Development of a Two-Way Coupled Eulerian–Lagrangian Computational Magnetic Nanoparticle Targeting Model for Pulsatile Flow in a Patient-Specific Diseased Left Carotid Bifurcation Artery

Hewlin, Rodward L.; Ciero, Ashley; Kizito, John P.

doi:10.1007/s13239-019-00411-8

Cited by 22 publications

(10 citation statements)

References 33 publications

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“…After the initial selection of the form of the platform, computational modeling can be used to simulate the kinetics of NO delivery, so as to obtain significant guidance for the optimized design of spatiotemporal delivery strategy to the expected target and improve the delivery efficiency. Taking nanoparticles as an example, the complex hemodynamic environment around a target tissue affects whether they can reach the target tissue at an expected dose and thus play their expected role [134,135]. By analyzing the blood flow topology, researchers have simulated a WSS-sensitive drug delivery system based on nanoparticle drugs, which may help to improve drug efficacy [136].…”

Section: Combining Controllable No Release Platform With Computational Modeling To Manipulate No Delivery Processmentioning

confidence: 99%

Delivery of Nitric Oxide in the Cardiovascular System: Implications for Clinical Diagnosis and Therapy

Zhang

Chen

et al. 2021

IJMS

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Nitric oxide (NO) is a key molecule in cardiovascular homeostasis and its abnormal delivery is highly associated with the occurrence and development of cardiovascular disease (CVD). The assessment and manipulation of NO delivery is crucial to the diagnosis and therapy of CVD, such as endothelial dysfunction, atherosclerotic progression, pulmonary hypertension, and cardiovascular manifestations of coronavirus (COVID-19). However, due to the low concentration and fast reaction characteristics of NO in the cardiovascular system, clinical applications centered on NO delivery are challenging. In this tutorial review, we first summarized the methods to estimate the in vivo NO delivery process, based on computational modeling and flow-mediated dilation, to assess endothelial function and vulnerability of atherosclerotic plaque. Then, emerging bioimaging technologies that have the potential to experimentally measure arterial NO concentration were discussed, including Raman spectroscopy and electrochemical sensors. In addition to diagnostic methods, therapies aimed at controlling NO delivery to regulate CVD were reviewed, including the NO release platform to treat endothelial dysfunction and atherosclerosis and inhaled NO therapy to treat pulmonary hypertension and COVID-19. Two potential methods to improve the effectiveness of existing NO therapy were also discussed, including the combination of NO release platform and computational modeling, and stem cell therapy, which currently remains at the laboratory stage but has clinical potential for the treatment of CVD.

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Section: Combining Controllable No Release Platform With Computational Modeling To Manipulate No Delivery Processmentioning

confidence: 99%

Delivery of Nitric Oxide in the Cardiovascular System: Implications for Clinical Diagnosis and Therapy

Zhang

Chen

et al. 2021

IJMS

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show abstract

“…After the initial selection of the form of the platform, numerical simulation can be used to simulate the kinetics of the NO delivery, so as to get significant guidance for an optimized design of spatiotemporal delivery strategy to the expected target and improve delivery efficiency. Taking nanoparticle as an example, the complex hemodynamic environment around the target tissue affects whether it can reach the target tissue at the expected dose and thus play the expected role [162,163]. By analyzing the blood flow topology, researchers simulated the WSS-sensitive drug delivery system based on the nanoparticle drugs, which may help to improve drug efficacy [164].…”

Section: The Manipulation Of No Delivery With No Releasing Platformmentioning

confidence: 99%

The Delivery of Nitric Oxide in the Cardiovascular System: Implication for Clinical Diagnosis and Therapy

Ma¹,

Zhang²,

Chen³

et al. 2021

Preprint

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Nitric oxide (NO) is a key molecule in cardiovascular homeostasis and its abnormal delivery is highly associated with the occurrence and development of cardiovascular disease (CVD). The assessment and manipulation of NO delivery is crucial to the diagnosis and therapy of CVD, such as endothelial dysfunction, atherosclerotic progression, pulmonary hypertension, and cardiovascular manifestations of Coronavirus (COVID-19). However, due to the low concentration and fast reaction characteristics of NO in cardiovascular system, the clinical applications centered on the NO delivery are challenging. In this tutorial review, we first summarized the methods to estimate the in vivo NO delivery process based on the clinical images and mathematical modeling to assess the endothelial function and vulnerability of atherosclerotic plaque. Then, the emerging bioimaging technologies that have the potential to directly measure the arterial NO concentration were discussed, including the Raman spectroscopy and electrochemical sensor. Aside from the diagnostic methods, therapies aimed at controlling NO delivery to regulate CVD were reviewed, including the inhaled NO therapy to treat the pulmonary hypertension and COVID-19, stem cell therapy and NO-releasing platform to treat endothelial dysfunction and atherosclerosis.

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“…Immunolabeling, magnetic bead separation, and laminar flow-based separation are some of the most common techniques utilized in LOC applications. In addition to current methods for cellular manipulation at the micro-scale, methods based on magnetic bead targeting have been investigated at the macroscale level in computational and experimental work for potential medical drug targeting [ 9 , 10 ]. On the micro-scale level, separation methods based on magnetic beads require labeling, as well as multiple and prolonged incubation and wash cycles.…”

Section: Introductionmentioning

confidence: 99%

Continuous Flow Separation of Red Blood Cells and Platelets in a Y-Microfluidic Channel Device with Saw-Tooth Profile Electrodes via Low Voltage Dielectrophoresis

Hewlin

Edwards

2023

CIMB

Self Cite

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Cell counting and sorting is a vital step in the purification process within the area of biomedical research. It has been widely reported and accepted that the use of hydrodynamic focusing in conjunction with the application of a dielectrophoretic (DEP) force allows efficient separation of biological entities such as platelets from red blood cell (RBC) samples due to their size difference. This paper presents computational results of a multiphysics simulation modelling study on evaluating continuous separation of RBCs and platelets in a microfluidic device design with saw-tooth profile electrodes via DEP. The theoretical cell particle trajectory, particle cell counting, and particle separation distance study results reported in this work were predicted using COMSOL v6.0 Multiphysics simulation software. To validate the numerical model used in this work for the reported device design, we first developed a simple y-channel microfluidic device with square “in fluid” electrodes similar to the design reported previously in other works. We then compared the obtained simulation results for the simple y-channel device with the square in fluid electrodes to the reported experimental work done on this simple design which resulted in 98% agreement. The design reported in this work is an improvement over existing designs in that it can perform rapid separation of RBCs (estimated 99% purification) and platelets in a total time of 6–7 s at a minimum voltage setting of 1 V and at a minimum frequency of 1 Hz. The threshold for efficient separation of cells ends at 1000 kHz for a 1 V setting. The saw-tooth electrode profile appears to be an improvement over existing designs in that the sharp corners reduced the required horizontal distance needed for separation to occur and contributed to a non-uniform DEP electric field. The results of this simulation study further suggest that this DEP separation technique may potentially be applied to improve the efficiency of separation processes of biological sample scenarios and simultaneously increase the accuracy of diagnostic processes via cell counting and sorting.

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Development of a Two-Way Coupled Eulerian–Lagrangian Computational Magnetic Nanoparticle Targeting Model for Pulsatile Flow in a Patient-Specific Diseased Left Carotid Bifurcation Artery

Cited by 22 publications

References 33 publications

Delivery of Nitric Oxide in the Cardiovascular System: Implications for Clinical Diagnosis and Therapy

Delivery of Nitric Oxide in the Cardiovascular System: Implications for Clinical Diagnosis and Therapy

The Delivery of Nitric Oxide in the Cardiovascular System: Implication for Clinical Diagnosis and Therapy

Continuous Flow Separation of Red Blood Cells and Platelets in a Y-Microfluidic Channel Device with Saw-Tooth Profile Electrodes via Low Voltage Dielectrophoresis

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