Development of a pH-responsive drug delivery system for enantioselective-controlled delivery of racemic drugs

Suedee, Roongnapa; Jantarat, Chutima; Lindner, Wolfgang; Viernstein, Helmut; Songkro, Sarunyoo; Srichana, Teerapol

doi:10.1016/j.jconrel.2009.10.011

Cited by 104 publications

(50 citation statements)

References 20 publications

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“…The pH-responsive releasing of (S)-oeprazole was due to the PHEMA polymer in the composite latex, which was mainly functioned as a barrier to provide sustained release of the required pH-dependent drug. Moreover, the results demonstrate that drug delivery systems containing (S)-omeprazole imprinted nanoparticles displayed maximum efficacy while minimizing dose frequency [60].…”

Section: Ph-responsive Molecularly Imprinted Polymersmentioning

confidence: 91%

“…In addition, dendrimers such as polyethyleneimine (PEI) modified with methacryl groups was can also reversibly be opened and closed in response to pH [100]. Therefore, MIPs based on pH-responsive polyelectrolytes should demonstrate pH-dependent recognition and such systems have therefore been considered as promising materials for controlled drug delivery [59,60,101].…”

Section: Ph-responsive Molecularly Imprinted Polymersmentioning

confidence: 99%

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Molecularly Imprinted Polymers with Stimuli-Responsive Affinity: Progress and Perspectives

et al. 2015

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Intelligent stimuli-responsive molecularly imprinted polymers (SR-MIPs) have attracted considerable research interest in recent years due to the potential applications in drug delivery, biotechnology and separation sciences. This review comprehensively summarizes various SR-MIPs, including the design and applications of thermo-responsive MIPs, pH-responsive MIPs, photo-responsive MIPs, biomolecule-responsive MIPs and ion-responsive MIPs. Besides the development of current SR-MIPs, the advantages as well as the disadvantages of current SR-MIPs were also displayed from different angles, especially preparation methods and application fields. We believe this review will be helpful to guide the design, development and application of SR-MIPs.Polymers 2015, 7 1690

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Section: Ph-responsive Molecularly Imprinted Polymersmentioning

confidence: 91%

Section: Ph-responsive Molecularly Imprinted Polymersmentioning

confidence: 99%

Molecularly Imprinted Polymers with Stimuli-Responsive Affinity: Progress and Perspectives

et al. 2015

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“…thermo-response, pH response, photoresponse) (Liechty et al, 2010;Puoci et al, 2008a;Suedee et al, 2010) factors, swelling behavior of MIP particles, and hydrophobicity and hydrophilicity to tailor the properties of MIPs for desired materials. For example, Puoci's group (2004) synthesized spherical MIPs (SMIPs) via novel precipitation polymerization approach using sulfasalazine and studied the effect of pH on drug release profiles of SMIPs and spherical non-imprinted polymers (SNIPs as seen in Figure 7).…”

Section: Mips In Oral Therapeutic Applicationsmentioning

confidence: 99%

Molecular imprinted polymers as drug delivery vehicles

Zaidi

2014

Drug Delivery

111

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This review is aimed to discuss the molecular imprinted polymer (MIP)-based drug delivery systems (DDS). Molecular imprinted polymers have proved to possess the potential and also as a suitable material in several areas over a long period of time. However, only recently it has been employed for pharmaceuticals and biomedical applications, particularly as drug delivery vehicles due to properties including selective recognition generated from imprinting the desired analyte, favorable in harsh experimental conditions, and feedback-controlled recognitive drug release. Hence, this review will discuss their synthesis, the reason they are selected as drug delivery vehicles and for their applications in several drug administration routes (i.e. transdermal, ocular and gastrointestinal or stimuli-reactive routes).

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“…Omeprazole-imprinted nanoparticles-on-microspheres were prepared using methacryloyl quinine and methacryloyl quinidine as functional monomers and ethylene glycol dimethacrylate as a cross-linker. The latex obtained was incorporated into a pH-responsive network of poly(hydroxyethyl methacrylate) and polycaprolactone-triol enabling the triggering of drug release at pH > 6.8; the MIP (molecularly imprinted polymer) regulating the release rate of each enantiomer (Figure 18.16) [234]. Precipitation polymerization is one of the simplest approaches to synthesize uniform microspheres [235,236].…”

Section: Polymeric Particles From Monomersmentioning

confidence: 99%