Mesoporous silica nanoparticles: Synthesis, functionalization, drug loading and release - A review

Abstract


 
 
 
 A brief survey on the synthesis of several types of mesoporous silica nanoparticles and their uses as drug delivery nanocarriers is presented in this study. Mesoporous silica nanoparticles (MSNs) have a small pore size, resulting in a large surface area and porosity. These characteristics are easily adjustable, conferring on MSNs advantages over other nanoparticles for use in medicine and pharmacy. Previous and latest trends in the technology of this type of nanoparticles, and the possibilities for their application in drug loading are considered, as well as methods for increasing drug loading capacity, functionalization and release of bioactive substances. It has been found that the method used for the synthesis of some types of MSNs results in better drug loading. The functionalization of nanoparticles not only allows for more successful loading of bioactive substances in its pores, it also successfully controls drug release. Moreover, these versatile nanoparticles enhance the solubility of poorly-soluble drugs, thereby overcoming one of the biggest problems in the absorption of these drugs.
 
 
 

Exploiting recent trends for the synthesis and surface functionalization of mesoporous silica nanoparticles towards biomedical applications

“… The powdered solid SiO 2 got dispersed during heat treatment, and the formation of mesophase assembly occurs after the removal of heat. ( Galabova, 2021 ). Morphology of MSNs Formulation parameters, such as temperature, pH, and reagent concentrations, affect the morphology and size of the particles.…”

Photosensitizer‐Mesoporous Silica Nanoparticles Combination for Enhanced Photodynamic Therapy†

“…For that reason, MSNs are considered more versatile than nonporous silica NPs. Besides, MSNs could be synthesized with different shapes: sphere-like, yolk-shell, hollow and peanut-like structures, being sphere nanostructures preferred for their use as carriers (60)(61)(62)(63). Their potential use as a drug delivery system was firstly proposed by Vallet-Reg ı in 2001 (64).…”

Review on Theoretical Models of Void Evolution in Crystalline Particles

“…Determined by high specific area and surface-tovolume ratio, low density and encapsulate option, hollow structures exhibit higher performance than their solid counterparts with the same composition and size that tremendously extends their application in the fields of plasmonics [3][4][5], catalysis [6][7][8][9][10][11], energy storing [12][13][14][15] and medicine [16][17][18]. For instance, hollow metal nanoparticles have significantly higher plasmonic properties than their solid counterparts due to so-called mechanism of plasmon hybridization.…”