Development of a novel direct dental pulp-capping material using 4-META/MMA-TBB resin with nano hydroxyapatite

Yoshida, Shinichiro; Sugii, Hideki; Itoyama, Tomohiro; Kadowaki, Masataka; Hasegawa, Daigaku; Tomokiyo, Atsushi; Ipposhi, Keita; Yamashita, Kozue; Maeda, Hidefumi

doi:10.1016/j.msec.2021.112426

Cited by 15 publications

(19 citation statements)

References 49 publications

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“…Regarding the elemental analysis, CH and ESDHA showed a similar pattern with sharp peaks in Ca, oxygen (O) and carbon (C) elements, which are HA's main components [30]. In the MTA spectrum, in addition to Ca, O and C elements, a Silicon (Si) peak was also detected due to the calcium silicate ingredient of the material, which is indicative of calcium silicate hydrate [31].…”

Section: Discussionmentioning

confidence: 99%

Assessment of the biointeractivity of a novel vital pulp therapy agent derived from eggshell biowaste: An in vitro study

Aksoy,

Karadaş Bakirhan,

Yücel

et al. 2023

Aust Endodontic J

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This study aimed to assess the calcium (Ca2+) and hydroxyl (OH−) ion‐releasing ability, namely the biointeractivity of eggshell‐derived hydroxyapatite (ESDHA) in comparison with mineral trioxide aggregate (MTA) and calcium hydroxide (CH). ESDHA, MTA and CH samples (n = 10; 8 × 1.6 mm) were immersed in 10 mL of deionised water (37°C, pH 6.8). Ca2+ and OH− ion releases were detected in 1, 7 and 21 days. Scanning electron microscopy and Fourier transform infrared spectroscopy analyses were also conducted. IBM SPSS 20.0 was used for statistical analyses. The cumulative Ca2+ ions (56.22 ± 11.28 ppm) were detected as most significant in ESDHA (day 21; p < 0.05). The OH− ion values of the ESDHA group were statistically higher than MTA and CH (days 1 and 7; p < 0.05). ESDHA and CH showed a similar pattern with sharp peaks in Ca2+, oxygen and carbon elements. ESDHA being a sustainable material with a high ion‐releasing ability may be a preferable alternative to the commercial vital pulp therapy agents.

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Section: Discussionmentioning

confidence: 99%

Assessment of the biointeractivity of a novel vital pulp therapy agent derived from eggshell biowaste: An in vitro study

Aksoy,

Karadaş Bakirhan,

Yücel

et al. 2023

Aust Endodontic J

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“…Micro-nano materials with regenerative dentin properties have also been developed for dental pulp capping [ 43 ]. Moreover, some studies suggested that nano-hydroxyapatite promotes dense reparative dentin formation, produces complete dentinal bridges, and increases cellular and vascular response [ 44 , 45 ]. However, to our knowledge, calcium-based biomaterials and no light-cured calcium silicate-based (MTA and Biodentine) remain the best options for dental pulp capping.…”

Section: Discussionmentioning

confidence: 99%

Clinical Efficacy of Biomimetic Bioactive Biomaterials for Dental Pulp Capping: A Systematic Review and Meta-Analysis

et al. 2022

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Recently, biomimetic bioactive biomaterials have been introduced to the market for dental pulp capping. This systematic review and meta-analysis aimed to determine any variation between the effect of using TheraCal LC and other bioactive biomaterials for pulp capping is different, as measured by dentin increment and clinical success. The risk of bias was assessed using the Risk of Bias 2 and Newcastle–Ottawa tools for randomized clinical trials and observational studies. A search for relevant articles was performed on five databases. Additionally, the quality of the included studies was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) criteria. A summary of individual studies and a meta-analysis were performed. The odds ratio of data from clinical success was combined using a random-effects meta-analysis. The meta-analysis results showed homogeneity between the studies (I2 = 0%). They revealed that the clinical success showed no differences between the patients who received TheraCal LC, light-cured calcium silicate-based biomimetic biomaterial, for dental pulp capping or the comparator biomaterials (p > 0.5). However, the certainty of the evidence was low to moderate due to the risk of bias in the included studies.

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“… [ 56 ] NHA+FGF2 Further enhancing the formation of calcified tissue [ 57 ] NHA/SB SB increases the adhesion capacity of NHA. [ 58 ] Zn-Si-CaNPs ZnNPs can down-regulate the expression of M1-macrophages. [ 59 ] nCur Combined with aPDT produces a long-lasting anti-inflammatory effect.…”

Section: Cariesmentioning

confidence: 99%

“…NHAP, as a scaffold material loading fibroblast growth factor-2 (FGF2), can efficiently enhance the formation of calcified tissue [ 57 ]. Considering that NHAP cannot have the ability to adhere, Yoshida et al applied a dental adhesive super-bond in combination with NHAP for pulp capping and showed that dense restorative dentin was produced in the exposed areas of the pulp [ 58 ]. In addition to promoting restorative dentin formation, anti-inflammatory treatment is crucial to the success of pulp capping.…”

Section: Pulpal Diseasesmentioning

confidence: 99%

Advanced materials and technologies for oral diseases

Cui

You

Cheng

et al. 2023

Science and Technology of Advanced Materials

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Oral disease, as a class of diseases with very high morbidity, brings great physical and mental damage to people worldwide. The increasing burden and strain on individuals and society make oral diseases an urgent global health problem. Since the treatment of almost all oral diseases relies on materials, the rapid development of advanced materials and technologies has also promoted innovations in the treatment methods and strategies of oral diseases. In this review, we systematically summarized the application strategies in advanced materials and technologies for oral diseases according to the etiology of the diseases and the comparison of new and old materials. Finally, the challenges and directions of future development for advanced materials and technologies in the treatment of oral diseases were refined. This review will guide the fundamental research and clinical translation of oral diseases for practitioners of oral medicine.

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Development of a novel direct dental pulp-capping material using 4-META/MMA-TBB resin with nano hydroxyapatite

Cited by 15 publications

References 49 publications

Assessment of the biointeractivity of a novel vital pulp therapy agent derived from eggshell biowaste: An in vitro study

Assessment of the biointeractivity of a novel vital pulp therapy agent derived from eggshell biowaste: An in vitro study

Clinical Efficacy of Biomimetic Bioactive Biomaterials for Dental Pulp Capping: A Systematic Review and Meta-Analysis

Advanced materials and technologies for oral diseases

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