Development of a noninvasive HIFU treatment for breast adenocarcinomas using a toroidal transducer based on preliminary attenuation measurements

Sanchez, Marine; Barrère, Victor; Treilleux, Isabelle; Chopin, Nicolás; Melodelima, David

doi:10.1016/j.ultras.2021.106459

Cited by 11 publications

(4 citation statements)

References 54 publications

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“…Several methods have been developed to calculate the attenuation of biological tissues 17,18 . Here, we used the spectral difference method, which involves the comparison of two backscattered RF signals acquired with the focal zone at depths z 1 and z 2 (

\Delta z = z_2-z_1 &gt; 0

) inside the sample.…”

Section: Methodsmentioning

confidence: 99%

“…Several methods have been developed to calculate the attenuation of biological tissues. 17,18 Here, we used the spectral difference method, which involves the comparison of two backscattered RF signals acquired with the focal zone at depths z 1 and z 2 (Δz = z 2 − z 1 > 0) inside the sample. P meas (z 1 , f ) and P meas (z 2 , f ) are the power spectra of the RF signals windowed around the focal zone (window width: 30𝜆, with 𝜆 the wavelength at central frequency).…”

Section: Attenuationmentioning

confidence: 99%

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Quantitative ultrasound techniques for assessing thermal ablation: Measurement of the backscatter coefficient from ex vivo human liver

Rohfritsch,

Franceschini,

Dupré

et al. 2023

Medical Physics

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BackgroundUnderstanding the changes occurring in biological tissue during thermal ablation is at the heart of many current challenges in both therapy and medical imaging research.PurposeThe objective of this work is to quantitatively interpret the scattering response of human liver samples, before and after thermal ablation. We report acoustic measurements performed involving n = 21 human liver samples. Thermal ablation is achieved at temperatures between 45 and 80°C and quantification of the irreversible changes in acoustic attenuation and Backscattering Coefficient (BSC) is reported, with a particular attention to the latter.MethodsBoth attenuation coefficient and BSCs were measured in the frequency range from 10 to 52 MHz. Scans were performed before heating and after cooling down. Attenuation coefficients were calculated using spectral difference method and BSC estimated using the reference phantom method.ResultsStrong increases of attenuation coefficients and BSCs with heating temperature were observed. Quantitative ultrasonic parameters obtained with the polydisperse structure factor model (poly‐SFM)are compared to histological observations and seen to be close to hepatocyte mean diameter (HMD).ConclusionsThe results presented in this study provide a description of the impact of thermal ablation in human liver tissue on acoustic attenuation and the BSC. For the first time, quantitative agreement between the Effective Scatterer Diameter (ESD) estimated from BSC and HMD was shown, highlighting the important role of cellular network in the scattering response of the medium. This core result is an important step toward the determination of the nature of scattering sources in biological tissues.

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\Delta z = z_2-z_1 &gt; 0

) inside the sample.…”

Section: Methodsmentioning

confidence: 99%

Section: Attenuationmentioning

confidence: 99%

Quantitative ultrasound techniques for assessing thermal ablation: Measurement of the backscatter coefficient from ex vivo human liver

Rohfritsch,

Franceschini,

Dupré

et al. 2023

Medical Physics

View full text Add to dashboard Cite

show abstract

“…Moreover, an overlapping area was created between this focal ring and the transducer. This overlapping area increases the size of the lesion that could be created [ 37 ]. An ablation rate of 10.5 cc/min [ 18 ] could be performed without resorting to mechanical scanning, even in highly perfused organs such as the liver [ 20 ].…”

Section: Methodsmentioning

confidence: 99%

Intraoperative HIFU Ablation of the Pancreas Using a Toroidal Transducer in a Porcine Model. The First Step towards a Clinical Treatment of Locally Advanced Pancreatic Cancer

Cilleros

Dupré

Chen

et al. 2021

Cancers

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Apart from palliative chemotherapy, no other therapy has been proven effective for the treatment of locally advanced pancreatic tumors. In this study, an intraoperative high-intensity focused ultrasound (HIFU) device was tested in vivo to demonstrate the feasibility of treating the pancreatic parenchyma and tissues surrounding the superior mesenteric vessels prior to clinical translation of this technique. Twenty pigs were included and treated using a HIFU device equipped with a toroidal transducer and an integrated ultrasound imaging probe. Treatments were performed with energy escalation (from 30 kJ to 52 kJ). All treatments resulted in visible (macroscopically and in ultrasound images) homogeneous thermal damage, which was confirmed by histology. The dimensions of thermal lesions measured in ultrasound images and those measured macroscopically were correlated (r = 0.82, p < 0.05). No arterial spasms or occlusion were observed at the lowest energy setting. Temporary spasm of the peripancreatic artery was observed when using an energy setting greater than 30 kJ. The possibility of treating the pancreas and tissues around mesenteric vessels without vascular thrombosis holds great promise for the treatment of locally advanced pancreatic cancers. If clinically successful, chemotherapy followed by HIFU treatment could rapidly become a novel treatment option for locally advanced pancreatic cancer.

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“…High-intensity focused ultrasound (HIFU) technology is a non-invasive surgical technique that uses ultrasound to treat skin and cancers [1]. For HIFU applications, the driver is preferred to be located near the transducer.…”

Section: Introductionmentioning

confidence: 99%

Power Efficiency Characterization with Various Gate Oxide Thicknesses in Class DE Amplifiers for HIFU Applications

2022

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Skin and cancer cell treatments using high-intensity focused ultrasound (HIFU) have garnered considerable attention as a technology with fewer side effects. Hence, various schemes have been developed to operate ultrasound transducers with high efficiencies. Class DE power amplifiers operate in zero-voltage switching (ZVS) and zero-derivative switching (ZDS); therefore, high-efficiency operation is possible. However, during the CMOS process, a difference in efficiency arises depending on the gate oxide process, which has not yet been analyzed. In high-power devices, a thick oxide layer is primarily used to prevent breakdown. However, this can lead to a decrease in power efficiency. This study analyzes the overall power consumption for each oxide layer thickness during the AMS H35 CMOS process and compares its efficiency. The results confirm that an output power of approximately 1.8 W and a power efficiency of 94% can be obtained with just a relatively thin gate oxide thickness of approximately 10 nm. Furthermore, an additional power efficiency of approximately 3% can be obtained by reducing only the gate oxide thickness.

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Development of a noninvasive HIFU treatment for breast adenocarcinomas using a toroidal transducer based on preliminary attenuation measurements

Cited by 11 publications

References 54 publications

Quantitative ultrasound techniques for assessing thermal ablation: Measurement of the backscatter coefficient from ex vivo human liver

Quantitative ultrasound techniques for assessing thermal ablation: Measurement of the backscatter coefficient from ex vivo human liver

Intraoperative HIFU Ablation of the Pancreas Using a Toroidal Transducer in a Porcine Model. The First Step towards a Clinical Treatment of Locally Advanced Pancreatic Cancer

Power Efficiency Characterization with Various Gate Oxide Thicknesses in Class DE Amplifiers for HIFU Applications

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