Development of Advanced Drug Delivery Systems with Bicalutamide Based on Mesoporous Silica Particles

Popova, Teodora; Tzankov, Borislav; Voycheva, Christina; Yoncheva, Krassimira; Lambov, Nikolay

doi:10.7546/crabs.2019.12.08

Cited by 2 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The MSNs comprise an open system of pores that allows the loading of drugs. These drugs can quickly diffuse, depending on the solvent and the type of drug [2,3,5,6]. One of the advantages of mesoporous silica nanoparticles is their high loading capacity, based on the significant pore volume.…”

Section: Surface Functionalisation Drug Loading and Drug Releasementioning

confidence: 99%

“…This simple method has continued to be the most popular way to load drugs into porous silica particles [2,3,5]. The use of a non-solvent most often allows the loading of the drug substance [6]. In parallel with the preparation of mesoporous silica particles, the bioactive substance could be successfully loaded.…”

Section: Surface Functionalisation Drug Loading and Drug Releasementioning

confidence: 99%

“…These systems can also solve the problem of poor aqueous solubility of drugs by loading them into the mesoporous silica nanoparticle pores. Limited internal space improves drug dissolution, probably due to a decrease in its degree of crystallinity [5,6]. This review was aimed at providing methods for synthesis of various types of MSNs used as drug delivery systems, loading of bioactive substances, functional group grafting, and drug release.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Mesoporous silica nanoparticles: Synthesis, functionalization, drug loading and release - A review

Galabova¹

2022

Trop. J. Pharm Res

View full text Add to dashboard Cite

A brief survey on the synthesis of several types of mesoporous silica nanoparticles and their uses as drug delivery nanocarriers is presented in this study. Mesoporous silica nanoparticles (MSNs) have a small pore size, resulting in a large surface area and porosity. These characteristics are easily adjustable, conferring on MSNs advantages over other nanoparticles for use in medicine and pharmacy. Previous and latest trends in the technology of this type of nanoparticles, and the possibilities for their application in drug loading are considered, as well as methods for increasing drug loading capacity, functionalization and release of bioactive substances. It has been found that the method used for the synthesis of some types of MSNs results in better drug loading. The functionalization of nanoparticles not only allows for more successful loading of bioactive substances in its pores, it also successfully controls drug release. Moreover, these versatile nanoparticles enhance the solubility of poorly-soluble drugs, thereby overcoming one of the biggest problems in the absorption of these drugs.

show abstract

Section: Surface Functionalisation Drug Loading and Drug Releasementioning

confidence: 99%

Section: Surface Functionalisation Drug Loading and Drug Releasementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Mesoporous silica nanoparticles: Synthesis, functionalization, drug loading and release - A review

Galabova¹

2022

Trop. J. Pharm Res

View full text Add to dashboard Cite

show abstract

Functionalization and Polymer Coating – Strategies to improve Drug Delivery from Mesoporous Silica Nanoparticles

Kovachev

2022

RJPT

View full text Add to dashboard Cite

The mesoporous silica particles (MSNs) have been investigated as potential drug delivery carriers. They have an extensive surface area and pore volume. Many silanol groups are located along the particles' entire outer and inner surfaces. They make it possible to create bonds or interactions between the drug molecules and the carrier. Still, They are also an extremely suitable basis for further functionalization of the particle and pore surface. This review examines how the functionalization of MSNs, on the one hand, allows more successful loading of active substances into their pores and, on the other hand, successfully controls their release. Upon loading sparingly soluble drugs, an improvement in their solubility was found, most likely by amorphization, obtained after crystallization of the problem substance in the delicate pores of these specific carriers. The synthesis of some types of silicate carriers is a method for improving the loading of the particles with active substances is confirmed.

show abstract

Development of Advanced Drug Delivery Systems with Bicalutamide Based on Mesoporous Silica Particles

Cited by 2 publications

References 0 publications

Mesoporous silica nanoparticles: Synthesis, functionalization, drug loading and release - A review

Mesoporous silica nanoparticles: Synthesis, functionalization, drug loading and release - A review

Functionalization and Polymer Coating – Strategies to improve Drug Delivery from Mesoporous Silica Nanoparticles

Contact Info

Product

Resources

About