2001
DOI: 10.1002/mrm.10029
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Development of a PEDRI free‐radical imager using a 0.38 T clinical MRI system

Abstract: Proton electron double resonance imaging (PEDRI) uses the Overhauser effect to image the distribution of free-radicals in biological samples and animals. Standard MRI hardware and software is used, with the addition of hardware to irradiate the free-radical-of-interest's EPR resonance. For in vivo applications it must be implemented at a sufficiently low magnetic field to result in an EPR irradiation frequency that will penetrate the sample but will not cause excessive nonresonant power deposition therein. Man… Show more

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Cited by 70 publications
(60 citation statements)
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“…247 Interestingly, whole body EPR systems have been built in the last few years in Hanover (USA), Columbus (USA), Chicago (USA) and Aberdeen (UK). 248,249 In addition, special coils (including implantable coils and catheter-resonators) have been developed. It appears that there is now ample opportunity for pioneering research using in vivo EPR in humans.…”
Section: Instrumental Developmentsmentioning
confidence: 99%
“…247 Interestingly, whole body EPR systems have been built in the last few years in Hanover (USA), Columbus (USA), Chicago (USA) and Aberdeen (UK). 248,249 In addition, special coils (including implantable coils and catheter-resonators) have been developed. It appears that there is now ample opportunity for pioneering research using in vivo EPR in humans.…”
Section: Instrumental Developmentsmentioning
confidence: 99%
“…In order to measure ROS, several methods have been developed including optical redox scanning 15 and exogenous contrast magnetic resonance imaging (MRI)-based methods. [16][17][18][19][20][21] Optical redox scanning acquires ex vivo fluorescence images from endogenous reduced nicotinamide adenine dinucleotide (NADH) and oxidized flavoproteins (Fp) in order to map the tissue redox state that is related to ROS-induced oxidative stress. 15 However, this technique is invasive and only applicable to ex vivo tissues.…”
mentioning
confidence: 99%
“…The use of a high-Q receive coil in this instance would result in the frequency-encoded signal outside of the narrow coil response function being attenuated significantly [43,47], possibly to the extent of being unrecoverable via post processing. Thus, we have employed low-Q coils with a high filling factor design to mitigate the issue of finite coil bandwidth at low frequencies [60][61][62]. Lowering the coil Q results in a slight, but inevitable trade-off in image SNR [60,62], however the large signal obtained from hyperpolarized samples allows this to be tolerated to some degree.…”
Section: Hardware Performancementioning
confidence: 99%