Development of a Patient-specific Tumor Mold Using Magnetic Resonance Imaging and 3-Dimensional Printing Technology for Targeted Tissue Procurement and Radiomics Analysis of Renal Masses

Dwivedi, Durgesh K.; Chatzinoff, Yonatan; Zhang, Yue; Yuan, Qing; Fulkerson, Michael; Chopra, Rajiv; Brugarolas, James; Cadeddu, Jeffrey A.; Kapur, Payal; Pedrosa, Iván

doi:10.1016/j.urology.2017.08.056

Cited by 34 publications

(47 citation statements)

References 29 publications

(29 reference statements)

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“…This review shows that with use of low-cost materials or home-made 3D printers, the cost associated with 3D printed kidney models is less than USD$150, as shown in some studies (25,27,28,33). However, a high quality kidney model printed with flexible materials such as TangoPlus and with different colours to highlight renal tumours and vascular or renal collecting structures can cost up to USD$1,000 (15,16,18,26). Therefore, future research is needed to reduce the costs associated with 3D printed kidney models.…”

Section: Discussionmentioning

confidence: 99%

“…There are 7 studies reporting the qualitative assessment of 3D printed models in renal disease (15,17,(25)(26)(27)(28)31). Three of them showed that patient's understanding of renal anatomy and pathology was improved with use of 3D printed models, with patient's satisfaction score more than 9 out of 10 (15,25,31).…”

Section: Qualitative Assessment Of 3d Printed Kidney Modelsmentioning

confidence: 99%

“…Another three studies demonstrated the clinical value of using 3D printed models in pre-operative planning or simulation of surgical procedures, which led to reduction of surgery duration and intraoperative complications, as well as assisting renal transplantation surgery (17,27,28). The remaining study by Dwivedi et al presented their first report of correlating 3D printed renal molds with MRI tumour features, with the aim of providing opportunities for future studies of radiomic and radiogenomic analysis of renal tumours (26).…”

Section: Qualitative Assessment Of 3d Printed Kidney Modelsmentioning

confidence: 99%

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A systematic review of clinical value of three-dimensional printing in renal disease

Sun

Liu

2018

Quant. Imaging Med. Surg.

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The aim of this systematic review is to analyse current literature related to the clinical value of three-dimensional (3D) printed models in renal disease. A literature search of PubMed and Scopus databases was performed to identify studies reporting the clinical application and usefulness of 3D printed models in renal disease. Fifteen studies were found to meet the selection criteria and were included in the analysis. Eight of them provided quantitative assessments with five studies focusing on dimensional accuracy of 3D printed models in replicating renal anatomy and tumour, and on measuring tumour volume between 3D printed models and original source images and surgical specimens, with mean difference less than 10%. The other three studies reported that the use of 3D printed models significantly enhanced medical students and specialists' ability to identify anatomical structures when compared to two-dimensional (2D) images alone; and significantly shortened intraoperative ultrasound duration compared to without use of 3D printed models. Seven studies provided qualitative assessments of the usefulness of 3D printed kidney models with findings showing that 3D printed models improved patient's understanding of renal anatomy and pathology; improved medical trainees' understanding of renal malignant tumours when compared to viewing medical images alone; and assisted surgical planning and simulation of renal surgical procedures with significant reductions of intraoperative complications. The cost and time associated with 3D printed kidney model production was reported in 10 studies, with costs ranging from USD$100 to USD$1,000, and duration of 3D printing production up to 31 h. The entire process of 3D printing could take up to a few days. This review shows that 3D printed kidney models are accurate in delineating renal anatomical structures and renal tumours with high accuracy. Patient-specific 3D printed models serve as a useful tool in preoperative planning and simulation of surgical procedures for treatment of renal tumours. Further studies with inclusion of more cases and with a focus on reducing the cost and 3D model production time deserve to be investigated.

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Section: Discussionmentioning

confidence: 99%

Section: Qualitative Assessment Of 3d Printed Kidney Modelsmentioning

confidence: 99%

Section: Qualitative Assessment Of 3d Printed Kidney Modelsmentioning

confidence: 99%

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A systematic review of clinical value of three-dimensional printing in renal disease

Sun

Liu

2018

Quant. Imaging Med. Surg.

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“…Removing or trimming the fat may interfere with clinical practice, as it could compromise the surgical margins, which need to be evaluated for the presence of tumour cells 29 . A solution has been previously proposed for partial nephrectomy cases, using the inner parenchymal surface of the tumour as the base of the mould 25 . This method involved the surgeon inserting fiducial markers into the tumour during surgery, which interrupts the routine clinical pathway.…”

Section: Discussionmentioning

confidence: 99%

“…Finally, the specimen is often covered by perinephric fat 23 , which further complicates the procedure and can make it impossible to identify relevant structures. Because of these restrictions, previous 3Dprinting-based co-registration methods for RCC have either been limited to pre-clinical models 24 , or have only focused on early-stage partial nephrectomy cases 25 , where the fat-free resection margin can be used as a base. In addition, none of the preivous methods addressed the issue of having di↵erent sectioning and imaging planes.…”

Section: Introductionmentioning

confidence: 99%

3D-printed moulds for image-guided surgical biopsies: an open source computational platform

Crispín-Ortuzar

Gehrung

Ursprung

et al. 2019

Preprint

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PURPOSESpatial heterogeneity of tumours is a major challenge in precision oncology. The relationship between molecular and imaging heterogeneity is still poorly understood, as it relies on the accurate co-registration of medical images and tissue biopsies. tumour moulds can guide the localization of biopsies, but their creation is time consuming, technologically challenging, and di cult to interface with routine clinical practice. These hurdles have so far hindered the progress in the area of multiscale integration of tumour heterogeneity data. METHODSWe have developed an open source computational framework to automatically produce patientspecific 3D-printed moulds that can be used in the clinical setting. Our approach achieves accurate co-registration of sampling location between tissue and imaging, and integrates seamlessly with clinical, imaging and pathology workflows. RESULTSWe applied our framework to patients with renal cancer undergoing radical nephrectomy. We created personalised moulds for five patients, obtaining Dice similarity coe cients between imaging and tissue sections ranging from 0.86 to 0.93 for tumour regions, and between 0.70 and 0.76 for healthy kidney. The framework required minimal manual intervention, producing the final mould design in just minutes, while automatically taking into account clinical considerations such as a preference for specific cutting planes. CONCLUSIONOur work provides a robust and automated interface between imaging and tissue samples, enabling the development of clinical studies to probe tumour heterogeneity on multiple spatial scales.

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3D printing with MRI in pediatric applications

Parthasarathy

Krishnamurthy

Ostendorf

et al. 2019

Magnetic Resonance Imaging

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3D printing (3DP) applications for clinical evaluation, preoperative planning, patient and trainee education, and simulation has increased in the past decade. Most of the applications are found in cardiovascular, head and neck, orthopedic, neurological, urological, and oncological surgical cases. This review has three parts. The first part discusses the technical pathway to realizing a physical model, 3DP considerations in pediatric MRI image acquisition, data and resolution requirements, and related structural segmentation and postprocessing steps needed to generalize both virtual and physical models. Standard practices and processing software used in these processes will be assessed. The second part discusses complementary examples in pediatric applications, including cases from cardiology, neuroradiology, neurology, and neurosurgery, head and neck, orthopedics, pelvic and urological applications, oncological applications, and fetal imaging. The third part explores other 3D printing applications and considerations such as using 3DP to develop tissue‐specific phantoms and devices for testing in the MR environment, to educate patients and their families, to train clinicians and students, and facility requirements for building a 3DP program.Level of Evidence: 5Technical Efficacy: Stage 5J. Magn. Reson. Imaging 2020;51:1641–1658.

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Development of a Patient-specific Tumor Mold Using Magnetic Resonance Imaging and 3-Dimensional Printing Technology for Targeted Tissue Procurement and Radiomics Analysis of Renal Masses

Abstract: MRI-based preoperative 3D printing of tumor-specific molds allow for accurate sectioning of the tumor after surgical resection and colocalization of in vivo imaging features with tissue-based analysis in radiomics and radiogenomic studies.

Cited by 34 publications

References 29 publications

A systematic review of clinical value of three-dimensional printing in renal disease

A systematic review of clinical value of three-dimensional printing in renal disease

3D-printed moulds for image-guided surgical biopsies: an open source computational platform

3D printing with MRI in pediatric applications

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