Development of a twice daily dosing regimen of amoxicillin/clavulanate

Bax, Richard

doi:10.1016/j.ijantimicag.2007.09.002

Cited by 21 publications

(17 citation statements)

References 11 publications

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“…While the 625 mg t.i.d. dose of amoxicillin has a better time above MIC pharmacokinetic/pharmacodynamic profile [51], there is no established superiority for this dose versus the 875 mg b.i.d. dose administered in the current study.…”

Section: Discussionmentioning

confidence: 99%

Moxifloxacinversusamoxicillin/clavulanic acid in outpatient acute exacerbations of COPD: MAESTRAL results

et al. 2011

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Bacterial infections causing acute exacerbations of chronic obstructive pulmonary disease (AECOPD) frequently require antibacterial treatment. More evidence is needed to guide antibiotic choice.The Moxifloxacin in Acute Exacerbations of Chronic Bronchitis TriaL (MAESTRAL) was a multiregional, randomised, double-blind non-inferiority outpatient study. Patients were aged ≥60 yrs, with an Anthonisen type I exacerbation, a forced expiratory volume in 1 s <60% predicted and two or more exacerbations in the last year. Following stratification by steroid use patients received moxifloxacin 400 mg p.o. q.d. (5 days) or amoxicillin/clavulanic acid 875/125 mg p.o. b.i.d. (7 days). The primary end-point was clinical failure 8 weeks post-therapy in the per protocol population.Moxifloxacin was noninferior to amoxicillin/clavulanic acid at the primary end-point (111 (20.6%) out of 538, versus 114 (22.0%) out of 518, respectively; 95% CI -5.89–3.83%). In patients with confirmed bacterial AECOPD, moxifloxacin led to significantly lower clinical failure rates than amoxicillin/clavulanic acid (in the intent-to-treat with pathogens, 62 (19.0%) out of 327 versus 85 (25.4%) out of 335, respectively; p=0.016). Confirmed bacterial eradication at end of therapy was associated with higher clinical cure rates at 8 weeks post-therapy overall (p=0.0014) and for moxifloxacin (p=0.003). Patients treated with oral corticosteroids had more severe disease and higher failure rates.The MAESTRAL study showed that moxifloxacin was as effective as amoxicillin/clavulanic acid in the treatment of outpatients with AECOPD. Both therapies were well tolerated.

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Section: Discussionmentioning

confidence: 99%

Moxifloxacinversusamoxicillin/clavulanic acid in outpatient acute exacerbations of COPD: MAESTRAL results

et al. 2011

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“…Indeed, in some studies, patients improved after 2 or 3 days of antibiotic therapy 31,35–37. In general, reducing the frequency of antibiotic intake (without compromising the dose) has yielded improved results: a twice-daily dosage of amoxicillin/clavulanate had several advantages over the three times-daily dosage, including increased convenience, improved compliance, and improved tolerability 38,39…”

Section: Therapeutic Antibiotic Prescribing By Dentistsmentioning

confidence: 99%

“…Prolonged courses of antibiotics destroy the commensal flora 38. In addition, longer durations of up to 21 days may result in the selection of resistant strains and a reduction in the ability of the oral flora to resist the colonization by harmful micro-organisms that are not normal residents,42 leading to superimposed infections by multi-resistant bacteria and yeasts 15…”

Section: Therapeutic Antibiotic Prescribing By Dentistsmentioning

confidence: 99%

Antibiotic prescribing practices by dentists: a review

Dar‐Odeh

Abu‐Hammad²,

AL‐Omiri³

et al. 2010

TCRM

214

251

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Antibiotics are prescribed by dentists for treatment as well as prevention of infection. Indications for the use of systemic antibiotics in dentistry are limited, since most dental and periodontal diseases are best managed by operative intervention and oral hygiene measures. However, the literature provides evidence of inadequate prescribing practices by dentists, due to a number of factors ranging from inadequate knowledge to social factors. Here we review studies that investigated the pattern of antibiotic use by dentists worldwide. The main defects in the knowledge of antibiotic prescribing are outlined. The main conclusion is that, unfortunately, the prescribing practices of dentists are inadequate and this is manifested by over-prescribing. Recommendations to improve antibiotic prescribing practices are presented in an attempt to curb the increasing incidence of antibiotic resistance and other side effects of antibiotic abuse.

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“…Supporting evidence, indicate that antibiotics are of no additional benefit. 12 This amounts for overuse of antibiotics as per our survey results.…”

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confidence: 75%

“…32,33,34,35 There are several advantages of short course therapy: increased convenience, improved compliance, and improved tolerability. 12,36 Unfortunately, a false conception about the use of antibiotics is that antibiotics should be used for a certain number of days. Antibiotics should be used aggressively and for as short period as is compatible with patient remission of diseases.…”

mentioning

confidence: 99%