Development of a reversed FIA system for the spectrophotometric determination of Sb(III) and total Sb in antileishmanial drugs

Nanoparticle phosphate-based composites as vehicles for antimony delivery to macrophages: possible use in leishmaniasis

“…These data suggest that distinct NPCs affect the intracellular Sb content differently. In several previous studies, Sb(III) levels after Glucantime exposure have been measured using different techniques, [43][44][45][46][47][48][49][50] but few studies have measured Sb(III) and Sb(V) levels in macrophages. Previous studies have quantified Sb(III) and Sb(V) levels in promastigotes and amastigotes of L. mexicana pifanoi by using absorption spectroscopy with electrothermal atomization.…”

Hyphenated techniques as tools for speciation analysis of metal-based pharmaceuticals: developments and applications

“…The most dangerous of these modifications is reduction to Sb(III), which constitutes a highly toxic chemical species. Because of the difference in the toxicities of the Sb(III) and Sb(V) species, several methods have been described to separate and quantify the species of antimony in pharmaceutical formulations (see Table 1), such as flow-injection hydride generation with spectrophotometric detection [93,94], AAS detection [95], or ICP-AES detection after SPE extraction of the respective species [96]. The levels of Sb(III) found in the drugs were usually 2.4-5.6 % of the total Sb present in the sample.…”

A Coulometric Analysis Method and an Ion-exclusion Chromatographic Method for the Determination of Antimony(V) in Large Excess of Antimony(III)

“…There have been many reports on speciation of antimony(III) and antimony(V) using a wide variety of methods, 5 including a kinetic method with fluorometry 6 or with spectrophotometry, 7 absorption spectrophotometry, 8 anodic or adsorptive stripping voltammetry, 9 flow constant-current stripping analysis, 10 volatilization separation with inductively coupled plasma optical emission spectrometry (ICPOES), 11 solvent extraction followed by anodic stripping voltammetry, 12 by spectrophotometry, 13,14 by atomic absorption spectrometry (AAS), 15 by hydride generation (HG)/ICPOES, 16 or by inductively coupled plasma mass spectrometry (ICPMS), 17 cloud-point extraction followed by AAS 18 or by ICPOES, 19 polyurethane-foam separation followed by AAS or by neutron activation analysis, 20 solid-phase extraction followed by AAS 21 or by ICPMS, 22 adsorption separation followed by AAS, 23 by HG/AAS, 24 or by ICPOES, 25 column separation using immobilized amino acid followed by HG/ICPOES, 26 HG 27 with AAS, 28,29 with atomic fluorescence spectrometry (AFS), 30 with ICPOES, 31 with ICPMS 32 or with high resolution ICPMS, 33 flow injection with spectrophotometry, 34 with HG/AAS 35 or with HG/AFS, 36 anionexchange chromatography with ICPOES, 37 with ICPMS, [38][39][40] with isotope dilution-ICPMS, 41 with HG/ICPMS, 38 with HG/AAS 38,42 or with HG/AFS, 43 th...…”