Development of a potentiometric maprotiline-selective electrode and its application in pharmaceutıcal samples

Çavuş, İbrahim; Kanberoğlu, Gülşah Saydan

doi:10.1016/j.microc.2019.04.050

Cited by 6 publications

(10 citation statements)

References 35 publications

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“…GC‐FID analysis of the studied pharmaceutical samples were also carried out for the comparison of the potentiometric results (see Figure 10). While performing GC‐FID analyzes of the samples, the analysis protocol used in the previous study [19] was followed. The obtained potentiometric and GC‐FID analysis results with their statistical interpretations were summarized in Table 4.…”

Section: Resultsmentioning

confidence: 99%

“…Up to the present, MAP determination has been performed through various analytical techniques such as HPLC, [5–7] spectrophotometry, [8–10] LC, [11] GLC‐MS, [12] GS‐MS, [13] reverse‐phase ultra‐fast liquid chromatographic (RP‐UFLC), [14] capillary zone electrophoresis (CZE), [15,16] LC/ESI‐CID/MS, [17] HPLC/chemiluminescence [18] and potentiometry [19] …”

Section: Introductionmentioning

confidence: 99%

“…To our knowledge, there is only one study concerning the potentiometric maprotiline‐selective electrode [19] . In this previous study, a PVC membrane maprotiline selective electrode was prepared based on the ion‐pair of maprotiline with tetraphenyl borate as ionophore as in conventional drug selective electrode preparation.…”

Section: Introductionmentioning

confidence: 99%

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Development of a PVC Membrane Potentiometric Sensor with Low Detection Limit and Wide Linear Range for the Determination of Maprotiline in Pharmaceutical Formulations

et al. 2022

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Maprotiline (MAP), is an active ingredient of some antidepressants which has been broadly used for the therapy of depression. The overdose of MAP in the treatment of patients with depression can lead to significant side effects, even lethal intoxication. Therefore, it is very important to develop simple, inexpensive, fast and reliable detection methods for MAP in interested samples. In our present study, we have offered a novel poly(vinylchloride) (PVC) membrane maprotiline‐selective potentiometric sensor based on a type of MOFs, known as MIL‐53(Al), as electroactive ionophore substance. The sensor prepared at the optimum membrane composition exhibited a linear response for maprotiline hydrochloride in the concentration range of 1,0×10−9 M−1,0×10−2 M with a slope of 59,1 mV/decade and detection limit of 9,0×10−10 M. The pH working range of the sensor was determined as 2,0–9,5. The response time of the sensor was very fast and less than 5 s. With these performance features, it has been shown that the current sensor has quite superior features compared to the potentiometric MAP‐selective sensor available in the literature. The potentiometric application of the sensor was successfully carried out with the detection of MAP in pharmaceutical tablets containing MAP‐HCl.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Development of a PVC Membrane Potentiometric Sensor with Low Detection Limit and Wide Linear Range for the Determination of Maprotiline in Pharmaceutical Formulations

et al. 2022

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“…In wide variety of applications, various ions in aqueous solutions were determined using ionselective electrodes (ISEs) [9][10][11]. In comparison with other analytical methods, they are relatively inexpensive and simple to use [12][13][14][15]. Carbonpaste electrodes (CPEs) have several advantages of very low Ohmic resistance, low cost, very short response time , reproducibility of the preparation process, very simple, cheep and quick preparation process.…”

Section: Introductionmentioning

confidence: 99%

Highly sensitive electrochemical sensor determination of drug in pharmaceutical analysis

2020

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M ODIFED carbon paste electrodes and screen printed electrodes were developed for the potentiometric determination of butenaFne hydrochloride (BTFHC) in urine, serum and pharmaceutical preparations. Two modiFed carbon paste electrodes (electrodes A and C) and two modiFed screen printed electrodes (electrodes B and D) using tricresylphosphate (TCP) and o-nitrophenyloctyl ether (o-NPOE) plasticizers, respectively, were used. The electrodes showed a linear concentration range from 1.57×10-7 to 1.0 × 10-2 and 1.0 × 10-7 to 1.0 × 10-2 mol L-1 with detection limit of 1.57×10-7 and 1.0 × 10-7 mol L-1 for modiFed carbon paste (MCPEs; electrodes A and B) and modiFed screen printed (MSPEs; electrodes C and D), respectively. The calibration graphs have slope values of 56.95±0.56, 58.22±0.78, 56.18±0.66 and 57.69±0.39 mV decade-1 for electrodes A, B, C and D, respectively. The response time was relatively quick in the whole concentration range and was found to be 12s for electrodes (A and B) and 7s for electrodes (C and D). The electrodes were found to have life time of 82, 99, 160 and 185 days without showing any deviations in a pH range of 5.0-9.0 and 4.0-9.0 for MCPEs (electrodes A and B) and MSPEs electrodes (C and D), respectively. The fabricated electrodes displayed good selectivity for BTFHC with respect to number of common foreign inorganic cations, sugar species, organic and glycine as the Fllers that may be added to the pharmaceutical preparation or biological fluids. Fortunately, such materials mostly do not interfere. The potential application of the sensors (A-D) was accomplished as a result of good recoveries made from real samples fortiFed with BTFHC. Results indicated the proFciency of the sensors reliable for rapid, onsite monitoring of BTFHC in pharmaceutical preparation and in biological samples.

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“…In the literature, it is seen that selective potentiometric sensors for drug active substances is generally fabricated by using the ion-pairs of the target drug active substances as ionophore in the cunstruction of PVC membrane electrode. Numerous studies and reviews on electrodes prepared in this way are available in the literatüre [16][17][18][19][20][21]. An overview of literature indicated that there is only one work regarding the fabrication of isoprenaline-selective potentiometric electrode [22] In the mentioned study a PVC-membrane electrode were prepared based on naphthylethylenediaminetetraphenylborate ion pair as electroactive material.…”

Section: Introductionmentioning

confidence: 99%

Farmasötik İlaçta İzoprenalin Tayini İçin Potansiyometrik Sensör Geliştirilmesi

Kanberoğlu

Özarslan²

2020

El-Cezeri Fen Ve Mühendislik Dergisi

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In this study, a potentiometric ion-selective electrode (ISE) was developed for the determination of isoprenaline, a pharmaceutical active substance. For this purpose, initially, IP-PM, IP-TCA, IP-TPB, IP-REY, IP-PTA ion pairs were synthesized. The synthesized ion pairs were used as the ionophore in the structure of the electrode membrane. In order to ensure membrane optimization, PVC membrane ion selective electrodes were produced in various compositions using the synthesized ion pair and the potentiometric performance characteristics of these electrodes were investigated. It was determined that the best potentiometric performance characteristics were obtained with the PVC membrane electrode in the composition of 3.0% isoprenalinetetrafenylborate ion pair, %64.0 nitrophenyloctylether, 32.0% polyvinylchloride and %1.0 Tetrakis (4chlorophenyl) boron potassium compound. The linear operating range of this electrode is 5.0x 10-6 M-1.0x 10-1 M and the slope at the 10-fold concentration change is 45.3 mV; determination limit, 5.0x10-6 M, pH working range, 2.6-3.6 and 5.7-7.9; response time < 5s. The electrode exhibited a reproducible potentiometric response. Isoprenaline content was determined in drug by using the isoprenaline selective electrode.

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Development of a potentiometric maprotiline-selective electrode and its application in pharmaceutıcal samples

Cited by 6 publications

References 35 publications

Development of a PVC Membrane Potentiometric Sensor with Low Detection Limit and Wide Linear Range for the Determination of Maprotiline in Pharmaceutical Formulations

Development of a PVC Membrane Potentiometric Sensor with Low Detection Limit and Wide Linear Range for the Determination of Maprotiline in Pharmaceutical Formulations

Highly sensitive electrochemical sensor determination of drug in pharmaceutical analysis

Farmasötik İlaçta İzoprenalin Tayini İçin Potansiyometrik Sensör Geliştirilmesi

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