Development of a Rat Model of Mandibular Irradiation Sequelae for Preclinical Studies of Bone Repair

Microstructural changes in the irradiated and osteoradionecrotic bone: a SEM study

“…Human mandibular bone is at risk of radiation injury due to its superficial location, compact structure, and paucity in vascular supply from inferior alveolar vessels and periosteum. 18 The osteon structure performs a crucial role in bone mechanics and bone turnover. The heterogeneity of the osteon morphology following irradiation has been reported in an animal study.…”

“…The HCs are adaptive to osteocytes as they are positively correlated to the osteon area and the osteocyte number. 24 In animal studies, 16,18,22,25 it has been revealed that irradiation causes changes in the HCs. A progressive decrease in the number of smaller vessels, 26 Haversian vessels, increased occlusion, and a decrease in cellularity have been reported as the long-term change following radiotherapy.…”

“…10,11,13,15,16 Long bones differ in embryological origin and the ossification process compared to the jawbone. 18 Hence, this causes difficulty in transposing results to the jawbone. A recent Raman spectroscopy study 19 has shown that radiation could alter the biochemical composition of the human mandible thereby affecting the quality and mechanical competence of bone.…”

Determination of critical-sized defect of mandible in a rabbit model: Micro-computed tomography, and histological evaluation

“…Many factors contribute to the choice of an animal experimental model for testing bone regeneration strategies [ 7 ]. For mandibular bone regeneration, animal models are generally divided into small (including mice [ 8 ], rats [ [9] , [10] , [11] ], and rabbits [ [12] , [13] , [14] , [15] ]) and large (including dogs [ [16] , [17] , [18] , [19] , [20] , [21] ], goats [ 22 , 23 ], pigs [ 24 , 25 ], and monkeys [ 26 ]) animal models. Animal models usually differ in their mandibular CSDs.…”