Development of a novel DNA delivery system based on rice bran polysaccharide-Fe(III) complexes

Synthesis, Characterization, and Bioactivities of Polysaccharide Metal Complexes: A Review

“…26 Liu et al determined the content of carbon, nitrogen, and hydrogen in polyethylenimine (PEI)-modified rice bran polysaccharide-Fe(III) complex (PEI−PI) at 42%, 16.5%, and 9.6%, respectively, through the elemental analysis. 21 Wang et al reported that the G-factor in the EPR spectrum of IOPS and its iron(III) complex was significantly different, and the complex had a FeOOH type signal, which suggested that IOPS formed a complex with iron(III). 51 Bioactivity of Polysaccharide Metal Complexes.…”

“…For instance, the complex (LPIC) produced by the combination of low molecular weight ulva polysaccharide and Fe(III) ions can effectively protect mice from radiation damage; 65 APS-Fe(III) exhibits high immunomodulatory activity, and its proliferation-promoting and complement fixation activities of lymphocytes are better than those of APS; 24 the complex (PEI−PI) generated through the combination of the polyethylenimine (PEI) modified rice bran polysaccharide and Fe(III) ions can induce DNA condensation at low doses, thus revealing it has stronger DNA condensation capacity, and Fe(III) ions were suggested to improve cellular uptake efficiency and vector/pDNA multimer gene transfection efficiency, which can be applied to the development of novel DNA delivery systems. 21 The chondroitin sulfate zinc (CSZn) complex could facilitate wound healing by promoting the production of fibroblast growth factor β (β-FGF), collagen III (COLIIIα1), vascular endothelial growth factor (VEGF), and reducing cytokines IL-6, IL-1β, and TNF-α. Summary and Future Perspectives.…”

“…For instance, Deng et al confirmed through AFM imaging that EUP and its complex (EUP-Sr) were nanoparticles with a height of less than 60 nm, and the particle size of EUP-Sr was smaller than that of EUP . Liu et al determined the content of carbon, nitrogen, and hydrogen in polyethylenimine (PEI)-modified rice bran polysaccharide-Fe­(III) complex (PEI–PI) at 42%, 16.5%, and 9.6%, respectively, through the elemental analysis . Wang et al reported that the G-factor in the EPR spectrum of IOPS and its iron­(III) complex was significantly different, and the complex had a FeOOH type signal, which suggested that IOPS formed a complex with iron­(III) …”

“…Large-molecule polysaccharide metal complexes exhibit higher safety and water solubility as compared with traditional small-molecule metal complexes. It is noteworthy that the biological activity of polysaccharides could be enhanced by the synergistic interaction between polysaccharides and metal ions. − The preparation of polysaccharide metal complexes from single polysaccharides can be used as a promising method used to develop novel drugs. For example, polysaccharide-iron complexes are characterized by a high iron supplementation efficiency, better solubility and stability, and fewer side effects, − which have been recognized as novel iron supplements (e.g., Niferex) for the treatment of iron deficiency anemia (IDA).…”

Preparation and characterization of metal–tea polysaccharide complexes and their inhibition on α‐glucosidase

“…The TPSI synthesis process was based on the study with a slight modification (Liu et al, 2020;Pan et al, 2018).…”