Development of a novel endothelial cell‐seeded endovascular stent for intracranial aneurysm therapy

Zhu, Wei; Tian, Ye; Zhou, Liangfu; Wang, Yan; Song, Dong Ho; Mao, Ying; Yang, Guoyuan

doi:10.1002/jbm.a.31592

Cited by 12 publications

(9 citation statements)

References 24 publications

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“…The current treatment for IA mainly involves clipping for surgical intervention and endovascular coiling based on its special characteristics. Experimental aneurysm studies have mainly focused on endothelial cells, such as the autologous endothelial cell-seed stent ( Zhu et al, 2008 ) and enhanced aneurysm neck endothelialization by erythropoietin-induced endothelial progenitor cell stimulation ( Liu et al, 2016 ). In addition, endothelial injury may result from the reaction and migration of SMCs to the tunica intima ( Etminan and Rinkel, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Myosin Light Chain Kinase on the Occurrence and Development of Intracranial Aneurysm

Song

Liu

et al. 2018

Front. Cell. Neurosci.

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Myosin light chain kinase is a key enzyme in smooth muscle cell contraction. However, whether myosin light chain kinase plays a role in the occurrence or development of intracranial aneurysms is not clear. The present study explored the function of myosin light chain kinase in human intracranial aneurysm tissues. Five aneurysm samples and five control samples were collected, and smooth muscle cells (SMCs) were dissociated and cultured. A label-free proteomic analysis was performed to screen the differentially expressed proteins between aneurysm and control samples. The expression and function of myosin light chain kinase in aneurysms were examined. We found that 180 proteins were differentially expressed between the aneurysm and control samples, among which 88 were increased and 92 (including myosin light chain kinase) were decreased in aneurysms compared to control tissues. In a model of the inflammatory environment, contractility was weakened and apoptosis was increased in aneurysm SMCs compared to human brain SMCs (p < 0.05). The knock down of myosin light chain kinase in human brain SMCs caused effects similar to those observed in aneurysm SMCs. These results indicated that myosin light chain kinase plays an important role in maintaining smooth muscle contractility, cell survival and inflammation tolerance.

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Section: Introductionmentioning

confidence: 99%

The Effect of Myosin Light Chain Kinase on the Occurrence and Development of Intracranial Aneurysm

Song

Liu

et al. 2018

Front. Cell. Neurosci.

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“…5,6 Therefore, minimizing the time required to obtain a layer of functional endothelial cells is an essential factor for material biocompatibility. [7][8][9][10][11] However, implantation of a stent may cause a marked and long-lasting dysfunction of intra-arterial endothelial cells.…”

Section: Introductionmentioning

confidence: 99%

Kinetics of endothelialization of the multilayer flow modulator and single-layer arterial stents

et al. 2015

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The multilayer flow modulator (MFM; Cardiatis, Isnes, Belgium) is a self-expandable mesh of braided cobalt alloy wires, used for treatment of aortic and peripheral aneurysms. To further improve our understanding of this novel technology, the endothelialization kinetics of the MFM was investigated and compared with those of two marketed single-layer stents. Five porcine animal models were used in which a total of 19 stents were implanted in the iliac and carotid arteries between one and five weeks before sacrifice. All 19 stents were successfully delivered. For all devices, nonsignificant signs of inflammation or thrombosis were noted, and there was no evidence of local intolerance. The MFM developed a thin layer of endothelial cells earlier and was associated with less neointimal development than the two single-layer stents. A differing phenomenon of integration was also revealed and hypothesized as endothelialization from adhesion of circulating endothelial progenitor cells, as well as adhesion from the arterial wall, and also by the differences in trauma exposed to the arterial wall.

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“…Stent is known to reduce aneurysm recurrence rate by instent endothelialization, possible f low diversion effect, and eventual isolation of the aneurysm from the circulation [17,18]. TemSAT does not provide this theoretical chance.…”

Section: Discussionmentioning

confidence: 99%

Selective Temporary Stent-Assisted Coil Embolization for Intracranial Wide-Necked Small Aneurysms Using Solitaire AB Retrievable Stent

Heo

Ahn

et al. 2019

J Korean Neurosurg Soc

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ObjectiveStent-assisted coil embolization of intracranial wide-necked aneurysm requires long-term postoperative antiplatelet therapy to prevent in-stent thrombosis. This study aimed to demonstrate results of temporary stent placement for coiling wide necked small intracranial aneurysms, which eliminated need for antiplatelet agents, and to discuss its feasibility and safety. MethodsData of 156 patients who underwent stent-assisted coil embolization between 2011 and 2014 were retrospectively analyzed. Thirteen cases of temporary stent-assisted coil embolization were included, and their clinical and radiological results were evaluated. ResultsThe aneurysms treated were all unruptured except one case. All of them had wide neck with mean dome-to-neck ratio of 0.96 and were small-sized aneurysms with mean maximal diameter of 4.2 mm. There was no technical failure in retrieval of stent after completion of embolization of the target aneurysm. Immediate angiography revealed 11 complete and two partial embolization (one residual neck and one residual aneurysm). Two cases encountered thrombosis complication, and they were managed without neurological sequelae. The mean follow-up period was 43 months, angiographic follow-up revealed two cases with minor recurrence, and clinical outcome was good with modified Rankin scale score of 0. ConclusionTemporary stent-assisted coil embolization of small wide-necked intracranial aneurysm using fully retrievable stent appears safe and effective. Further application and evaluation of this technique in more cases with larger size aneurysm is warranted.

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Development of a novel endothelial cell‐seeded endovascular stent for intracranial aneurysm therapy

Cited by 12 publications

References 24 publications

The Effect of Myosin Light Chain Kinase on the Occurrence and Development of Intracranial Aneurysm

The Effect of Myosin Light Chain Kinase on the Occurrence and Development of Intracranial Aneurysm

Kinetics of endothelialization of the multilayer flow modulator and single-layer arterial stents

Selective Temporary Stent-Assisted Coil Embolization for Intracranial Wide-Necked Small Aneurysms Using Solitaire AB Retrievable Stent

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