Development of abamectin‐loaded nanoemulsion and its insecticidal activity and cytotoxicity

Feng, Jianguo; Chen, Wang; Liu, Qi; Chen, Ziyang; Yang, Jinghan; Yang, Wenchao

doi:10.1002/ps.5976

Cited by 39 publications

(15 citation statements)

References 51 publications

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“…All nanoemulsions were prepared by a low-energy emulsification method at 25 °C. 30 Pyriproxyfen (5%) and emulsifier (6%) were dissolved in solvent naphtha S-100 (5%) to form the oil phase, and the aqueous phase (deionized water) was then added dropwise to the oil phase on a magnetic stirrer. The resulting mixture was stirred at 1000 rpm for 18 min to form a nanoemulsion.…”

Section: ■ Introductionmentioning

confidence: 99%

Development and Characterization of Pyriproxyfen-Loaded Nanoemulsion for Housefly Control: Improving Activity, Reducing Toxicity, and Protecting Ecological Environment

Feng

Chen

et al. 2021

ACS Sustainable Chem. Eng.

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Nanoemulsion provides an effective way for the efficient, safe, and environmentally friendly use for pesticides. In this study, the influence of the type, dosage of emulsifier, and emulsifying process on the formation and stability of nanoemulsion were investigated. On this basis, the optimal nanoemulsion formula loaded with pyriproxyfen was obtained. Pyriproxyfen (5%) and polyoxyethylene castor oil ether (6%; EL-20) were dissolved in hydrocarbon solvent (5%; S-100) with deionized water replenished to 100%. Compared with oil-in-water emulsion (EW) and emulsifiable concentrate (EC), the longest drying time ensured that the nanoemulsions had a more durable control effect. The pyriproxyfen-loaded nanoemulsions had a high pupation inhibition rate and 100% eclosion inhibition rate. In addition, at 7 and 14 days, the 50% lethal concentrations (LC 50 ) of pyriproxyfen-loaded nanoemulsions to Eisenia fetida were 1450.63 and 804.19 mg/kg, respectively, indicating their low acute toxicity to earthworms and environmental friendliness. Moreover, the pyriproxyfen-loaded nanoemulsions showed a low apoptosis rate (5.29%), whose value was considerably lower than that of EW (29.51%) and EC (9.45%), indicating a low toxicity to human hepatocyte L02 cells. This research facilitated the design and fabrication of nanoemulsions for water-insoluble pesticides to enhance the insecticidal activity, lower the cytotoxicity, and reduce environmental pollution of such chemicals.

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Section: ■ Introductionmentioning

confidence: 99%

Development and Characterization of Pyriproxyfen-Loaded Nanoemulsion for Housefly Control: Improving Activity, Reducing Toxicity, and Protecting Ecological Environment

Feng

Chen

et al. 2021

ACS Sustainable Chem. Eng.

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“…Visual injury assessment indicated that the nano-emulsion formulations showed significantly lower effective dose 50 (ED 50 ) than Roundup ® , suggesting that they exhibited higher biological efficacy. In another study, Feng et al developed an abamectin (Abm)-loaded nano-emulsion containing 2% Abm, 5% castor oil polyoxyethylene, and 7.5% hydrocarbon solvent, which conformed to the quality indicators of the Food and Agriculture Organization (FAO) [86]. Compared with commercial oil/water emulsions (EW) and microemulsions (ME), the nano-emulsion exhibited various advantages such as a smaller dynamic contact angle on cabbage leaves, higher insecticidal activity, and lower cytotoxicity.…”

Section: Nano-emulsionmentioning

confidence: 99%

Conventional agrochemicals towards nano-biopesticides: an overview on recent advances

Abdollahdokht

Gao

Faramarz

et al. 2022

Chem. Biol. Technol. Agric.

107

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Pesticides are classified into several groups based on their structure, including fungicides, insecticides, herbicides, bactericides, and rodenticides. Pesticides are toxic to both humans and pests. For pest control, a very small amount of pesticides reach their target pests. Therefore, nearly all pesticides move through the environment and exert adverse effects on beneficial biota and public health. These chemicals pollute the water, soil, and atmosphere of the ecosystem. Agricultural workers in greenhouses and open fields, exterminators of house pests, and workers in the pesticide industry are occupationally exposed to pesticides. Pesticide exposure in the general population primarily happens through the consumption of food and water contaminated with pesticide residues; however, substantial exposure can also occur outside or inside the house. Currently, intelligent, responsive, biodegradable, and biocompatible materials have attracted considerable interest for the formulation of green, safe, and efficient pesticides. It was indicated that utilizing nanotechnology to design and prepare targeted pesticides with an environmentally responsive controlled release via chemical modifications and compounds offers great potential for creating new formulations. Furthermore, biopesticides include microbial pesticides, which are naturally happening biochemical pesticides. In addition, pesticidal substances generated by plants with added genetic materials, i.e., plant-incorporated protectants (PIPs), have emerged. Based on the foregoing evidence, various types of pesticides are summarized in this review for the first time. Here, new pesticides including nano-pesticides and biopesticides are discussed while focusing on the most recent findings on targeted and safe nano-formulated biopesticides and nano-pesticides. Graphical Abstract

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“…An appropriate emulsifier plays an important role in the preparation of stable nanoemulsions 31,32 . As an essential trait of emulsifiers, HLB value is an important basis for selecting emulsifiers for nanoemulsions 33,34 .…”

Section: Influence Of Emulsifier Type On the Stability Of The Citrone...mentioning

confidence: 99%

Citronella Oil Nanoemulsion: Formulation, Characterization, Antibacterial Activity, and Cytotoxicity

Chen¹,

Tang²,

Lu³

et al. 2022

Acta Physico Chimica Sinica

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The excessive and unreasonable use of synthetic bactericides in the agricultural field has caused many serious problems, including toxic effects on human health and environmental pollution. Therefore, searching for low toxicity, highly efficient, and no-residue natural bactericides is urgently needed. Plant essential oil has become an emerging and hot topic in the agricultural field because of its excellent bactericidal activity, good biocompatibility, and abundant sources. Citronella oil is a natural plant essential oil with insect repellent, insecticidal, and antibacterial activities, which mainly includes citronellal, geraniol, and citronellol. At present, the major of research on citronella oil focuses on the repellency and control of sanitary pests, but there are relatively few reports on the control of agricultural pathogenic bacteria. In addition, the hydrophobicity and volatility of citronella oil lead to its low bioavailability and hinder its full biological activity. Therefore, constructing a delivery system for improving the hydrophobicity and reducing the volatility of citronella oil is urgently needed. Nanoemulsions have the advantages of fine and uniform droplets, better physical stability, efficient permeation ability, and enhanced bioavailability. Therefore, nanoemulsions are important drug delivery systems for hydrophobic pesticides. In this study, the influences of emulsifier type (hydrophilic-lipophilic balance (HLB)), dosage, and emulsifying time on the formation and stability of citronella oil nanoemulsions were investigated by observing the appearances and microstructures of samples and measuring droplet size, thereby the optimized formula of the citronella oil nanoemulsions was determined. Furthermore, the bioactivity and biosafety of citronella oil nanoemulsions were also investigated. The results showed that nanoemulsions using castor oil polyoxyethylene ethers EL-40 (hydrophilic-lipophilic balance = 13.5) as an emulsifier had the best performance, and the stability of nanoemulsions improved as the emulsifier dosage increased from 3% to 7% (w, mass fraction). In addition, the nanoemulsion prepared through high speed shearing for 3 min was the most stable. The optimal formula for citronella oil nanoemulsions was determined to contain 5% (w) citronella oil, 6% (w) emulsifier (EL-40), and 89% (w) deionized water, upon high speed shearing for 3 min. Then, the inhibitory effect of citronella oil nanoemulsions against the growth of Pantoea ananatis was studied. The concentration for 50% of maximal effect (EC50) of citronella oil nanoemulsions against Pantoea ananatis was 74.85 mg•L −1 . The cell viability of L02 cells treated with the citronella oil nanoemulsions (below 100 mg•L −1 ) was above 83% after 24 h, and the apoptosis rate was 6.93%, indicating that the citronella oil nanoemulsions had low cytotoxicity. This research facilitated the design and fabrication of stable, efficient, and safe agricultural nanoemulsions, and it provides a practical solution for using plant essential oils as ag...

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Development of abamectin‐loaded nanoemulsion and its insecticidal activity and cytotoxicity

Cited by 39 publications

References 51 publications

Development and Characterization of Pyriproxyfen-Loaded Nanoemulsion for Housefly Control: Improving Activity, Reducing Toxicity, and Protecting Ecological Environment

Development and Characterization of Pyriproxyfen-Loaded Nanoemulsion for Housefly Control: Improving Activity, Reducing Toxicity, and Protecting Ecological Environment

Conventional agrochemicals towards nano-biopesticides: an overview on recent advances

Citronella Oil Nanoemulsion: Formulation, Characterization, Antibacterial Activity, and Cytotoxicity

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