The gas-solid separation experiments were conducted to compare separation performance between cyclone separators with different inlet shapes. Besides, the Reynolds stress model was employed to simulate flow field in different cyclones. The results revealed that the cyclone with a trapezoidal inlet could enhance separation efficiency without almost increasing pressure drop. Compared with the conventional rectangular inlet, a trapezoidal inlet had negligible effect on flow field of cyclone's separation space, and it reduced lip flow and upper dust ring of cyclone. In addition, the cyclone with a trapezoidal inlet could improve the inhomogeneous gas flux distribution at the inlet, which was the root reason why secondary flows in cyclone were inhibited and separation efficiency was enhanced.