Development of (acrylic acid/ polyethylene glycol)-zinc oxide mucoadhesive nanocomposites for buccal administration of propranolol HCl

Mahmoud, Ghada A.; Ali, Amr El‐Hag; Raafat, Amany I.; Badawy, Nagwa A.; Elshahawy, M. F.

doi:10.1016/j.radphyschem.2018.01.020

Cited by 24 publications

(5 citation statements)

References 52 publications

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“…Being safe and cost effective, ZnO NPs are among the most commonly used NPs (Jiang, Pi, & Cai, 2018;Siddiqi, Rahman, Husen, & Husen, 2018). They exert their antimicrobial activity via several mechanisms including: binding to membranes; disrupting their potential and integrity, inducing ROS production and their positive charges enhance destruction of organic material upon direct contact (Bondarenko et al, 2018;Mahmoud, Ali, Raafat, Badawy, & Elshahawy, 2018;Sun et al, 2019). The antimicrobial and antibiofilm activities of ZnO NPs against Gram-negative bacteria, Grampositive bacteria, and fungi was documented (Beyth et al, 2015;Gunalan, Sivaraj, & Rajendran, 2012;Jiang et al, 2018;Zvekić, Srdić, Karaman, & Matavulj, 2011), the antibacterial and antifungal activity of ZnO nanocomposites was also accentuated (Sikora et al, 2018;Yu et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

In-vitro evaluation of antibacterial and antibiofilm efficiency of radiation-modified polyurethane–ZnO nanocomposite to be used as a self-disinfecting catheter

Hosny

Farrag

Helmy

et al. 2020

Journal of Radiation Research and Applied Sciences

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In the era of antibiotic resistance, antimicrobial polymers represent state of the art innovation evolved to fight biofilm-associated infections. In the present study, novel self-disinfecting polyurethane (PU) catheter materials were developed. Gamma radiation-induced graft copolymerization was used to functionalize PU using acrylic acid-co-glycidyl methacrylate (AAc/GMA) binary comonomer. The grafted PU, PU-g-(AAc-co-GMA), was subsequently modified by covalent immobilization of cefepime and/or wet in-situ intermatrix synthesis of ZnO (NPs) to produce PU-g-(AAc-co-GMA)/cefepime, PU-g-(AA-co-GMA-cefepime/ZnO and PU-g-(AAc-co-GMA)/ZnO nanocomposites, respectively. Modified polymers were characterized by Fourier transform infrared spectroscopy (FTIR), energy dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), and scanning electron microscope (SEM). Finally, the antibacterial and antibiofilm characteristics were evaluated against five multidrug-resistant (MDR) clinical bacterial isolates; including Gram-positive and Gram-negative microorganisms. FTIR confirmed the successful grafting and subsequent immobilization of cefepime. Formation of ZnO was verified by EDX analysis, while XRD analysis revealed the crystalline nature of ZnO NPs with a size range of 43-62 nm. Moreover, SEM showed the morphology, particle size and distribution of ZnO NPs within the prepared nanocomposites. The modified PU catheter nancomposites with or without cefepime showed excellent antibacterial and anti-biofilm characteristics. The prepared polymeric biocides could be potential candidates in medical care to combat biofilm formation on biomaterials.

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Section: Introductionmentioning

confidence: 99%

In-vitro evaluation of antibacterial and antibiofilm efficiency of radiation-modified polyurethane–ZnO nanocomposite to be used as a self-disinfecting catheter

Hosny

Farrag

Helmy

et al. 2020

Journal of Radiation Research and Applied Sciences

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“…Incorporation of metals into the polymer matrix can improve its mechanical properties, retard erosion, and enhance biological effects [113,238,239]. For example, Mahmoud et al [240] developed mucoadhesive hydrogel composites based on acrylic acid, polyethylene glycol and zinc oxide nanoparticles for local buccal delivery of propranolol. It was shown that the introduction of ZnO nanoparticles improved the thermal stability of the composites, but ZnO reduced the mucoadhesion of the obtained systems in artificial saliva solution about 2-fold; at the same time, it was possible to achieve high mucoadhesion by increasing the acrylic acid in the system up to 90 mass %.…”

Section: Nanotechnology-based Systems To Improve Buccal Drug Deliverymentioning

confidence: 99%

Biopolymer Drug Delivery Systems for Oromucosal Application: Recent Trends in Pharmaceutical R&D

Dubashynskaya,

Petrova,

Skorik

2024

IJMS

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Oromucosal drug delivery, both local and transmucosal (buccal), is an effective alternative to traditional oral and parenteral dosage forms because it increases drug bioavailability and reduces systemic drug toxicity. The oral mucosa has a good blood supply, which ensures that drug molecules enter the systemic circulation directly, avoiding drug metabolism during the first passage through the liver. At the same time, the mucosa has a number of barriers, including mucus, epithelium, enzymes, and immunocompetent cells, that are designed to prevent the entry of foreign substances into the body, which also complicates the absorption of drugs. The development of oromucosal drug delivery systems based on mucoadhesive biopolymers and their derivatives (especially thiolated and catecholated derivatives) is a promising strategy for the pharmaceutical development of safe and effective dosage forms. Solid, semi-solid and liquid pharmaceutical formulations based on biopolymers have several advantageous properties, such as prolonged residence time on the mucosa due to high mucoadhesion, unidirectional and modified drug release capabilities, and enhanced drug permeability. Biopolymers are non-toxic, biocompatible, biodegradable and may possess intrinsic bioactivity. A rational approach to the design of oromucosal delivery systems requires an understanding of both the anatomy/physiology of the oral mucosa and the physicochemical and biopharmaceutical properties of the drug molecule/biopolymer, as presented in this review. This review summarizes the advances in the pharmaceutical development of mucoadhesive oromucosal dosage forms (e.g., patches, buccal tablets, and hydrogel systems), including nanotechnology-based biopolymer nanoparticle delivery systems (e.g., solid lipid particles, liposomes, biopolymer polyelectrolyte particles, hybrid nanoparticles, etc.).

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“…Polyethylene acrylate copolymer blends with sulfonates are attested to improve blood compatibility with the addition of platelets and with bacterial repellence [10]. It is interesting that acrylic composite with metal oxides are reported to their an effective mucoadhesive carrier for buccal drug delivery [11]. Also, they study their antimicrobial properties with pathogenic microorganisms namely Staphylococcus aureus, Bucillus subtilis, and Escherichia coli.…”

Section: Introductionmentioning

confidence: 99%

Design of Novel Poly(Propranolol) Acrylate and Methacrylate Polymers through Radical Polymerization for Antibacterial Activity and Metal Ion Absorption

Kumar,

Kamaraj,

Vivekanand

et al. 2024

International Journal of Polymer Science

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The monomer 1-(isopropylamino)-3-(1-naphthyloxy)-2-propanoacrylate (IANOPA) and monomer 1-(isopropylamino)-3-(1-naphthyloxy)-2-propanomethacrylate (IANOPMA) were synthesized by treating 1-(isopropylamino)-3-(1-naphthyloxy)-2-propanol with acryloylchloride/methacryloyl chloride. The above esterification reactions were carried out in the presence of triethylamine. By employing the free radical polymerization method, the synthesized monomers were converted into polymers by using an initiator 2, 2′-azobisisobutyronitrile in the presence of nitrogen environment at 70±2°C. The monomers and polymers were characterized by various techniques such as FT-IR, UV, 1H NMR, and 13C NMR spectroscopic analyses. Further, differential scanning calorimetry (DSC) was used to estimate the glass transition temperature (Tg). Gel permeation chromatography (GPC) was used to estimate the molecular weight of the polymers. In addition, monomer and polymer surfaces’ morphology was analyzed using SEM analysis. As a primary application, the effectiveness of synthesized monomers and polymers was explored as antibacterial agents against gram-positive bacteria (Staphylococcus aureus) and gram-negative bacteria (Pseudomonas aeruginosa) which were measured from their inhibitory zone diameters. Further, the synthesized polymers, poly-IANOPA and poly-IANOPMA, were utilized for the uptake ability study of heavy metal ions such as Zn2+, Cu2+, Ni2+, and Pb2+ present in water sources by equilibrium method.

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Development of (acrylic acid/ polyethylene glycol)-zinc oxide mucoadhesive nanocomposites for buccal administration of propranolol HCl

Cited by 24 publications

References 52 publications

In-vitro evaluation of antibacterial and antibiofilm efficiency of radiation-modified polyurethane–ZnO nanocomposite to be used as a self-disinfecting catheter

In-vitro evaluation of antibacterial and antibiofilm efficiency of radiation-modified polyurethane–ZnO nanocomposite to be used as a self-disinfecting catheter

Biopolymer Drug Delivery Systems for Oromucosal Application: Recent Trends in Pharmaceutical R&D

Design of Novel Poly(Propranolol) Acrylate and Methacrylate Polymers through Radical Polymerization for Antibacterial Activity and Metal Ion Absorption

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