Development of a triple impinging jet mixer for continuous antisolvent crystallization of acetylsalicylic acid reaction mixture

Tacsi, Kornélia; Joó, Ádám; Pusztai, Éva; Domokos, András; Nagy, Zsombor Kristóf; Marosi, György; Pataki, Hajnalka

doi:10.1016/j.cep.2021.108446

Cited by 18 publications

(3 citation statements)

References 38 publications

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“…In comparison, an impinging jet mixer coupling MSMPR crystallizer under similar conditions yielded only 12.6 g/h. 49 Another result of prolonged ultrasonic action time is the decrease in crystal particle size (Figure 9b), which has also been reported in the literature. 50−52 This phenomenon was attributed to the depolymerization effect of ultrasound.…”

Section: Effect Of Operating Parameters On Continuous Crystallizationsupporting

confidence: 75%

Ultrasonic Enhanced Continuous Crystallization: Induction Time and Process Control

Zhao,

Yang,

Yao

et al. 2023

Ind. Eng. Chem. Res.

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An ultrasound-assisted tube crystallization device was designed for the continuous antisolvent crystallization of acetylsalicylic acid. Both the COMSOL simulation and experimental characterization showed that the designed acoustic crystallizer exhibited high energy efficiency and excellent temperature control. The effects of ultrasonic power, ultrasonic action time, supersaturation degree, and ultrasonic excitation method on the crystallization process were investigated. Due to the intensification of fluid mixing and the introduction of cavitation bubbles as the heterogeneous nucleation sites, the crystallization was significantly enhanced. The induction time of the crystallization was shortened to several hundred milliseconds. The crystallization efficiency could be as high as 80% achieved within 0.46 s. The average particle size of the crystals ranged from 8.2 to 40.1 μm, with a span value of less than 1. Meanwhile, the pulse excitation method can further reduce energy consumption while maintaining the advantages of sonocrystallization. All of these results indicate a far better performance of the present crystallization device than conventional crystallizers, validating the effectiveness of ultrasound promotion. The results also provide insights into optimal operating conditions for ultrasonic crystallization.

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Section: Effect Of Operating Parameters On Continuous Crystallizationsupporting

confidence: 75%

Ultrasonic Enhanced Continuous Crystallization: Induction Time and Process Control

Zhao,

Yang,

Yao

et al. 2023

Ind. Eng. Chem. Res.

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“…Antisolvent crystallization offers superior control over size, morphology and polymorphism of the final crystal, as well as lower energy consumption in supersaturation control [35]. However, scaling up an antisolvent crystallization process is very difficult [36][37][38], as the crystal size depends on the mixing conditions and whether the antisolvent is uniformly incorporated into the solution; hence, several mixing devices have been developed such as T-mixer, confined impinging jet, static mixer, and multi-inlet vortex mixer, to name a few [39][40][41].…”

Section: Antisolvent Crystallization Of Pharmaceuticalsmentioning

confidence: 99%

Recent Progress in Antisolvent Crystallization of Pharmaceuticals with a Focus on the Membrane‐Based Technologies

Haghighizadeh,

Mahdavi,

Rajabi

2024

Chem Eng & Technol

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Continuous crystallization of pharmaceuticals has been in the center of attention during the past two decades, with a more focus on the large‐scale production of active pharmaceutical ingredients. The increasing demand for pharmaceuticals requires high‐throughput production of drug crystals with different solubilities, stabilities, shapes, habits, polymorphs, and size distributions. With numerous advantages including low cost, ease of scale‐up, and superior control over polymorph and size distribution of drug crystals, antisolvent crystallization is one of the most promising crystallization methods recently attempted. However, it fails to deliver the required characteristic where the crystal systems tend to grow and for the preparation of metastable polymorphs. This review focuses on the most recent efforts to tackle these drawbacks by coupling antisolvent crystallization with cooling, supercritical‐assisted, microfluidics‐assisted, and membrane‐assisted crystallization. This systematic review aims to provide a concise summary of each coupled antisolvent technique and their positive and negative aspects. This review can be used as a guideline for pharmacist, biologists, and chemists, who are interested in the crystal engineering of pharmaceuticals to pave the way for further developments in this field.

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“…Their fouling resistance (for fast reactions) and excellent mixing characteristics have led to their recent emergence in continuous micro/nanoparticle synthesis. 131,132 In a typical jet reactor at least two liquid jet streams are introduced at high velocities in a mixing zone, where their kinetic energy is converted into chaotic motion through impinging or redirecting the flow in a course of a small volume. 133 The impinged liquid jets mix rapidly 35,134 (within 0.2-10 ms), making jet reactors ideal candidates when the timescales for nanoparticle formation are ≪1 s.…”

Section: Jet Reactorsmentioning

confidence: 99%

Non-fouling flow reactors for nanomaterial synthesis

et al. 2023

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Development of a triple impinging jet mixer for continuous antisolvent crystallization of acetylsalicylic acid reaction mixture

Cited by 18 publications

References 38 publications

Ultrasonic Enhanced Continuous Crystallization: Induction Time and Process Control

Ultrasonic Enhanced Continuous Crystallization: Induction Time and Process Control

Recent Progress in Antisolvent Crystallization of Pharmaceuticals with a Focus on the Membrane‐Based Technologies

Non-fouling flow reactors for nanomaterial synthesis

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