Development of a vertically and horizontally applicable multi-frequency alternating-magnetic-field device for hyperthermia of glioma in rodent model using iron oxide based nanoparticles

Piao, Daqing; Le, Kelvin; Saunders, Debra; Smith, Nataliya; Goddard, Jessica; Figueroa, Daniel; Krasiński, Jerzy S.; Chen, Wei R.; Towner, Rheal A.

doi:10.1364/biomed.2012.bsu3a.2

Cited by 4 publications

(6 citation statements)

References 6 publications

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“…Similarly, a solenoid coil of 60 mm height, 50 mm diameter and 25 turns was described by Cano et al [14] and the maximum magnetic flux intensity reached 150 Gs. Piao et al [15] reported an induction heater that could heat samples both in vertical and in horizontal orientations and used a solenoid coil of 60 mm height and 40 mm inner diameter to generate a magnetic field of 220 Gs and 156 kHz. These devices were mainly designed for vitro and small animal experiments, but were inappropriate in the cases of large animal or clinical applications.…”

Section: Z Wu Et Al / An Induction Heating Device Using Planar Coilmentioning

confidence: 99%

An induction heating device using planar coil with high amplitude alternating magnetic fields for magnetic hyperthermia

Wu¹,

Zhuo

Cai³

et al. 2015

THC

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Abstract. BACKGROUND: Induction heating devices using the induction coil and magnetic nanoparticles (MNPs) are the way that the magnetic hyperthermia is heading. OBJECTIVE: To facilitate the induction heating of in vivo magnetic nanoparticles in hyperthermia experiments on large animals. METHODS: An induction heating device using a planar coil was designed with a magnetic field frequency of 328 kHz. The coil's magnetic field distribution and the device's induction heating performance on different concentrations of magnetic nanoparticles were measured. RESULTS: The alternating magnetic field produced in the axis position 165 mm away from the coil center is 40 Gs in amplitude; magnetic nanoparticles with a concentration higher than 80 mg. mL −1 can be heated up rapidly. CONCLUSION: Our results demonstrate that the device can be applied not only to in vitro and in small animal experiments of magnetic hyperthermia using MNPs, but also in large animal experiments.

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Section: Z Wu Et Al / An Induction Heating Device Using Planar Coilmentioning

confidence: 99%

An induction heating device using planar coil with high amplitude alternating magnetic fields for magnetic hyperthermia

Wu¹,

Zhuo

Cai³

et al. 2015

THC

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“…28 The AMF device, of which the schematic is shown in Fig. 2(a) and the photograph of the coil part is shown in Fig.…”

Section: Iiia a Continuous Wave Amf System For Spion Based Hyperthementioning

confidence: 99%

“…A continuous wave AMF system has been developed for therapeutic evaluation of hyperthermia induced by SPION. 28 The AMF device, of which the schematic is shown in Fig. 2(a) and the photograph of the coil part is shown in Fig.…”

Section: Iiia a Continuous Wave Amf System For Spion Based Hyperthementioning

confidence: 99%

Magnetothermoacoustics from magnetic nanoparticles by short bursting or frequency chirped alternating magnetic field: A theoretical feasibility analysis

et al. 2013

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Purpose:To propose an alternative method of thermoacoustic wave generation based on heating of magnetic nanoparticles (MNPs) using alternating magnetic field (AMF). Methods: The feasibility of thermoacoustic wave generation from MNPs by applying a short-burst of AMF or a frequency-modulated AMF is theoretically analyzed. As the relaxation of MNPs is strongly dependent upon the amplitude and frequency of AMF, either an amplitude modulated, fixed frequency AMF (termed time-domain AMF) or a frequency modulated, constant amplitude AMF (termed frequency-domain AMF) will result in time-varying heat dissipation from MNPs, which has the potential to generate thermoacoustic waves. Following Rosensweig's model of specific power loss of MNPs in a steady-state AMF, the time-resolved heat dissipations of MNPs of superparamagnetic size when exposed to a short bursting of AMF and/or to a linearly frequency chirped AMF are derived, and the resulted acoustic propagation is presented. Based on experimentally measured temperaturerise characteristics of a superparamagnetic iron-oxide nanoparticle (SPION) matrix in a steady-state AMF of various frequencies, the heat dissipations of the SPION under time-domain and frequencydomain AMF configurations that could have practical utility for thermoacoustic wave generation are estimated. Results:The initial rates of the temperature-rise of the SPION matrix were measured at an ironweight concentration of 0.8 mg/ml and an AMF frequency of 88.8 kHz to 1.105 MHz. The measured initial rates of temperature-rise were modeled by Rosensweig's theory, and projected to 10 MHz AMF frequency, at which a 1 μs bursting corresponding to a 1.55 mm axial resolution of acoustic detection could contain 10 complete cycles of AMF oscillation and the power dissipation is approximately 84 times of that at 1 MHz. Exposing the SPION matrix to a 1 μs bursting of AMF at 10 MHz frequency and 100 Oe field intensity would produce a volumetric heat dissipation of 7.7 μJ/cm 3 over the microsecond duration of the AMF burst. If the SPION matrix is exposed to a 1 ms long AMF train at 100 Oe field intensity that chirps linearly from 1 to 10 MHz, the volumetric heat dissipation produced over each 2π phase change of the AMF oscillation is estimated to increase from 0.15 to 1.1 μJ/cm 3 within the millisecond duration of the chirping of AMF. Conclusions: The heat dissipations upon SPION (∼1 mg/ml iron-weight concentration) by a 1 μs bursting of 100 Oe AMF at 10 MHz and a 1 ms train of 100 Oe AMF that chirps linearly from 1 to 10 MHz were estimated to determine the potential of thermal-acoustic wave generation. Although thermoacoustic wave generation from MNPs by time-or frequency-domain AMF applications is predicted, the experimental generation of such a wave remains challenging. © 2013 American Association of Physicists in Medicine. [http://dx

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“…Conversely, for single domain particles with diameters lower than 40 nm, so-called super-paramagnetic iron-oxide nanoparticles (SPION), Brownian and Néel relaxations are the main mechanisms of heat conversion for AMF frequency above 100 KHz. Finally, for smaller iron-oxide nanoparticles (~10 nm), Néel relaxation becomes the dominant mechanism at the AMF frequencies typical of hyperthermia studies [ 6 , 7 ].…”

Section: Biomedical Applications Exploiting Magnetic Fieldmentioning

confidence: 99%

“…Brown relaxation governs the reorientation of the magnetic particle itself in a fluid, resulting in friction between the particle and the fluid. Instead, Néel relaxation derives from the magnetic moment reorientation within the particles, in opposition to the anisotropy energy that tends to orient the magnetic domain towards a given direction with respect to the crystal lattice [ 6 , 9 ]. As the magnetic field excitation frequency increases, the nanoparticles’ magnetic moments accumulate a phase lag with respect to the applied field.…”

Section: Biomedical Applications Exploiting Magnetic Fieldmentioning

confidence: 99%

Shaping and Focusing Magnetic Field in the Human Body: State-of-the Art and Promising Technologies

Rotundo

Brizi

Flori

et al. 2022

Sensors

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In recent years, the usage of radio frequency magnetic fields for biomedical applications has increased exponentially. Several diagnostic and therapeutic methodologies exploit this physical entity such as, for instance, magnetic resonance imaging, hyperthermia with magnetic nanoparticles and transcranial magnetic stimulation. Within this framework, the magnetic field focusing and shaping, at different depths inside the tissue, emerges as one of the most important challenges from a technological point of view, since it is highly desirable for improving the effectiveness of clinical methodologies. In this review paper, we will first report some of the biomedical practices employing radio frequency magnetic fields, that appear most promising in clinical settings, explaining the underneath physical principles and operative procedures. Specifically, we direct the interest toward hyperthermia with magnetic nanoparticles and transcranial magnetic stimulation, together with a brief mention of magnetic resonance imaging. Additionally, we deeply review the technological solutions that have appeared so far in the literature to shape and control the radio frequency magnetic field distribution within biological tissues, highlighting human applications. In particular, volume and surface coils, together with the recent raise of metamaterials and metasurfaces will be reported. The present review manuscript can be useful to fill the actual gap in the literature and to serve as a guide for the physicians and engineers working in these fields.

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Development of a vertically and horizontally applicable multi-frequency alternating-magnetic-field device for hyperthermia of glioma in rodent model using iron oxide based nanoparticles

Cited by 4 publications

References 6 publications

An induction heating device using planar coil with high amplitude alternating magnetic fields for magnetic hyperthermia

An induction heating device using planar coil with high amplitude alternating magnetic fields for magnetic hyperthermia

Magnetothermoacoustics from magnetic nanoparticles by short bursting or frequency chirped alternating magnetic field: A theoretical feasibility analysis

Shaping and Focusing Magnetic Field in the Human Body: State-of-the Art and Promising Technologies

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