein collapse and to increase the reliability in animal experiments.

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Preclinical Studies on Pulsatile Veno-Arterial Extracorporeal Membrane Oxygenation: A Systematic Review

Kanagarajan

Heinsar

Gandini³

et al. 2023

ASAIO Journal

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Refractory cardiogenic shock is increasingly being treated with veno-arterial extracorporeal membrane oxygenation (V-A ECMO), without definitive proof of improved clinical outcomes. Recently, pulsatile V-A ECMO has been developed to address some of the shortcomings of contemporary continuous-flow devices. To describe current pulsatile V-A ECMO studies, we conducted a systematic review of all preclinical studies in this area. We adhered to PRISMA and Cochrane guidelines for conducting systematic reviews. The literature search was performed using Science Direct, Web of Science, Scopus, and PubMed databases. All preclinical experimental studies investigating pulsatile V-A ECMO and published before July 26, 2022 were included. We extracted data relating to the 1) ECMO circuits, 2) pulsatile blood flow conditions, 3) key study outcomes, and 4) other relevant experimental conditions. Forty-five manuscripts of pulsatile V-A ECMO were included in this review detailing 26 in vitro, two in silico, and 17 in vivo experiments. Hemodynamic energy production was the most investigated outcome (69%). A total of 53% of studies used a diagonal pump to achieve pulsatile flow. Most literature on pulsatile V-A ECMO focuses on hemodynamic energy production, whereas its potential clinical effects such as favorable heart and brain function, end-organ microcirculation, and decreased inflammation remain inconclusive and limited.

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Development of a New Pulsatile Extracorporeal Life Support Device Incorporating a Dual Pulsatile Blood Pump

Cited by 5 publications

References 20 publications

Comparison of a Pulsatile Blood Pump and a Peristaltic Roller Pump During Hemoperfusion Treatment in a Canine Model of Paraquat Poisoning

Comparison of a Pulsatile Blood Pump and a Peristaltic Roller Pump During Hemoperfusion Treatment in a Canine Model of Paraquat Poisoning

Venous Pressure Regulation During Pulsatile Extracorporeal Life Support

Preclinical Studies on Pulsatile Veno-Arterial Extracorporeal Membrane Oxygenation: A Systematic Review

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