The application of communication information in 21st-century learning has become popular to promote various students’ skills. This study investigates the impact of the STEM-integrated smartphone-based physics E-module (STEM-Smart Physics E-Module) to promote students’ conceptual understanding and Communication, Collaboration, Critical Thinking, and Creativity (4C) skills. This research method can be classified into a quasi-experimental method. The research design was based on a post-test-only control group design. Instruments for collecting data consisted of two types: written tests to assess conceptual understanding and performance assessment sheets to assess the three components of students’ 4C skills. The results show that the application of STEM-Smart Physics E-Module positively impacts students’ conceptual understanding and three components of the 4C skills, namely creative thinking, critical thinking, and communication.