Molecular imprinted polymers as drug delivery vehicles

Abstract

This review is aimed to discuss the molecular imprinted polymer (MIP)-based drug delivery systems (DDS). Molecular imprinted polymers have proved to possess the potential and also as a suitable material in several areas over a long period of time. However, only recently it has been employed for pharmaceuticals and biomedical applications, particularly as drug delivery vehicles due to properties including selective recognition generated from imprinting the desired analyte, favorable in harsh experimental conditions, and feedback-controlled recognitive drug release. Hence, this review will discuss their synthesis, the reason they are selected as drug delivery vehicles and for their applications in several drug administration routes (i.e. transdermal, ocular and gastrointestinal or stimuli-reactive routes).

Thermo‐sensitive surface molecularly imprinted magnetic microspheres based on bio‐macromolecules and their specific recognition of bovine serum albumin

“…Protein molecularly imprinted polymers (MIPs) are functionally polymeric materials that specifically recognize template proteins . Thus far, MIPs have shown wide application prospects in many fields, such as chemical bionic sensors , protein separation , natural antibody simulation , and drug sustained release . However, the protein bio‐macromolecules of the corresponding MIPs are disadvantaged by weak specificity of the functional groups, large size, and flexible conformations, which challenge their design and preparation .…”

“…Protein molecularly imprinted polymers (MIPs) are functionally polymeric materials that specifically recognize template proteins [1,2]. Thus far, MIPs have shown wide application prospects in many fields, such as chemical bionic sensors [3,4], protein separation [5][6][7], natural antibody simulation [8][9][10], and drug sustained release [11,12]. However, the protein bio-macromolecules of the corresponding MIPs are disadvantaged by weak specificity of the functional groups, large size, Article Related Abbreviations: IF, Imprinting factor; LCST, lower critical solution temperature; MCS, modified chitosan; MIPs, Protein molecularly imprinted polymers; NIPAM, N-isopropylacrylamide; NIPs, Non-imprinted polymer microspheres; Q, Adsorption amount (mg/g); SBMA, sulfobetaine methacrylate; β, selection factor.…”

Molecular imprinted photonic crystal for sensing of biomolecules

“…Since the idea of molecular imprinting was first put forward by Pauling in 1940s [43], over the past decades, it is well known that molecular imprinting is a very promising and rapidly evolving technology, with many possible applications such as preparative analytical separations [44][45], enzyme-like catalysis [46][47], solidphase extractions [48][49], chemical sensors [50][51] and drug delivery [52][53], etc. Molecular imprinting has proven to be particularly successful for small molecules.…”

Perspectives of Molecularly Imprinted Polymer-Based Drug Delivery Systems in Cancer Therapy

“…More work is required to decode their full potential, to overcome some of the issues related to the imprinting process currently not in line with the modern pharmacotherapeutic requirements [11], to assess their safety profile, and finally to reach the ultimate goal, clinical translation. Excellent reviews on MIP-DDS intended for various routes of administration (topical, enteral, and parenteral) have been published by Lulinski et al and Tuwahatu et al [12][13][14][15]. Nevertheless, our review aims to summarize the present state-of-the art of MIP-based DDS focused on anticancer therapy, emphasizing particularities of the chemotherapeutics release and discussing the current challenges and future perspectives of these unique drug carriers.…”