Development of a w/o emulsion using ionic liquid strategy for transdermal delivery of anti – aging component α – lipoic acid: Mechanism of different ionic liquids on skin retention and efficacy evaluation

Zhou, Zhuang; Liu, Chao; Wan, Xiaocao; Fang, Liang

doi:10.1016/j.ejps.2019.105042

Cited by 28 publications

(19 citation statements)

References 57 publications

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“…The lamellar structure of GMS is similar to the structure of the human stratum corneum; therefore, the hydrated lamellar phase could significantly increase the water content of the stratum corneum [ 32 , 33 ]. There is much evidence that hydration induces a significant increase in drug permeability [ 34 , 35 , 36 ]. The concept of self-emulsifying drug delivery systems (SEDDSs) was pioneered in the 1960s, when components of poor aqueous solubility were incorporated into mixtures of lipophilic and hydrophilic excipients to enhance the solubility of lipophilic substances [ 37 ].…”

Section: Introductionmentioning

confidence: 99%

Preparation and In Vivo Evaluation of a Lidocaine Self-Nanoemulsifying Ointment with Glycerol Monostearate for Local Delivery

et al. 2021

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Lidocaine, a commonly used local anesthetic, has recently been developed into a number of ointment products to treat hemorrhoids. This study examined its efficient delivery to the dermis through the pharmaceutical improvement of hemorrhoid treatment ointments. We attempted to increase the amount of skin deposition of lidocaine by forming a nanoemulsion through the self-nanoemulsifying effect that occurs when glycerol monostearate (GMS) is saturated with water. Using Raman mapping, the depth of penetration of lidocaine was visualized and confirmed, and the local anesthetic effect was evaluated via an in vivo tail-flick test. Evaluation of the physicochemical properties confirmed that lidocaine was amorphous and evenly dispersed in the ointment. The in vitro dissolution test confirmed that the nanoemulsifying effect of GMS accelerated the release of the drug from the ointment. At a specific concentration of GMS, lidocaine penetrated deeper into the dermis; the in vitro permeation test showed similar results. When compared with reference product A in the tail-flick test, the L5 and L6 compounds containing GMS had a significantly higher anesthetic effect. Altogether, the self-nanoemulsifying effect of GMS accelerated the release of lidocaine from the ointment. The compound with 5% GMS, the lowest concentration that saturated the dermis, was deemed most appropriate.

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Section: Introductionmentioning

confidence: 99%

Preparation and In Vivo Evaluation of a Lidocaine Self-Nanoemulsifying Ointment with Glycerol Monostearate for Local Delivery

et al. 2021

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“…In this area, a pre-existing—and current—literature has focused on the role of mitochondria in creating a prooxidant state since the early studies [ 78 , 79 ]. Hence, a line of studies has pursued MN-containing preparations [ 80 , 81 ], and a body of literature has reported the favorable effects of topical MN administration using ALA [ 82 , 83 ] or CoQ10 [ 84 , 85 ] or CARN [ 86 ], as evaluated in clinical trials. In several studies, MN administration was accompanied by other ingredients.…”

Section: Mitochondrial Nutrient-based Clinical Trials In Aging-relmentioning

confidence: 99%

Aging-Related Disorders and Mitochondrial Dysfunction: A Critical Review for Prospect Mitoprotective Strategies Based on Mitochondrial Nutrient Mixtures

Pagano

Pallardó

Lyakhovich

et al. 2020

IJMS

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A number of aging-related disorders (ARD) have been related to oxidative stress (OS) and mitochondrial dysfunction (MDF) in a well-established body of literature. Most studies focused on cardiovascular disorders (CVD), type 2 diabetes (T2D), and neurodegenerative disorders. Counteracting OS and MDF has been envisaged to improve the clinical management of ARD, and major roles have been assigned to three mitochondrial cofactors, also termed mitochondrial nutrients (MNs), i.e., α-lipoic acid (ALA), Coenzyme Q10 (CoQ10), and carnitine (CARN). These cofactors exert essential–and distinct—roles in mitochondrial machineries, along with strong antioxidant properties. Clinical trials have mostly relied on the use of only one MN to ARD-affected patients as, e.g., in the case of CoQ10 in CVD, or of ALA in T2D, possibly with the addition of other antioxidants. Only a few clinical and pre-clinical studies reported on the administration of two MNs, with beneficial outcomes, while no available studies reported on the combined administration of three MNs. Based on the literature also from pre-clinical studies, the present review is to recommend the design of clinical trials based on combinations of the three MNs.

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“…It has been verified to have active oxygen scavenging effect and anti-inflammatory properties [3][4][5]. As an antioxidant, it can be effective in many fields, such as vitamin supplements for therapeutic drugs, health foods and anti-aging beauty products [6][7][8][9]. Alpha-lipoic acid has good physicochemical properties for transdermal administration, but its hydrophobicity and extreme vulnerability to degradation by the sunlight limit its application [10,11].…”

Section: Introductionmentioning

confidence: 99%

PEG-interpenetrated genipin-crosslinked dual-sensitive hydrogel/nanostructured lipid carrier compound formulation for topical drug administration

Gong

Yao

et al. 2021

Artificial Cells, Nanomedicine, and Biotechnology

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Development of a w/o emulsion using ionic liquid strategy for transdermal delivery of anti – aging component α – lipoic acid: Mechanism of different ionic liquids on skin retention and efficacy evaluation

Cited by 28 publications

References 57 publications

Preparation and In Vivo Evaluation of a Lidocaine Self-Nanoemulsifying Ointment with Glycerol Monostearate for Local Delivery

Preparation and In Vivo Evaluation of a Lidocaine Self-Nanoemulsifying Ointment with Glycerol Monostearate for Local Delivery

Aging-Related Disorders and Mitochondrial Dysfunction: A Critical Review for Prospect Mitoprotective Strategies Based on Mitochondrial Nutrient Mixtures

PEG-interpenetrated genipin-crosslinked dual-sensitive hydrogel/nanostructured lipid carrier compound formulation for topical drug administration

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