Development of a real-time capacitive biosensor for cyclic cyanotoxic peptides based on Adda-specific antibodies

Lebogang, Lesedi; Hedström, Martin; Mattìasson, Bo

doi:10.1016/j.aca.2014.03.028

Cited by 19 publications

(14 citation statements)

References 38 publications

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“…When using current pulse method, the capacitive measurements were performed with an automated flow-injection system as shown in Figure 7 [63]. …”

Section: Applications Of Microcontact Imprinting Methods With Capacmentioning

confidence: 99%

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Capacitive Biosensors and Molecularly Imprinted Electrodes

Ertürk

Mattìasson

2017

Sensors

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Abstract:Capacitive biosensors belong to the group of affinity biosensors that operate by registering direct binding between the sensor surface and the target molecule. This type of biosensors measures the changes in dielectric properties and/or thickness of the dielectric layer at the electrolyte/electrode interface. Capacitive biosensors have so far been successfully used for detection of proteins, nucleotides, heavy metals, saccharides, small organic molecules and microbial cells. In recent years, the microcontact imprinting method has been used to create very sensitive and selective biorecognition cavities on surfaces of capacitive electrodes. This chapter summarizes the principle and different applications of capacitive biosensors with an emphasis on microcontact imprinting method with its recent capacitive biosensor applications.

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“…When using current pulse method, the capacitive measurements were performed with an automated flow-injection system as shown in Figure 7 [63]. …”

Section: Applications Of Microcontact Imprinting Methods With Capacmentioning

confidence: 99%

“…The components shown in the figure are integrated into a box to make a single, portable unit. (Reproduced from Reference [63] with permission).…”

Section: Figurementioning

confidence: 99%

Capacitive Biosensors and Molecularly Imprinted Electrodes

Ertürk

Mattìasson

2017

Sensors

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“…Lebogang et al [62] reported an electrochemical, particularly capacitive immunosensor for broad-spectrum detection of the group of toxic cyclic peptides, called microcystins (∼80 congeners). The sensor can detect at very low concentration range (1 × 10 −13 M to 1 × 10 −10 M) closer to the MC-LR standard, with a limit of detection of 2:1 × 10 −14 M. Yu et al [63] presented an electrochemical sensor for microcystin-LR that exploits a quantum dot/antibody (QD/Ab) probe for signal amplification.…”

Section: Biosensors For Cyanotoxins and Cyanobacteriamentioning

confidence: 99%

“…Due to the wide range concern of endotoxin contamination, LPS biosensors have been largely developed, including optical fiber-based plasmonic sensor [64], colorimetric sensors [65,66], electrochemical sensors [8,67,68], and nanomaterial sensors [69]. The nanomaterial-based LPS sensors have exploited versatile sensing principles, where the nanoparticle either being used as direct signal transducer, i.e., colorimetric sensing based on their aggregation (Figure 4(a)) or as signal amplifier in electrochemical sensors [62,68]. Metal nanoparticle aggregation-based colorimetric sensors are easy to use (mostly with simple mixing, followed by either visual inspection of color change or UV-vis measurement of the absorption spectrum) [70][71][72].…”

Section: Biosensors For Cyanotoxins and Cyanobacteriamentioning

confidence: 99%

Sensors, Biosensors, and Analytical Technologies for Aquaculture Water Quality

Sutarlie

Loh

2020

Research

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In aquaculture industry, fish, shellfish, and aquatic plants are cultivated in fresh, salt, or brackish waters. The increasing demand of aquatic products has stimulated the rapid growth of aquaculture industries. How to effectively monitor and control water quality is one of the key concerns for aquaculture industry to ensure high productivity and high quality. There are four major categories of water quality concerns that affect aquaculture cultivations, namely, (1) physical parameters, e.g., pH, temperature, dissolved oxygen, and salinity, (2) organic contaminants, (3) biochemical hazards, e.g., cyanotoxins, and (4) biological contaminants, i.e., pathogens. While the physical parameters are affected by climate changes, the latter three are considered as environmental factors. In this review, we provide a comprehensive summary of sensors, biosensors, and analytical technologies available for monitoring aquaculture water quality. They include low-cost commercial sensors and sensor network setups for physical parameters. They also include chromatography, mass spectrometry, biochemistry, and molecular methods (e.g., immunoassays and polymerase chain reaction assays), culture-based method, and biophysical technologies (e.g., biosensors and nanosensors) for environmental contamination factors. According to the different levels of sophistication of various analytical techniques and the information they can provide (either fine fingerprint, highly accurate quantification, semiquantification, qualitative detection, or fast screening), we will comment on how they may be used as complementary tools, as well as their potential and gaps toward current demand of real-time, online, and/or onsite detection.

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“…This produced 30 records. Eight of the top 10 sensors (classified by LOD) use nanomaterials, with a capacitive immunosensor using gold nanosphere conjugated antibodies which ranked highest with a LOD of 20 pg/L in freshwater (Lebogang et al, 2014) and a photoelectrochemical aptasensor using graphene in third place with an LOD of 30 pg/L in fish (Du et al, 2016). The 10 least performing sensors (in terms of LOD) are either chromatographic or optical sensors with the latter type at the last position with an LOD of 130 μg/L in algae extracts (Brothier and Pichon, 2013).…”

Section: Analytical Techniques and Their Sensitivitymentioning

confidence: 99%

The end user sensor tree: An end-user friendly sensor database

Nelis

Tsagkaris

Zhao

et al. 2019

Biosensors and Bioelectronics

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Detailed knowledge regarding sensor based technologies for the detection of food contamination often remains concealed within scientific journals or divided between numerous commercial kits which prevents optimal connectivity between companies and end-users. To overcome this barrier The End user Sensor Tree (TEST) has been developed. TEST is a comprehensive, interactive platform including over 900 sensor based methods, retrieved from the scientific literature and commercial market, for aquatictoxins, mycotoxins, pesticides and microorganism detection. Key analytical parameters are recorded in excel files while a novel classification system is used which provides, tailor-made, experts' feedback using an online decision tree and database introduced here. Additionally, a critical comparison of reviewed sensors is presented alongside a global perspective on research pioneers and commercially available products. The lack of commercial uptake of the academically popular electrochemical and nanomaterial based sensors, as well as multiplexing platforms became very apparent and reasons for this anomaly are discussed.

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Development of a real-time capacitive biosensor for cyclic cyanotoxic peptides based on Adda-specific antibodies

Cited by 19 publications

References 38 publications

Capacitive Biosensors and Molecularly Imprinted Electrodes

Capacitive Biosensors and Molecularly Imprinted Electrodes

Sensors, Biosensors, and Analytical Technologies for Aquaculture Water Quality

The end user sensor tree: An end-user friendly sensor database

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