2020
DOI: 10.1080/16878507.2020.1719328
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In-vitro evaluation of antibacterial and antibiofilm efficiency of radiation-modified polyurethane–ZnO nanocomposite to be used as a self-disinfecting catheter

Abstract: In the era of antibiotic resistance, antimicrobial polymers represent state of the art innovation evolved to fight biofilm-associated infections. In the present study, novel self-disinfecting polyurethane (PU) catheter materials were developed. Gamma radiation-induced graft copolymerization was used to functionalize PU using acrylic acid-co-glycidyl methacrylate (AAc/GMA) binary comonomer. The grafted PU, PU-g-(AAc-co-GMA), was subsequently modified by covalent immobilization of cefepime and/or wet in-situ int… Show more

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Cited by 9 publications
(9 citation statements)
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“…The presence of more hydrophilic groups on the PUF-PVA gel carrier favors biofilm attachment and growth. This conclusion is in good agreement with other researchers [54,56].…”
Section: Enhanced Biofilm Attachment Of Puf-pva Gel Compared To Puf I...supporting
confidence: 94%
“…The presence of more hydrophilic groups on the PUF-PVA gel carrier favors biofilm attachment and growth. This conclusion is in good agreement with other researchers [54,56].…”
Section: Enhanced Biofilm Attachment Of Puf-pva Gel Compared To Puf I...supporting
confidence: 94%
“…64 Researchers have attempted to incorporate NPs such as Ag, copper (Cu), ZnO, and TiO 2 into PU medical consumables (eg catheters) to improve the materials' antibacterial and anti-aging properties. [84][85][86] In dentistry, PUs are used mainly as thermosetting sealers and filling materials. The inclusion of NPs such as SiO 2 and nHA in PUs can improve antibacterial effects and adhesion to dental tissues.…”
Section: Other Applicationsmentioning
confidence: 99%
“…The treatment was started by RIGC of a mixture of AA and GMA onto the PU catheter, followed by in-situ formation of ZnONPs. The obtained nanocomposite catheter showed excellent antibacterial and anti-biofilm formation characteristics [ 77 ]. The latest progress in development of antimicrobial surfaces with metal and metal oxides NPs coatings have been recently reviewed [ 78 ].…”
Section: Synergizing Of Antimicrobial Properties By Metallic Nanoparticlesmentioning
confidence: 99%