Development of a simultaneous PET/Ultrasound imaging system with near real-time reconstruction capability for point-of-care applications

Jiang, Jianyong; Li, Ké; Qi, Bei-Chuan; Komarov, Sergey; OrSullivan, J. A.; Zeng, Yifeng; Wahidi, Ryan; Zhu, Quing; Tai, Yuan‐Chuan

doi:10.1109/nssmic.2017.8532788

Cited by 1 publication

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“…Another class of positron imagers is designed for intra‐operative or endoscopic applications, and although these systems are compact, they have limited three‐dimensional tomographic imaging capability. A compact and versatile PET scanner that can be brought to bedside or a treatment room to support point‐of‐care (POC) imaging applications would be valuable for the deployment of novel molecular theranostic ligands currently under development as well as radiotracers already approved for clinical use …”

Section: Introductionmentioning

confidence: 99%

Feasibility study of a point‐of‐care positron emission tomography system with interactive imaging capability

Jiang

Komarov

et al. 2019

Medical Physics

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Purpose: We investigated the feasibility of a novel positron emission tomography (PET) system that provides near real-time feedback to an operator who can interactively scan a patient to optimize image quality. The system should be compact and mobile to support point-of-care (POC) molecular imaging applications. In this study, we present the key technologies required and discuss the potential benefits of such new capability. Methods: The core of this novel PET technology includes trackable PET detectors and a fully threedimensional, fast image reconstruction engine implemented on multiple graphics processing units (GPUs) to support dynamically changing geometry by calculating the system matrix on-the-fly using a tube-of-response approach. With near real-time image reconstruction capability, a POC-PET system may comprise a maneuverable front PET detector and a second detector panel which can be stationary or moved synchronously with the front detector such that both panels face the region-of-interest (ROI) with the detector trajectory contoured around a patient's body. We built a proof-of-concept prototype using two planar detectors each consisting of a photomultiplier tube (PMT) optically coupled to an array of 48 9 48 lutetium-yttrium oxyorthosilicate (LYSO) crystals (1.0 9 1.0 9 10.0 mm 3 each). Only 38 9 38 crystals in each arrays can be clearly re-solved and used for coincidence detection. One detector was mounted to a robotic arm which can position it at arbitrary locations, and the other detector was mounted on a rotational stage. A cylindrical phantom (102 mm in diameter, 150 mm long) with nine spherical lesions (8:1 tumor-to-background activity concentration ratio) was imaged from 27 sampling angles. List-mode events were reconstructed to form images without or with time-of-flight (TOF) information. We conducted two Monte Carlo simulations using two POC-PET systems. The first one uses the same phantom and detector setup as our experiment, with the detector coincidence re-solving time (CRT) ranging from 100 to 700 ps full-width-at-half-maximum (FWHM). The second study simulates a body-size phantom (316 9 228 9 160 mm 3 ) imaged by a larger POC-PET system that has 4 9 6 modules (32 9 32 LYSO crystals/module, four in axial and six in transaxial directions) in the front panel and 3 9 8 modules (16 9 16 LYSO crystals/module, three in axial and eight in transaxial directions) in the back panel. We also evaluated an interactive scanning strategy by progressively increasing the number of data sets used for image reconstruction. The updated images were analyzed based on the number of data sets and the detector CRT. Results: The proof-of-concept prototype re-solves most of the spherical lesions despite a limited number of coincidence events and incomplete sampling. TOF information reduces artifacts in the reconstructed images. Systems with better timing resolution exhibit improved image quality and reduced artifacts. We observed a reconstruction speed of 0.96 9 10 6 events/s/iteration for 600 9 600 9 224 voxel rect...

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Section: Introductionmentioning

confidence: 99%